A phase II, non-comparative randomised trial of two treatments involving liposomal amphotericin B and miltefosine for post-kala-azar dermal leishmaniasis in India and Bangladesh.

Autor: Shyam Sundar, Krishna Pandey, Dinesh Mondal, Major Madhukar, Roshan Kamal Topno, Ashish Kumar, Vinod Kumar, Deepak Kumar Verma, Jaya Chakravarty, Rahul Chaubey, Poonam Kumari, Md Utba Rashid, Shomik Maruf, Prakash Ghosh, Sheeraz Raja, Joelle Rode, Margriet den Boer, Pradeep Das, Jorge Alvar, Suman Rijal, Fabiana Alves

Publikováno v: PLoS Neglected Tropical Diseases, Vol 18, Iss 6, p e0012242 (2024)

BackgroundIn Southeast Asia, treatment is recommended for all patients with post-kala-azar dermal leishmaniasis (PKDL). Adherence to the first-line regimen, twelve weeks of miltefosine (MF), is low and ocular toxicity has been observed with this expo

Externí odkaz: https://doaj.org/article/b7e6f04169cb474393f3f95d3365f3ec

A phase II multicenter randomized study to evaluate the safety and efficacy of combining thermotherapy and a short course of miltefosine for the treatment of uncomplicated cutaneous leishmaniasis in the New World.

Autor: Liliana López, Braulio Valencia, Fiorela Alvarez, Ana Pilar Ramos, Alejandro Llanos-Cuentas, Juan Echevarria, Iván Vélez, Marina Boni, Joelle Rode, Juliana Quintero, Alejandra Jiménez, Yulied Tabares, Claudia Méndez, Byron Arana

Publikováno v: PLoS Neglected Tropical Diseases, Vol 16, Iss 3, p e0010238 (2022)

BackgroundSystemic pentavalent antimonials, mainly meglumine antimoniate, continue to be the first-choice drugs for treatment of cutaneous leishmaniasis (CL) despite their toxicity, difficulty of administration and high cost. In the search for therap

Externí odkaz: https://doaj.org/article/7d38ed91d4fd43ceaad0a96cea2a20d1

Harmonized clinical trial methodologies for localized cutaneous leishmaniasis and potential for extensive network with capacities for clinical evaluation.

Autor: Piero Olliaro, Max Grogl, Marina Boni, Edgar M Carvalho, Houda Chebli, Mamoudou Cisse, Ermias Diro, Gláucia Fernandes Cota, Astrid C Erber, Endalamaw Gadisa, Farhad Handjani, Ali Khamesipour, Alejandro Llanos-Cuentas, Liliana López Carvajal, Lise Grout, Badre Eddine Lmimouni, Mourad Mokni, Mohammad Sami Nahzat, Afif Ben Salah, Yusuf Ozbel, Juan Miguel Pascale, Nidia Rizzo Molina, Joelle Rode, Gustavo Romero, José Antonio Ruiz-Postigo, Nancy Gore Saravia, Jaime Soto, Soner Uzun, Vahid Mashayekhi, Ivan Dario Vélez, Florian Vogt, Olga Zerpa, Byron Arana

Publikováno v: PLoS Neglected Tropical Diseases, Vol 12, Iss 1, p e0006141 (2018)

Progress with the treatment of cutaneous leishmaniasis (CL) has been hampered by inconsistent methodologies used to assess treatment effects. A sizable number of trials conducted over the years has generated only weak evidence backing current treatme

Externí odkaz: https://doaj.org/article/ef3ff102cf1848f5a91bb95d75b6865e

In Vitro Susceptibility to Miltefosine of

Autor: Erica Valadares de Castro Levatti, Silvia R. B. Uliana, Mariana Côrtes Boité, Dorcas Lamounier, Carlos Henrique Nery Costa, Joelle Rode, Caroline R. Espada, Jorge Alvar, Elisa Cupolillo

Publikováno v: Microorganisms
Microorganisms, Vol 9, Iss 1228, p 1228 (2021)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Volume 9
Issue 6

Treatment of visceral leishmaniasis in Brazil still relies on meglumine antimoniate, with less than ideal efficacy and safety, making new therapeutic tools an urgent need. The oral drug miltefosine was assayed in a phase II clinical trial in Brazil w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e72bdc746f00dd05151f0ad62e9444f1
https://pubmed.ncbi.nlm.nih.gov/34198947

Harmonized clinical trial methodologies for localized cutaneous leishmaniasis and potential for extensive network with capacities for clinical evaluation

Autor: Jaime Soto, Joelle Rode, Alejandro Llanos-Cuentas, Juan Miguel Pascale, Afif Ben Salah, Astrid C. Erber, Mourad Mokni, Liliana López Carvajal, Lise Grout, Byron Arana, Nidia Rizzo Molina, Vahid Mashayekhi, Iván D. Vélez, Max Grogl, Ermias Diro, Olga Zerpa, Marina Boni, Endalamaw Gadisa, Nancy G. Saravia, Mamoudou Cisse, Ali Khamesipour, Florian Vogt, Soner Uzun, Edgar M. Carvalho, Houda Chebli, Mohammad Sami Nahzat, Badre Eddine Lmimouni, Piero Olliaro, Farhad Handjani, Gláucia Fernandes Cota, Yusuf Özbel, José Antonio Ruiz-Postigo, Gustavo Adolfo Sierra Romero

Publikováno v: Repositorio UdeA
Universidad de Antioquia
instacron:Universidad de Antioquia
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Public Library of Science, 2018, 12 (1), pp.e0006141. ⟨10.1371/journal.pntd.0006141⟩
PLoS Neglected Tropical Diseases, Vol 12, Iss 1, p e0006141 (2018)

WOS: 000424022700022
PubMed ID: 29329311
Introduction Progress with the treatment of cutaneous leishmaniasis (CL) has been hampered by inconsistent methodologies used to assess treatment effects. A sizable number of trials conducted over th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1cc1157239e4c9387b888147fac036d
https://doi.org/10.1371/journal.pntd.0006141