Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Joelle, Le"'
Autor:
Alison E. John, Rebecca H. Graves, K. Tao Pun, Giovanni Vitulli, Ellen J. Forty, Paul F. Mercer, Josie L. Morrell, John W. Barrett, Rebecca F. Rogers, Maryam Hafeji, Lloyd I. Bibby, Elaine Gower, Valerie S. Morrison, Yim Man, James A. Roper, Jeni C. Luckett, Lee A. Borthwick, Ben S. Barksby, Rachel A. Burgoyne, Rory Barnes, Joelle Le, David J. Flint, Susan Pyne, Anthony Habgood, Louise A. Organ, Chitra Joseph, Rochelle C. Edwards-Pritchard, Toby M. Maher, Andrew J. Fisher, Natasja Stæhr Gudmann, Diana J. Leeming, Rachel C. Chambers, Pauline T. Lukey, Richard P. Marshall, Simon J. F. Macdonald, R. Gisli Jenkins, Robert J. Slack
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The αvβ6 integrin is key in activating the pro-fibrotic cytokine TGFβ in idiopathic pulmonary fibrosis. Here, the authors show an inhaled small molecule αvβ6 inhibitor GSK3008348 induces prolonged inhibition of TGFβ signaling pathways in human
Externí odkaz:
https://doaj.org/article/0b6e5916f4cb4d2e9b4186f07f1b86ee
Autor:
Marie-Christine Grach, Sonia Cauchin, Sylvie Gehanne, Rachel Bignon, Nathalie Roux, Virith Sep Hieng, Maud Gicquère, Christine Le Gal, Virginie Prevost, Claire Delorme, Carole Van Delook, Joelle Le Garrec, Maryline Feuillet, Cécile Bisson, Franck Lecaer, Marie-Claude Ropartz, Anne-Laure Millet, Isabelle Lepleux, Bénédicte Clarisse, Cyril Guillaumé, Aline Le Chevalier
Publikováno v:
Douleurs : Évaluation - Diagnostic - Traitement. 22:117-127
Resume Objectif Ce travail presente la strategie utilisee pour construire un programme d’education therapeutique des patients (ETP) sur la douleur liee au cancer, sa mise en œuvre en region et l’identification des freins et des leviers concernan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab2b49cea8585b95996e984987d5bceb
https://doi.org/10.1016/j.douler.2021.04.004
https://doi.org/10.1016/j.douler.2021.04.004
Autor:
Natasja Stæhr Gudmann, Richard P. Marshall, Jeni Luckett, Rebecca F. Rogers, Robert J. Slack, Simon J. F. Macdonald, Diana Julie Leeming, Rachel C. Chambers, Joelle Le, Pauline T. Lukey, Anthony Habgood, Paul F. Mercer, Rachel A. Burgoyne, Ben S. Barksby, Lloyd I. Bibby, Yim Man, Maryam Hafeji, Andrew J. Fisher, David J. Flint, Toby M. Maher, Louise Organ, Susan Pyne, Lee A. Borthwick, James A. Roper, Valerie S. Morrison, Alison E. John, Giovanni Vitulli, Rebecca H. Graves, Rochelle C. Edwards-Pritchard, R. Gisli Jenkins, John Barrett, Josie Morrell, K. Tao Pun, Elaine Gower, Rory Barnes, Ellen J. Forty, Chitra Joseph
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
The αvβ6 integrin plays a key role in the activation of transforming growth factor-β (TGFβ), a pro-fibrotic mediator that is pivotal to the development of idiopathic pulmonary fibrosis (IPF). We identified a selective small molecule αvβ6 RGD-mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5b4959cf67302e9783a88dddd530b0b
https://doaj.org/article/0b6e5916f4cb4d2e9b4186f07f1b86ee
https://doaj.org/article/0b6e5916f4cb4d2e9b4186f07f1b86ee
Autor:
Vincent Mikol, Dominique Françon, Raphael Gorski, Pascal Paul, Sandrine Roche, Margerie Clement, El-Bdaoui Haddad, Clara Ponsolles, Laurence Rocheteau-Beaujouan, Bruno Biton, Marie-Dominique Bock, Cécile Orsini, Marion Classe, Maud Leonetti, Jean-Claude Guillemot, Anne Remaury, Joelle Le-Guern, Angela Rouyar, Michel Didier, Valerie Fourgous
Publikováno v:
Allergy
Background Chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) is a chronic inflammatory disease often accompanied by impairment of sense of smell. This symptom has been somewhat overlooked, and its relationship to inflammatory cytokines, tissue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b44c85a3b40439c734bd4e9729caa6b0
https://doi.org/10.1111/all.13559
https://doi.org/10.1111/all.13559
Autor:
Richard P. Marshall, John Martin Pritchard, Josie Morrell, Simon J. F. Macdonald, Seble Lemma, John F. Barrett, Paula Saklatvala, Robert J. Slack, Panayiotis A. Procopiou, Joelle Le, Tim N. Barrett, Ashley Paul Hancock, James E. Rowedder, Matthew H. J. Crawford, Anderson Niall Andrew, Giovanni Vitulli, Colin J. Suckling, Brendan J. Fallon, Steven L. Sollis, Lee R. Thorp
Publikováno v:
Journal of Medicinal Chemistry. 61:8417-8443
A series of 3-aryl(pyrrolidin-1-yl)butanoic acids were synthesized using a diastereoselective route, via a rhodium catalyzed asymmetric 1,4-addition of arylboronic acids in the presence of (R)-BINAP to a crotonate ester to provide the (S) absolute co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5661106b41cca877b5043e391b8cef81
https://doi.org/10.1021/acs.jmedchem.8b00959
https://doi.org/10.1021/acs.jmedchem.8b00959
Autor:
Joelle Le, Pauline T. Lukey, Steven B. Ludbrook, Simon J. F. Macdonald, Robert J. Slack, Richard J. D. Hatley
Publikováno v:
Angewandte Chemie. 130:3354-3379
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4481f379fb341c80abcbc386696f5bd
https://doi.org/10.1002/ange.201707948
https://doi.org/10.1002/ange.201707948
Autor:
Young Do, Lisa A. Orband-Miller, Anthony Shillings, Joelle Le, Caterina Musetti, Gordon Saxty, Beth Pietrak, Simon Teanby Hodgson, Petrov Kimberly, Daniel J. Price, Stephen A. Thomson, Eugene L. Stewart, Christie Schulte, Ashley Paul Hancock, Terrence L. Smalley, Michael R. Jeune, H. Fritz Kramer, Chuck Poole, Heather Hobbs, Kirsten M. Kahler, J. Darren Stuart, Paul N. Mortenson, Robert T. Nolte, Jason A. Holt, David N. Deaton, Don O. Somers, Elsie Diaz, Jeffrey Guss, Robert T. Gampe, Peckham Gregory
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 47:128113
Through an internal virtual screen at GlaxoSmithKline a distinct class of 2-phenylimidazo[1,2-a]pyridine-6-carboxamide H-PGDS inhibitors were discovered. Careful evaluation of crystal structures and SAR led to a novel, potent, and orally active imida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7e5ec2ff7577c529db47e5be2c91881
https://doi.org/10.1016/j.bmcl.2021.128113
https://doi.org/10.1016/j.bmcl.2021.128113
Autor:
Aurelie C. Champigny, Daniel Thomas, Ian Robert Baldwin, Simon Gaines, Paul Faulder, Benjamin D. Bax, Laura M. Inglesby, Z.A. Henley, Yoshiaki Washio, Joelle Le
Publikováno v:
ACS Medicinal Chemistry Letters. 8:1093-1098
Selective inhibitors of phosphoinositide 3-kinase delta are of interest for the treatment of inflammatory diseases. Initial optimization of a 3-substituted indazole hit compound targeting the kinase PIM1 focused on improving selectivity over GSK3β t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27f5519d38d282f0bd73dd26004a6f3a
https://doi.org/10.1021/acsmedchemlett.7b00296
https://doi.org/10.1021/acsmedchemlett.7b00296
Autor:
Virith Sep Hieng, Joelle Le Garrec, Marie-Claude Ropartz, Natacha Heutte, C. Delorme, Nathalie Roux, Alexandra Leconte, Carole Van Delook, Cécile Bisson, Cyril Guillaumé, Franck Lecaer, Maryline Feuillet, Rachel Bignon, Aline Le Chevalier, Maud Gicquère, Anne-Laure Millet, Virginie Prevost, Bénédicte Clarisse, Marie-Christine Grach, Sonia Cauchin, Isabelle Lepleux, Sylvie Gehanne, Christine Le Gal
Publikováno v:
Journal of Cancer Education
Journal of Cancer Education, Springer Verlag, 2018, 33 (6), pp.1355-1361. ⟨10.1007/s13187-017-1258-8⟩
Journal of Cancer Education, Springer Verlag, 2018, 33 (6), pp.1355-1361. ⟨10.1007/s13187-017-1258-8⟩
International audience; In the field of cancer pain, therapeutic patient education (TPE) allows patients to develop skills to better manage their pain. In the Lower Normandy region of France, the management of pain is based on networking, thus allowi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::483f649c8a5268c5cd1073e9afb31821
https://doi.org/10.1007/s13187-017-1258-8
https://doi.org/10.1007/s13187-017-1258-8
Autor:
Joelle Le, Sharon Butler, James E. Rowedder, Stephen M. Harrison, John Martin Pritchard, Anderson Niall Andrew, Claire E. Smith, Rosemary Maghames, Simon J. F. Macdonald, Aleix Pastor-Garcia, Sebastien Andre Campos, Giovanni Vitulli, Jack Thomas, Royston C. B. Copley, Ian B. Duncan
Publikováno v:
Journal of medicinal chemistry. 62(19)
The heterodimeric transmembrane αv integrin receptors have recently emerged as potential targets for the treatment of idiopathic pulmonary fibrosis. Herein, we describe how subtle modifications of the central aromatic ring of a series of phenylbutyr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26214873182de29f352e72fc31366e1a
https://pubmed.ncbi.nlm.nih.gov/31497959
https://pubmed.ncbi.nlm.nih.gov/31497959