Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Joel Z Nordin"'
Autor:
Antje M. Zickler, Xiuming Liang, Dhanu Gupta, Doste R. Mamand, Mariacristina De Luca, Giulia Corso, Lorenzo Errichelli, Justin Hean, Titash Sen, Omnia M. Elsharkasy, Noriyasu Kamei, Zheyu Niu, Guannan Zhou, Houze Zhou, Samantha Roudi, Oscar P. B. Wiklander, André Görgens, Joel Z. Nordin, Virginia Castilla‐Llorente, Samir EL Andaloussi
Publikováno v:
Advanced Science, Vol 11, Iss 42, Pp n/a-n/a (2024)
Abstract Messenger RNA (mRNA) has emerged as an attractive therapeutic molecule for a plethora of clinical applications. For in vivo functionality, mRNA therapeutics require encapsulation into effective, stable, and safe delivery systems to protect t
Externí odkaz:
https://doaj.org/article/57285ee9b4914259979d9194d408bdbc
Autor:
Helena Sork, Joel Z Nordin, Janne J Turunen, Oscar PB Wiklander, Burcu Bestas, Eman M Zaghloul, Helerin Margus, Kärt Padari, Adil D Duru, Giulia Corso, Jeremy Bost, Pieter Vader, Margus Pooga, CI Edvard Smith, Matthew JA Wood, Raymond M Schiffelers, Mattias Hällbrink, Samir EL Andaloussi
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
The advantages of lipid-based transfection reagents have permitted their widespread use in molecular biology and gene therapy. This study outlines the effect of cryo-manipulation of a cationic lipid-based formulation, Lipofectamine 2000, which, after
Externí odkaz:
https://doaj.org/article/48a6da84132a4f1db17f5fc1b93f1a61
Autor:
Sofia Stenler, Oscar PB Wiklander, Maria Badal-Tejedor, Janne Turunen, Joel Z Nordin, David Hallengärd, Britta Wahren, Samir EL Andaloussi, Mark W Rutland, CI Edvard Smith, Karin E Lundin, Pontus Blomberg
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 3, Iss C (2014)
The minicircle (MC), composed of eukaryotic sequences only, is an interesting approach to increase the safety and efficiency of plasmid-based vectors for gene therapy. In this paper, we investigate micro-MC (miMC) vectors encoding small regulatory RN
Externí odkaz:
https://doaj.org/article/f6a327b6051943f3936632a5f1af2970
Autor:
Suzan M Hammond, Graham McClorey, Joel Z Nordin, Caroline Godfrey, Sofia Stenler, Kim A Lennox, CI Edvard Smith, Ashley M Jacobi, Miguel A Varela, Yi Lee, Mark A Behlke, Matthew J A Wood, Samir E L Andaloussi
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 3, Iss C (2014)
Splice switching oligonucleotides (SSOs) induce alternative splicing of pre-mRNA and typically employ chemical modifications to increase nuclease resistance and binding affinity to target pre-mRNA. Here we describe a new SSO non-base modifier (a naph
Externí odkaz:
https://doaj.org/article/610e0a409d3146f7beb11ae6ad8495ab
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 8, Pp n/a-n/a (2024)
Abstract Background and main body Pharmacokinetics (PK) and pharmacodynamics (PD) are central concepts to guide the dosage and administration of drug therapies and are essential to consider for both healthcare professionals and researchers in therape
Externí odkaz:
https://doaj.org/article/56c04af6edb64a13b86f110e4d4e7302
Autor:
Doste R. Mamand, Safa Bazaz, Dara K. Mohammad, Xiuming Liang, Svetlana Pavlova, Carsten Mim, Susanne Gabrielsson, Joel Z. Nordin, Oscar P. B. Wiklander, Manuchehr Abedi‐Valugerdi, Samir EL‐Andaloussi
Publikováno v:
Journal of Extracellular Vesicles, Vol 13, Iss 7, Pp n/a-n/a (2024)
Abstract Haematopoiesis dysregulation with the presence of immature myeloid and erythroid immunosuppressive cells are key characteristics of the immune escape phase of tumour development. Here, the role of in vitro generated B16F10 tumour cell‐deri
Externí odkaz:
https://doaj.org/article/1c7ed4f843a74655872ea6309bf7b745
Autor:
Wenyi Zheng, Julia Rädler, Helena Sork, Zheyu Niu, Samantha Roudi, Jeremy P. Bost, André Görgens, Ying Zhao, Doste R. Mamand, Xiuming Liang, Oscar P. B. Wiklander, Taavi Lehto, Dhanu Gupta, Joel Z. Nordin, Samir EL Andaloussi
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Extracellular vesicles (EVs) are gaining ground as next-generation drug delivery modalities. Genetic fusion of the protein of interest to a scaffold protein with high EV-sorting ability represents a robust cargo loading strategy. To address
Externí odkaz:
https://doaj.org/article/622f51f2cad347f4917ee57145e74779
Autor:
Joel Z. Nordin
Publikováno v:
Journal of Extracellular Vesicles, Vol 11, Iss 10, Pp n/a-n/a (2022)
Externí odkaz:
https://doaj.org/article/9c3b1aaa07904de7a747fed1b80cb49b
Autor:
Xiuming Liang, Zheyu Niu, Valentina Galli, Nathalie Howe, Ying Zhao, Oscar P. B. Wiklander, Wenyi Zheng, Rim Jawad Wiklander, Giulia Corso, Christopher Davies, Justin Hean, Eleni Kyriakopoulou, Doste R. Mamand, Risul Amin, Joel Z. Nordin, Dhanu Gupta, Samir EL Andaloussi
Publikováno v:
Journal of Extracellular Vesicles, Vol 11, Iss 7, Pp n/a-n/a (2022)
Abstract Extracellular vesicles (EVs) have shown promise as potential therapeutics for the treatment of various diseases. However, their rapid clearance after administration could be a limitation in certain therapeutic settings. To solve this, an eng
Externí odkaz:
https://doaj.org/article/9620878d96184d60a46da34441e162df
Autor:
William J. Valentine, Sherif A. Mostafa, Suzumi M. Tokuoka, Fumie Hamano, Natsuko F. Inagaki, Joel Z. Nordin, Norio Motohashi, Yoshihiro Kita, Yoshitsugu Aoki, Takao Shimizu, Hideo Shindou
Publikováno v:
Frontiers in Physiology, Vol 12 (2022)
In Duchenne muscular dystrophy (DMD), lack of dystrophin increases the permeability of myofiber plasma membranes to ions and larger macromolecules, disrupting calcium signaling and leading to progressive muscle wasting. Although the biological origin
Externí odkaz:
https://doaj.org/article/dffd91e077b74473be10610053a34c06