Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Joel Unowsky"'
Autor:
Tina Kauss, A. Waseem Malick, Nicholas G. White, Karen Gaudin, Joel Unowsky, Melba Gomes, Boubakar Ba, Amélie Désiré, Thida Phoeung, Charan R. Behl, Marie-Hélène Langlois, Indravadan H. Patel
Publikováno v:
Antimicrobial Agents and Chemotherapy. 62(12)
Neonatal sepsis is a major cause of infant mortality in developing countries because of delayed injectable treatment, making it urgent to develop noninjectable formulations that can reduce treatment delays in resource-limited settings. Ceftriaxone, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09b4722c5f106cd82f9d786f15b7248d
http://ora.ox.ac.uk/objects/uuid:
http://ora.ox.ac.uk/objects/uuid:
Publikováno v:
Clinical Therapeutics. 21:103-117
Community-acquired pneumonia remains a significant health concern despite the availability of effective antibiotics. This randomized, double-masked, double-dummy, multicenter comparative trial was undertaken to compare the efficacy and safety of spar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2df6c2785333782e300611d3566d6580
https://doi.org/10.1016/s0149-2918(00)88271-5
https://doi.org/10.1016/s0149-2918(00)88271-5
Publikováno v:
Clinical therapeutics. 21(6)
The optimal antibiotic therapy for patients with acute bacterial exacerbations of chronic bronchitis (ABECB) who have failed to respond to previous oral antimicrobial therapy is not known; however, newer macrolide and fluoroquinolone antibiotics may
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea75b58b5e7c35d4c3a981950ecd34fa
https://pubmed.ncbi.nlm.nih.gov/10440620
https://pubmed.ncbi.nlm.nih.gov/10440620
Autor:
Joel Unowsky, Alfred John Corraz, Scott L. Dax, Rossman Pamela Loreen, N H Georgopapadakou, David L. Pruess, Rudolf L. Then, Norma K. Dunlap, Dennis D. Keith, Chung Chen Wei
Publikováno v:
Journal of medicinal chemistry. 35(10)
Two new series of dual-action antibacterial agents were synthesized in which penems and carbapenems were linked at the 2'-position to quinolones through either an ester or a carbamate moiety. Potent, broad-spectrum antibacterial activity was observed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a8b936346ea2f91bc48d5bfbb80415e
https://pubmed.ncbi.nlm.nih.gov/1588561
https://pubmed.ncbi.nlm.nih.gov/1588561
Publikováno v:
Chemotherapy. 34:272-276
The rat enteral and rabbit rectal models were utilized to study the effect of Capmul (medium chain glycerides) on the absorption of a selection of beta-lactam and aminoglycoside antibiotics. All tested non-orally available beta-lactam antibiotics (ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a648e1eb2982a26eec1f01a7c2708b9a
https://doi.org/10.1159/000238580
https://doi.org/10.1159/000238580
Autor:
Joel Unowsky, Chan Ka-Kong, G. Beskid, V. Fallat, Dennis D. Keith, Roy Cleeland, E. R. Lipschitz, D. H. Mcgarry
Publikováno v:
Antimicrobial Agents and Chemotherapy. 33:1072-1077
The in vitro activity of the dual-action antibacterial agent Ro 23-9424 was compared with those of cefotaxime, ceftazidime, ciprofloxacin, fleroxacin, imipenem, and amikacin against 358 aerobes and anaerobes. The MIC ranges, MICs for 50 and 90% of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::697f6c62e536aee5f0703347b7299589
https://doi.org/10.1128/aac.33.7.1072
https://doi.org/10.1128/aac.33.7.1072
Autor:
Joel Unowsky, Donald C. Hoppe
Publikováno v:
The Journal of Antibiotics. 31:662-666
Conventional strain and media improvement techniques were of limited success in increasing yields of the antibiotic aurodox (X-5108) above 0.5 g/liter. Higher yields were obtained by reversion of a zero producer followed by the selection of mutants r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d5032b7bde53483ffe67f38b1a04284
https://doi.org/10.7164/antibiotics.31.662
https://doi.org/10.7164/antibiotics.31.662
Publikováno v:
Infection and Immunity. 57:48-54
The effect of recombinant human interleukin-1 alpha (IL-1) on the resistance of normal and bone marrow-suppressed mice against bacterial infection was evaluated. IL-1 induced neutrophilia and enhanced the resistance of normal mice against acute, syst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5950e58c97697b76d98894cc9eae37e
https://doi.org/10.1128/iai.57.1.48-54.1989
https://doi.org/10.1128/iai.57.1.48-54.1989
Autor:
P.P. Hung, Walter H. Traub, N. Drees, W F DeLorenzo, Gerd Gross, Eiichi Furusawa, F.J. Gregory, Erwin Schöpf, D. Henzel, M. Vulpillat, Donald P. Levine, J. Mohler, Shinobu Fumsawa, Hans Ikenberg, Gerald P. Bodey, S.J. McCloud, Jennifer F Hoy, P. De Grandi, K. P. Fu, Dah Hsi Ho, Helga Fellner, Joel Unowsky, Gerhard Lebek, J.-F. Bauen, P. Vicart, A. Roussaki, M.E. Grace, Helen C. Alderman, Pranatharth H. Chandrasekar, Richard Egger, Alain Meulemans, Swante Allgulander, Kenneth V. I. Rolston, Maria Elena Alvarez, Tom Bergan
Publikováno v:
Chemotherapy. 32:I-VIII
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f303bce3348f5940cdc0410d573aa4e
https://doi.org/10.1159/000238454
https://doi.org/10.1159/000238454
Publikováno v:
Chemotherapy. 35:338-344
Ceftriaxone and cefotaxime are third-generation cephalosporins with similar in vitro potencies and spectra. However, previous studies have shown that ceftriaxone had superior in vivo activity (mouse PD50 values greater than or equal to 2-fold lower)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a0136484dcd5903c4f1c8be776463d2
https://doi.org/10.1159/000238692
https://doi.org/10.1159/000238692