Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Joel T. Welch"'
Publikováno v:
AAPS Open, Vol 10, Iss 1, Pp 1-11 (2024)
Abstract Structured product quality data offer tremendous promise to revolutionize the submission of drug applications. However, the quality attributes for biological products do not have a systematic naming taxonomy, and consequently this limit pose
Externí odkaz:
https://doaj.org/article/72e2a975380d40729bd55916752a1c53
Autor:
Jennifer L. Mantle, Jayan Rammohan, Eugenia F. Romantseva, Joel T. Welch, Leah R. Kauffman, Jim McCarthy, John Schiel, Jeffrey C. Baker, Elizabeth A. Strychalski, Kelley C. Rogers, Kelvin H. Lee
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 7 (2019)
Cyberbiosecurity is an emerging discipline that addresses the unique vulnerabilities and threats that occur at the intersection of cyberspace and biotechnology. Advances in technology and manufacturing are increasing the relevance of cyberbiosecurity
Externí odkaz:
https://doaj.org/article/9a9414ec906b4e9c95fe3bf0ff2c0e7f
Autor:
Joel T. Welch, N. Sarah Arden
Publikováno v:
Biologicals. 62:16-21
There has been much recent focus on the regulatory emphasis and the relative importance surrounding clonal derivation of mammalian production cell lines used in the manufacture of recombinant DNA-derived biopharmaceuticals. This interest has led to a
Autor:
Xianhua Cao, Marc R. Theoret, Meredith Libeg, Liang Zhao, Whitney S. Helms, Kun He, Laurie Graham, Richard Pazdur, Meredith K. Chuk, Hongshan Li, Joel T. Welch, Hong Zhao, Maitreyee Hazarika, Rajeshwari Sridhara, Alexander H. Putman, Sirisha Mushti, Shawna L. Weis, Patricia Keegan
Publikováno v:
Clinical Cancer Research. 23:3484-3488
On December 22, 2014, the FDA granted accelerated approval to nivolumab (OPDIVO; Bristol-Myers Squibb) for the treatment of patients with unresectable or metastatic melanoma and disease progression following ipilimumab and, if BRAF V600 mutation posi
Autor:
Joel T. Welch, Vincent Jacques, Heribert Schmitt-Willich, Jeffrey S. Troughton, Jaclyn M. Chasse, Peter Caravan, Stephane Dumas, Wei-Chuan Sun
Publikováno v:
Investigative Radiology. 45:600-612
Rationale and Objectives:The donor atoms that bind to gadolinium in contrast agents influence inner-sphere water exchange and electronic relaxation, both of which determine observed relaxivity. The effect of these molecular parameters on relaxivity i
Autor:
Welch, Joel T.1 (AUTHOR) Joel.Welch@fda.hhs.gov, Kozlowski, Steven1 (AUTHOR), Damdinsuren, Bazarragchaa1 (AUTHOR), Roelofs, Brian A.1 (AUTHOR)
Publikováno v:
AAPS Open. 8/1/2024, Vol. 10 Issue 1, p1-11. 11p.
Autor:
Sonya J. Franklin, Joel T. Welch
Publikováno v:
Comments on Inorganic Chemistry. 26:127-164
De novo design is a powerful tool to investigate the active site of enzymatic metalloproteins, in a smaller, defined model system. It is also a way to build or combine activity and selectivity in unique ways, not seen biologically. We are utilizing p
Publikováno v:
Inorganic chemistry. 42(24)
A series of Eu(III) metallopeptides, designed on the basis of the structural similarity of the helix-turn-helix and EF-hand motifs, have been studied by Eu(III) (7)F(0) --> (5)D(0) excitation spectroscopy. The impact of EF-hand ligand set differences
Publikováno v:
Journal of the American Chemical Society. 125(22)
A chimeric metallopeptide derived from the sequences of two structurally superimposable motifs was designed as an artificial nuclease. Both DNA recognition and nuclease activity have been incorporated into a small peptide sequence. P3W, a 33-mer pept
A designed lanthanide-binding chimeric peptide based on the strikingly similar geometries of the EF-hand and helix-turn-helix (HTH) motifs was investigated by NMR and CD spectroscopy and found to retain the same overall solution structure of the pare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b711215c1155846a3f6a6635e769b31
https://europepmc.org/articles/PMC152989/
https://europepmc.org/articles/PMC152989/