Zobrazeno 1 - 6 of 6 pro vyhledávání: '"Joel T. Gabre"'
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Akademický článek
Patient-derived organoids as a platform for modeling a patient’s response to chemoradiotherapy in esophageal cancer
Autor: Tatiana A. Karakasheva, Joel T. Gabre, Uma M. Sachdeva, Ricardo Cruz-Acuña, Eric W. Lin, Maureen DeMarshall, Gary W. Falk, Gregory G. Ginsberg, Zhaohai Yang, Michele M. Kim, Eric S. Diffenderfer, Jason R. Pitarresi, Jinyang Li, Amanda B. Muir, Kathryn E. Hamilton, Hiroshi Nakagawa, Adam J. Bass, Anil K. Rustgi
Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract 3D patient-derived organoids (PDOs) have been utilized to evaluate potential therapies for patients with different cancers. However, the use of PDOs created from treatment-naive patient biopsies for prediction of clinical outcomes in patient
Externí odkaz: https://doaj.org/article/43bca536a467471b9f4d262b3322f68e
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Engineered hydrogel reveals contribution of matrix mechanics to esophageal adenocarcinoma 3D organoids and identify matrix-activated therapeutic targets
Autor: Ricardo Cruz-Acuña, Secunda W. Kariuki, Kensuke Sugiura, Claudia Loebel, Tatiana Karakasheva, Joel T. Gabre, Jason A. Burdick, Anil K. Rustgi
Increased extracellular matrix (ECM) stiffness has been implicated in esophageal adenocarcinoma (EAC) progression, metastasis, and resistance to therapy. However, the underlying pro-tumorigenic pathways are yet to be defined. Additional work is neede
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e5fa1f22b7acb199e326bfc37260f0a2
https://doi.org/10.1101/2022.11.13.516357
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Short and long-term outcomes of prophylactic total gastrectomy in 54 consecutive individuals with germline pathogenic mutations in the CDH1 gene
Autor: Mason D. Stillman, Nicole Kusche, Sabrina Toledano, Kimberly J. Hilfrank, Changhwan Yoon, Joel T. Gabre, Sheila D. Rustgi, Chin Hur, Fay Kastrinos, Sandra W. Ryeom, Sam S. Yoon
Publikováno v: Journal of surgical oncology. 126(8)
Germline mutation of CDH1 is rare and leads to hereditary diffuse gastric cancer (DGC).Patients (pts) with CDH1 mutation who underwent multidisciplinary counseling followed by open prophylactic total gastrectomy (PTG) by a single surgeon were reviewe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adbe0209d30f48e130eb2ff0591976f6
https://pubmed.ncbi.nlm.nih.gov/36063148
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Abstract 3838: Engineered hydrogel elucidates contributions of matrix mechanics to esophageal adenocarcinoma and identify matrix-activated therapeutic targets
Autor: Ricardo Cruz-Acuña, Secunda W. Kariuki, Claudia Loebel, Tatiana Karakasheva, Joel T. Gabre, Jason A. Burdick, Anil K. Rustgi
Publikováno v: Cancer Research. 82:3838-3838
INTRODUCTION: Changes in the tumor microenvironment arbitrated by a stiffened ECM are associated with tumor aggression and enable increased propensity towards metastasis. For instance, in vitro (2D) studies have implicated ECM properties in EAC progr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::85e42c36caaae331cb7bedb13b04c546
https://doi.org/10.1158/1538-7445.am2022-3838
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