Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Joel T Rämö"'
Autor:
James P. Pirruccello, Paolo Di Achille, Seung Hoan Choi, Joel T. Rämö, Shaan Khurshid, Mahan Nekoui, Sean J. Jurgens, Victor Nauffal, Shinwan Kany, FinnGen, Kenney Ng, Samuel F. Friedman, Puneet Batra, Kathryn L. Lunetta, Aarno Palotie, Anthony A. Philippakis, Jennifer E. Ho, Steven A. Lubitz, Patrick T. Ellinor
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Increased left atrial volume and decreased left atrial function have long been associated with atrial fibrillation. The availability of large-scale cardiac magnetic resonance imaging data paired with genetic data provides a unique opportunit
Externí odkaz:
https://doaj.org/article/28dcb362d1d747399f72a9d9686b4b32
Autor:
Pietari Ripatti, Joel T Rämö, Sanni Söderlund, Ida Surakka, Niina Matikainen, Matti Pirinen, Päivi Pajukanta, Antti-Pekka Sarin, Susan K Service, Pirkka-Pekka Laurila, Christian Ehnholm, Veikko Salomaa, Richard K Wilson, Aarno Palotie, Nelson B Freimer, Marja-Riitta Taskinen, Samuli Ripatti
Publikováno v:
PLoS Genetics, Vol 12, Iss 5, p e1006078 (2016)
Familial combined hyperlipidemia (FCH) is a complex and common familial dyslipidemia characterized by elevated total cholesterol and/or triglyceride levels with over five-fold risk of coronary heart disease. The genetic architecture and contribution
Externí odkaz:
https://doaj.org/article/5198904350ad46738f987120e6f61325
Autor:
Elmo C. Saarentaus, Juha Karjalainen, Joel T. Rämö, Tuomo Kiiskinen, Aki S. Havulinna, Juha Mehtonen, Heidi Hautakangas, Sanni Ruotsalainen, Max Tamlander, Nina Mars, FINNGEN, Sanna Toppila-Salmi, Matti Pirinen, Mitja Kurki, Samuli Ripatti, Mark Daly, Tuula Palotie, Antti Mäkitie, Aarno Palotie
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
The shared genetics between upper respiratory diseases have not been well studied. Here, the authors find shared and distinct genetic loci for pharyngeal and sinonasal inflammatory conditions, which show shared heritability with autoimmune conditions
Externí odkaz:
https://doaj.org/article/cb22a6f5171944f8937a5a911c1a25ed
Autor:
Joel T. Rämö, Tuomo Kiiskinen, Richard Seist, Kristi Krebs, Masahiro Kanai, Juha Karjalainen, Mitja Kurki, Eija Hämäläinen, Paavo Häppölä, Aki S. Havulinna, Heidi Hautakangas, FinnGen, Reedik Mägi, Priit Palta, Tõnu Esko, Andres Metspalu, Matti Pirinen, Konrad J. Karczewski, Samuli Ripatti, Lili Milani, Konstantina M. Stankovic, Antti Mäkitie, Mark J. Daly, Aarno Palotie
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Otosclerosis is a common form of hearing loss, with an unclear genetic etiology. Here, the authors perform a genome-wide association study meta-analysis of otosclerosis identifying 27 genetic loci, pointing to genes involved in bone remodeling, skele
Externí odkaz:
https://doaj.org/article/6c545f6161e84ab58fce429684406cdc
Autor:
Rubina Tabassum, Joel T. Rämö, Pietari Ripatti, Jukka T. Koskela, Mitja Kurki, Juha Karjalainen, Priit Palta, Shabbeer Hassan, Javier Nunez-Fontarnau, Tuomo T. J. Kiiskinen, Sanni Söderlund, Niina Matikainen, Mathias J. Gerl, Michal A. Surma, Christian Klose, Nathan O. Stitziel, Hannele Laivuori, Aki S. Havulinna, Susan K. Service, Veikko Salomaa, Matti Pirinen, FinnGen Project, Matti Jauhiainen, Mark J. Daly, Nelson B. Freimer, Aarno Palotie, Marja-Riitta Taskinen, Kai Simons, Samuli Ripatti
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Cardiovascular diseases (CVD) are associated with plasma lipid levels. Here, Tabassum et al. perform genome-wide association studies for lipidomic profiles with 141 (non-standard) lipid species which highlights shared genetic loci with CVD and that t
Externí odkaz:
https://doaj.org/article/a7b6a56d3eec433f97120fae91d896c5
Autor:
Shinwan Kany, Joel T. Rämö, Cody Hou, Sean J. Jurgens, Victor Nauffal, Jon Cunningham, Emily S. Lau, Atul J. Butte, Jennifer E. Ho, Jeffrey E. Olgin, Sammy Elmariah, Mark E. Lindsay, Patrick T. Ellinor, James P. Pirruccello
Publikováno v:
medRxiv
Valvular heart disease is associated with a high global burden of disease. Even mild aortic stenosis confers increased morbidity and mortality, prompting interest in understanding normal variation in valvular function at scale.We developed a deep lea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3f8ef117daedc538e6c53727e0b5ef4
https://europepmc.org/articles/PMC10187336/
https://europepmc.org/articles/PMC10187336/
Autor:
James P. Pirruccello, Joel T. Rämö, Seung Hoan Choi, Mark D. Chaffin, Shinwan Kany, Mahan Nekoui, Elizabeth L. Chou, Sean J. Jurgens, Samuel F. Friedman, Dejan Juric, James R. Stone, Puneet Batra, Kenney Ng, Anthony A. Philippakis, Mark E. Lindsay, Patrick T. Ellinor
Publikováno v:
Journal of the American College of Cardiology, 81(14), 1320-1335. Elsevier USA
Background: As the largest conduit vessel, the aorta is responsible for the conversion of phasic systolic inflow from ventricular ejection into more continuous peripheral blood delivery. Systolic distention and diastolic recoil conserve energy and ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7901927b3e2a1d13ce68d78becfe62c
https://pure.amc.nl/en/publications/the-genetic-determinants-of-aortic-distention(0a67faa3-f7d9-4600-a240-abc53b9c22c4).html
https://pure.amc.nl/en/publications/the-genetic-determinants-of-aortic-distention(0a67faa3-f7d9-4600-a240-abc53b9c22c4).html
Autor:
Joel T. Rämö, Pietari Ripatti, Rubina Tabassum, Sanni Söderlund, Niina Matikainen, Mathias J. Gerl, Christian Klose, Michal A. Surma, Nathan O. Stitziel, Aki S. Havulinna, Matti Pirinen, Veikko Salomaa, Nelson B. Freimer, Matti Jauhiainen, Aarno Palotie, Marja‐Riitta Taskinen, Kai Simons, Samuli Ripatti
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 13 (2019)
Background We asked whether, after excluding familial hypercholesterolemia, individuals with high low‐density lipoprotein cholesterol (LDL‐C) or triacylglyceride levels and a family history of the same hyperlipidemia have greater coronary artery
Externí odkaz:
https://doaj.org/article/cf5345777bec45d59bdb177eb68eeeb9
Autor:
Xin Wang, Caitlin Selvaggi, Lu-Chen Weng, Sean J. Jurgens, Seung Hoan Choi, Anjali Jha, Tingyi Cao, Satoshi Koyama, Joel T. Rämö, Shinwan Kany, Patrick T. Ellinor, Andrea S. Foulkes, Steven A. Lubitz
Gene expression causally contributes to phenotypic variability. However, since tissue-specific gene expression is difficult to measure at scale, inferring phenotypic risk for individuals using expression profiles can be difficult. We statistically im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a823a837c9db93401ea48d68edb8e46
https://doi.org/10.1101/2022.11.23.22282644
https://doi.org/10.1101/2022.11.23.22282644
Autor:
Sakari, Jukarainen, Tuomo, Kiiskinen, Sara, Kuitunen, Aki S, Havulinna, Juha, Karjalainen, Mattia, Cordioli, Joel T, Rämö, Nina, Mars, Kaitlin E, Samocha, Hanna M, Ollila, Matti, Pirinen, Andrea, Ganna
Publikováno v:
Nature medicine. 28(9)
The impact of genetic variation on overall disease burden has not been comprehensively evaluated. We introduce an approach to estimate the effect of genetic risk factors on disability-adjusted life years (DALYs; 'lost healthy life years'). We use gen