Do Newly Born Orphan Proteins Resemble Never Born Proteins? A Study using Deep Learning Algorithms

Autor: Jing Liu, Rongqing Yuan, Wei Shao, Jitong Wang, Israel Silman, Joel Sussman

Newly Born proteins, devoid of detectable homology to any other proteins, known as orphan proteins, occur in a single species or within a taxonomically restricted gene family. They are generated by expression of novel Open Reading Frames, and appear

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6357bc15f725066bc62f4e6799388056
https://doi.org/10.22541/au.166004348.85176690/v1

Policies in Structural Genomics/ Structural Proteomics

Autor: Shigeyuki Yokoyama, David I. Stuart, Ian A. Wilson, Stephen K. Burley, Edward N. Baker, Dino Moras, Joel Sussman, Udo Heinemann, Thomas C. Terwilliger, Seiki Kuramitsu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a27b06299d724af1325db7c3abd94ccc
https://doi.org/10.1142/9789812772053_0020

Structure and dynamics of the active site gorge of acetylcholinesterase: synergistic use of molecular dynamics simulation and X-ray crystallography

Autor: Axelsen, P. H., Harel, M., Silman, I., Joel Sussman

Publikováno v: Scopus-Elsevier

The active site of acetylcholinesterase (AChE) from Torpedo californica is located 20 A from the enzyme surface at the bottom of a narrow gorge. To understand the role of this gorge in the function of AChE, we have studied simulations of its molecula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c760c2a3a7bab769a57a03b5f0b0fbb5
https://europepmc.org/articles/PMC2142791/

Differential effects of 'peripheral' site ligands on Torpedo and chicken acetylcholinesterase

Autor: Eichler, J., Anselmet, A., Joel Sussman, Massoulie, J., Silman, I.

Publikováno v: Scopus-Elsevier

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::2cbec3202e89c0198fc6fdecf659fb8b
http://www.scopus.com/inward/record.url?eid=2-s2.0-0028177161&partnerID=MN8TOARS

Soluble monomeric acetylcholinesterase from mouse: Expression, purification, and crystallization in complex with fasciculin

Autor: Marchot, P., Ravelli, R. B. G., Raves, M. L., Bourne, Y., Vellom, D. C., Kanter, J., Camp, S., Joel Sussman, Taylor, P.

Publikováno v: Scopus-Elsevier
Protein Science
Protein Science, 1996, 5 (4), pp.672-679. ⟨10.1002/pro.5560050411⟩
Protein Science, Wiley, 1996, 5 (4), pp.672-679. ⟨10.1002/pro.5560050411⟩

International audience; A soluble, monomeric form of acetylcholinesterase from mouse (mAChE), truncated at its carboxyl-terminal end, was generated from a cDNA encoding the glycophospholipid-linked form of the mouse enzyme by insertion of an early st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::300e426d01cb322b83ea208577826a02
http://www.scopus.com/inward/record.url?eid=2-s2.0-0029874624&partnerID=MN8TOARS