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Impaired expression of NADH dehydrogenase subunit 1 and PPARγ coactivator-1 in skeletal muscle of ZDF rats

Autor: Mireia Jové, Joel Salla, Anna Planavila, Àgatha Cabrero, Liliane Michalik, Walter Wahli, Juan C. Laguna, Manuel Vázquez-Carrera

Publikováno v: Journal of Lipid Research, Vol 45, Iss 1, Pp 113-123 (2004)

Type 2 diabetes has been related to a decrease of mitochondrial DNA (mtDNA) content. In this study, we show increased expression of the peroxisome proliferator-activated receptor-α (PPARα) and its target genes involved in fatty acid metabolism in s

Externí odkaz: https://doaj.org/article/b78e7176f6594d0ca2d32637ba580906

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Supplementary Data from Randomized Phase 0/I Trial of the Mitochondrial Inhibitor ME-344 or Placebo Added to Bevacizumab in Early HER2-Negative Breast Cancer

Autor: Silvana Mouron, Francisca Mulero, Eduardo Caleiras, Diego Malón, Juan Guerra, Javier Cortés, Antonio Lopez-Alonso, María Gion, Joel Salla Fortuny, Ariadna Gasol Cudos, Manuel Muñoz, Juan V. Apala, Luis Manso, Alfonso Cortés-Salgado, Serafín Morales, Miguel Quintela-Fandino

Supplementary material

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::542a66c4c343909e26d1145640c2e8e5
https://doi.org/10.1158/1078-0432.22475895.v1

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Figure S1 from Randomized Phase 0/I Trial of the Mitochondrial Inhibitor ME-344 or Placebo Added to Bevacizumab in Early HER2-Negative Breast Cancer

Supplementary Figure 1: Microvessel confocal staining broken down by fluorescence channel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a157e7aab0fba6805e9a15ee8e9edbe
https://doi.org/10.1158/1078-0432.22475901

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Data from Randomized Phase 0/I Trial of the Mitochondrial Inhibitor ME-344 or Placebo Added to Bevacizumab in Early HER2-Negative Breast Cancer

Purpose:We previously demonstrated that mitochondrial inhibitors' efficacy was restricted to a metabolic context in which mitochondrial respiration was the predominant energy source, a situation achievable by inducing vascular normalization/hypoxia c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cc3f985d5e8e7524e5de28637a2d268
https://doi.org/10.1158/1078-0432.c.6529209.v1

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Randomized Phase 0/I Trial of the Mitochondrial Inhibitor ME-344 or Placebo Added to Bevacizumab in Early HER2-Negative Breast Cancer

Autor: Miguel Quintela-Fandino, Juan Antonio Guerra, Juan V. Apala, María Gion, Francisca Mulero, Antonio Lopez-Alonso, Alfonso Cortés-Salgado, Diego Malón, Manuel Muñoz, Javier Cortes, Ariadna Gasol Cudós, Serafin Morales, Joel Salla Fortuny, Eduardo Caleiras, Luis Manso, Silvana Mouron

Publikováno v: Clinical Cancer Research. 26:35-45

Purpose: We previously demonstrated that mitochondrial inhibitors' efficacy was restricted to a metabolic context in which mitochondrial respiration was the predominant energy source, a situation achievable by inducing vascular normalization/hypoxia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1518fa51a7c103c4c3dc49118f530580
https://doi.org/10.1158/1078-0432.ccr-19-2023

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Role of gamma-delta T-cells in cancer. Another opening door to immunotherapy

Autor: Antonieta Salud-Salvia, Diego Marquez-Medina, Joel Salla-Fortuny

Publikováno v: Clinical and Translational Oncology. 14:891-895

The gamma-delta (γδ) T-cells are a subset of T-lymphocytes characterized by the presence of a surface antigen recognition complex type 2. Those γδ T-cells represent 2-5 % of peripheral T-cells only, but they are common in organs and mucosae, acti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74ca9245a9e5f3443340aee50e4dccfe
https://doi.org/10.1007/s12094-012-0935-7

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Forensic analysis of dog (Canis lupus familiaris) mitochondrial DNA sequences: An inter-laboratory study of the GEP-ISFG working group

Publikováno v: Forensic Science International: Genetics. 4:49-54

A voluntary collaborative exercise aiming at the mitochondrial analysis of canine biological samples was carried out in 2006-2008 by the Non-Human Forensic Genetics Commission of the Spanish and Portuguese Working Group (GEP) of the International Soc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9582c39e7f8c2cb163c5b132a80445a1
https://doi.org/10.1016/j.fsigen.2009.04.008

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Impaired expression of NADH dehydrogenase subunit 1 and PPARγ coactivator-1 in skeletal muscle of ZDF rats

Autor: Juan C. Laguna, Anna Planavila, Walter Wahli, Joel Salla, Liliane Michalik, Àgatha Cabrero, Mireia Jové, Manuel Vázquez-Carrera

Publikováno v: Journal of Lipid Research, Vol 45, Iss 1, Pp 113-123 (2004)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9bc5c5a7db00f423654a682252504d4
http://www.sciencedirect.com/science/article/pii/S0022227520319271

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Impaired expression of NADH dehydrogenase subunit 1 and PPARgamma coactivator-1 in skeletal muscle of ZDF rats: restoration by troglitazone

Autor: Mireia, Jové, Joel, Salla, Anna, Planavila, Agatha, Cabrero, Liliane, Michalik, Walter, Wahli, Juan C, Laguna, Manuel, Vázquez-Carrera

Publikováno v: Journal of lipid research. 45(1)

Type 2 diabetes has been related to a decrease of mitochondrial DNA (mtDNA) content. In this study, we show increased expression of the peroxisome proliferator-activated receptor-alpha (PPARalpha) and its target genes involved in fatty acid metabolis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1691de8571ef4720901c4ce1582dc35f
https://pubmed.ncbi.nlm.nih.gov/14563825

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