Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Joel S. Rimes"'
Autor:
Georgia K. Atkin-Smith, Jascinta P. Santavanond, Amanda Light, Joel S. Rimes, Andre L. Samson, Jeremy Er, Joy Liu, Darryl N. Johnson, Mélanie Le Page, Pradeep Rajasekhar, Raymond K. H. Yip, Niall D. Geoghegan, Kelly L. Rogers, Catherine Chang, Vanessa L. Bryant, Mai Margetts, M. Cristina Keightley, Trevor J. Kilpatrick, Michele D. Binder, Sharon Tran, Erinna F. Lee, Walter D. Fairlie, Dilara C. Ozkocak, Andrew H. Wei, Edwin D. Hawkins, Ivan K. H. Poon
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Endothelial cells are integral components of all vasculature within complex organisms. As they line the blood vessel wall, endothelial cells are constantly exposed to a variety of molecular factors and shear force that can induce cellular da
Externí odkaz:
https://doaj.org/article/12adadfbad504a22aba93116f2876b03
Autor:
Raymond K. H. Yip, Joel S. Rimes, Bianca D. Capaldo, François Vaillant, Kellie A. Mouchemore, Bhupinder Pal, Yunshun Chen, Elliot Surgenor, Andrew J. Murphy, Robin L. Anderson, Gordon K. Smyth, Geoffrey J. Lindeman, Edwin D. Hawkins, Jane E. Visvader
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The visualisation of the bone metastasis process in a spatial temporal manner is lacking. Here, the authors use three-dimensional quantitative imaging and show that mouse mammary tumour cells preferentially home to endothelial subtype type H vessels
Externí odkaz:
https://doaj.org/article/938d0b41436b4974bba32259f0e9856a
Autor:
Isabella Y. Kong, Joel S. Rimes, Amanda Light, Izabela Todorovski, Sarah Jones, Eric Morand, Deborah A. Knight, Ylva E. Bergman, Simon J. Hogg, Hendrik Falk, Brendon J. Monahan, Paul A. Stupple, Ian P. Street, Susanne Heinzel, Philippe Bouillet, Ricky W. Johnstone, Philip D. Hodgkin, Stephin J. Vervoort, Edwin D. Hawkins
Publikováno v:
Cell Reports, Vol 33, Iss 3, Pp 108290- (2020)
Summary: JQ1 is a BET-bromodomain inhibitor that has immunomodulatory effects. However, the precise molecular mechanism that JQ1 targets to elicit changes in antibody production is not understood. Our results show that JQ1 induces apoptosis, reduces
Externí odkaz:
https://doaj.org/article/ee968f52f07046a6b68bf519b3e86ce7
Autor:
Christopher R Horne, Kelly L. Rogers, Joanne M Hildebrand, Xavier J Gavin, Komal Patel, James M. Murphy, Samuel N. Young, Edwin D. Hawkins, Lachlan Whitehead, Cheree Fitzgibbon, Annette V. Jacobsen, Joel S. Rimes, Andre L. Samson
Publikováno v:
Cell Death Differ
Necroptosis is a lytic, inflammatory cell death pathway that is dysregulated in many human pathologies. The pathway is executed by a core machinery comprising the RIPK1 and RIPK3 kinases, which assemble into necrosomes in the cytoplasm, and the termi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::858665f77f3b2a137f0d96dd7c7e3b50
https://doi.org/10.1038/s41418-021-00742-x
https://doi.org/10.1038/s41418-021-00742-x
Autor:
Geoffrey J. Lindeman, Kellie A. Mouchemore, Robin L. Anderson, Yunshun Chen, Elliot Surgenor, Bhupinder Pal, Joel S. Rimes, Raymond K H Yip, Andrew J. Murphy, Edwin D. Hawkins, Bianca D. Capaldo, Gordon K. Smyth, François Vaillant, Jane E. Visvader
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Bone marrow is a preferred metastatic site for multiple solid tumours and is associated with poor prognosis and significant morbidity. Accumulating evidence indicates that cancer cells colonise specialised niches within the bone marrow to support the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca6d342dc17b7ada09e2480790a62fba
http://europepmc.org/articles/PMC8626461
http://europepmc.org/articles/PMC8626461
Autor:
Andre L. Samson, Samuel N. Young, Komal Patel, Joanne M Hildebrand, Christopher R Horne, James M. Murphy, Lachlan Whitehead, Kelly L. Rogers, Xavier J Gavin, Annette V. Jacobsen, Edwin D. Hawkins, Cheree Fitzgibbon, Joel S. Rimes
Necroptosis is a lytic, inflammatory cell death pathway that is dysregulated in many human pathologies. The pathway is executed by a core machinery comprising the RIPK1 and RIPK3 kinases, which assemble into necrosomes in the cytoplasm, and the termi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92bcb4d826dde4c2366de2969d042071
https://doi.org/10.1101/2020.10.26.356063
https://doi.org/10.1101/2020.10.26.356063
Autor:
Joel S. Rimes, Ashley P. Ng, Mikara Robati, Hai Vu Nguyen, Natasha S Anstee, Suzanne Cory, Edwin D. Hawkins, Cassandra J. Vandenberg
Publikováno v:
Blood.
MNT is a member of the MYC transcription factor network of proteins(1) that must heterodimerize with MYC-associated factor X, or MAX for short, to bind certain DNA recognition motifs in gene promoters that regulate gene expression. Because many targe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e31f0321ecad686ef8c69ca544517037
https://doi.org/10.1182/blood.2019003014
https://doi.org/10.1182/blood.2019003014
Autor:
Philippe Bouillet, Derek Lacey, Lachlan Whitehead, Michael D. Stutz, Edwin D. Hawkins, Gabrielle T. Belz, Cyril Seillet, Ben Roediger, Elysa Carr, Joel S. Rimes, Marc Pellegrini
Publikováno v:
Immunology and Cell Biology
BPSM1 (Bone phenotype spontaneous mutant 1) mice develop severe polyarthritis and heart valve disease as a result of a spontaneous mutation in the Tnf gene. In these mice, the insertion of a retrotransposon in the 3' untranslated region of Tnf causes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63ecdfaa282ec49949f54cfbd51af827
https://doi.org/10.1111/imcb.12197
https://doi.org/10.1111/imcb.12197
Autor:
Pradnya Gangatirkar, Daniela Amann-Zalcenstein, Alison Farley, Caleb A. Dawson, Olivia Stonehouse, Warren S. Alexander, Samir Taoudi, Shalin H. Naik, Emma C. Josefsson, Casey Anttila, Carolyn A. de Graaf, Christine Biben, Joel S. Rimes, Douglas J. Hilton, Edwin D. Hawkins, Margaret A Potts, Amandine Carmagnac, Kathryn S. Potts
Publikováno v:
The Journal of Experimental Medicine
Whether proplatelet formation alone can explain physiological platelet production is unclear. Large-scale in situ analysis reveals that megakaryocytes undergo platelet biogenesis via membrane budding. Mathematically, membrane budding provides a robus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dea6a0ee884d4a2f39500ea078a6b7d4
https://pubmed.ncbi.nlm.nih.gov/32706855
https://pubmed.ncbi.nlm.nih.gov/32706855
Autor:
Paul Stupple, Deborah A. Knight, Ian P. Street, Isabella Y. Kong, Sarah Jones, Ylva Elisabet Bergman, Hendrik Falk, Philip D. Hodgkin, Joel S. Rimes, Edwin D. Hawkins, Stephin J. Vervoort, Eric F Morand, Ricky W. Johnstone, Brendon J. Monahan, Philippe Bouillet, Izabela Todorovski, Susanne Heinzel, Amanda Light, Simon J. Hogg
Publikováno v:
Cell Reports, Vol 33, Iss 3, Pp 108290-(2020)
Summary: JQ1 is a BET-bromodomain inhibitor that has immunomodulatory effects. However, the precise molecular mechanism that JQ1 targets to elicit changes in antibody production is not understood. Our results show that JQ1 induces apoptosis, reduces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee607531a57a34860cf7786d3b8b8d09
https://pubmed.ncbi.nlm.nih.gov/33086063
https://pubmed.ncbi.nlm.nih.gov/33086063