Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Joel S. Owen"'
Autor:
Kayla Ann Andrews, Joel S. Owen, James McCarthy, David Wesche, Nathalie Gobeau, Thaddeus H. Grasela, Jörg J. Möhrle
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 2, Pp 712-719 (2021)
Volunteer infection studies using the induced blood stage malaria (IBSM) model have been shown to facilitate antimalarial drug development. Such studies have traditionally been undertaken in single‐dose cohorts, as many as necessary to obtain the d
Externí odkaz:
https://doaj.org/article/93783e4eaa594480a2a823f11ef11c07
Autor:
Jackson K Mukonzo, Joel S Owen, Jasper Ogwal-Okeng, Ronald B Kuteesa, Sarah Nanzigu, Nelson Sewankambo, Lehana Thabane, Lars L Gustafsson, Colin Ross, Eleni Aklillu
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86919 (2014)
Pharmacogenetics contributes to inter-individual variability in pharmacokinetics (PK) of efavirenz (EFV), leading to variations in both efficacy and toxicity. The purpose of this study was to assess the effect of genetic factors on EFV pharmacokineti
Externí odkaz:
https://doaj.org/article/602a67e68d41418785d8d94fc2b01b03
Autor:
James S. McCarthy, Kayla Ann Andrews, Nathalie Gobeau, Joel S. Owen, Thaddeus H. Grasela, David Wesche, Jörg J. Möhrle
Publikováno v:
Clinical and Translational Science
Clinical and Translational Science, Vol 14, Iss 2, Pp 712-719 (2021)
Clinical and Translational Science, Vol 14, Iss 2, Pp 712-719 (2021)
Volunteer infection studies using the induced blood stage malaria (IBSM) model have been shown to facilitate antimalarial drug development. Such studies have traditionally been undertaken in single‐dose cohorts, as many as necessary to obtain the d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::417d66abdd5597ecd9557ab5c9a79fde
https://pubmed.ncbi.nlm.nih.gov/33326705
https://pubmed.ncbi.nlm.nih.gov/33326705
Dose–response and Cardiopulmonary Side Effects of the Novel Neuromuscular-blocking Drug CW002 in Man
Autor:
John J. Savarese, Peter M. Savard, Paul M. Heerdt, Jaideep K. Malhotra, Hiroshi Sunaga, Deena Godfrey, Joel S. Owen, Matthew T. Murrell, Michelle Steinkamp, Cynthia A. Lien
Publikováno v:
Anesthesiology. 125:1136-1143
BackgroundCW002 is a benzylisoquinolinium nondepolarizing neuromuscular-blocking drug found to be inactivated by cysteine in preclinical studies. The current study represents a dose escalation clinical trial designed to describe CW002 potency, durati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf0d3fd263b593d5b970f5b5f2bdf4bb
https://doi.org/10.1097/aln.0000000000001386
https://doi.org/10.1097/aln.0000000000001386
Autor:
Getachew Aderaye, Wondwossen Amogne, Leif Bertilsson, Joel S. Owen, Getnet Yimer, Eyasu Makonnen, Eleni Aklillu, Abiy Habtewold, Jürgen Burhenne
Publikováno v:
The Journal of Clinical Pharmacology. 56:1538-1549
We compared the pharmacokinetic (PK) exposure parameters of efavirenz (EFV) and its major inactive metabolite, 8-hydroxy-efavirenz (8-OH-EFV), in an open-label, single-sequence, and parallel design of HIV-infected and tuberculosis (TB)-HIV-coinfected
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd50fbab4462f26173efec976786b73e
https://doi.org/10.1002/jcph.756
https://doi.org/10.1002/jcph.756
Autor:
Joel S. Owen, Eleni Aklillu, Jasper Ogwal-Okeng, Ronald K Bisaso, Lars L. Gustafsson, Jackson K. Mukonzo
Publikováno v:
Pharmacogenomics. 17:603-613
Aim: To assess genotype effect on efavirenz (EFV) pharmacokinetics, treatment outcomes and provide genotype-based EFV doses recommendations during for tuberculosis (TB)-HIV-1 cotreatment. Materials & methods: EFV concentrations from 158 HIV-TB co-inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59161e2e6e13fd1f93cab164f89b8b77
https://doi.org/10.2217/pgs.16.7
https://doi.org/10.2217/pgs.16.7
Autor:
Kim L. R. Brouwer, Cynthia A. Lien, Virginia D. Schmith, Joel S. Owen, Paul M. Heerdt, Josh D. Kaullen, John J. Savarese
Publikováno v:
Anesthesiology. 128(6)
BackgroundCW002 is an investigational nondepolarizing, neuromuscular blocking agent with a rapid onset and intermediate duration of action in animals. This is a single ascending dose, healthy subject study exploring tolerability, pharmacokinetics, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccb43f0d32310f9521ee502a7a1c0f2a
https://pubmed.ncbi.nlm.nih.gov/29494403
https://pubmed.ncbi.nlm.nih.gov/29494403
Autor:
Getnet Yimer, Eyasu Makonnen, Eleni Aklillu, Jürgen Burhenne, Leif Bertilsson, Joel S. Owen, Abiy Habtewold
Publikováno v:
Antimicrobial Agents and Chemotherapy. 61
The objectives of this study were to characterize the population pharmacokinetics (PK) of efavirenz (EFV) and 8-hydroxy-efavirenz (8OHEFV) in plasma and peripheral blood mononuclear cells (PBMCs) and to explore covariates affecting the PK parameters.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0cd1014130eec8001965fb82a7b8a88
https://doi.org/10.1128/aac.00207-17
https://doi.org/10.1128/aac.00207-17
Autor:
Ole Snyder, Steven Chavoustie, Mona Darwish, Ryan Dammerman, Michael Frost, Joel S. Owen, Victoria Sanjurjo
Publikováno v:
Expert review of clinical pharmacology. 10(8)
Opioid use disorder is a chronic, relapsing disease that encompasses use of both prescription opioids and heroin and is associated with a high annual rate of overdose deaths. Medical treatment has proven more successful than placebo treatment or psyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66f3f898d92342d6eee59efc5184b181
https://pubmed.ncbi.nlm.nih.gov/28571505
https://pubmed.ncbi.nlm.nih.gov/28571505
Autor:
Joel S. Owen, Lineau Vilson
Publikováno v:
Clinical Pharmacology in Drug Development. 2:25-32
Guaifenesin is an expectorant used to improve mucociliary clearance (MCC) and relieve chest congestion from upper respiratory tract infections. Immediate-release (IR) guaifenesin requires dosing every 4 hours to maintain efficacy because of the drug'
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aea0451c066ad66940427bcb72b1dda8
https://doi.org/10.1002/cpdd.8
https://doi.org/10.1002/cpdd.8