Zobrazeno 1 - 10
of 239
pro vyhledávání: '"Joel S. Karliner"'
Autor:
David H Lovett, Rajeev Mahimkar, Robert L Raffai, Leslie Cape, Bo-Qing Zhu, Zhu-Qiu Jin, Anthony J Baker, Joel S Karliner
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68154 (2013)
Matrix metalloproteinase-2 (MMP-2) is increasingly recognized as a major contributor to progressive cardiac injury within the setting of ischemia-reperfusion injury and ischemic ventricular remodeling. A common feature of these conditions is an incre
Externí odkaz:
https://doaj.org/article/389d7976b2464c7e93cdd5bcec7e1bda
Autor:
David H Lovett, Rajeev Mahimkar, Robert L Raffai, Leslie Cape, Elena Maklashina, Gary Cecchini, Joel S Karliner
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34177 (2012)
Experimental and clinical evidence has pinpointed a critical role for matrix metalloproteinase-2 (MMP-2) in ischemic ventricular remodeling and systolic heart failure. Prior studies have demonstrated that transgenic expression of the full-length, 68
Externí odkaz:
https://doaj.org/article/df28ddd0db0c4fc59120878ac0fa81ad
Autor:
Kathryn Bauerly, Calliandra Harris, Winyoo Chowanadisai, James Graham, Peter J Havel, Eskouhie Tchaparian, Mike Satre, Joel S Karliner, Robert B Rucker
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e21779 (2011)
We have reported that pyrroloquinoline quinone (PQQ) improves reproduction, neonatal development, and mitochondrial function in animals by mechanisms that involve mitochondrial related cell signaling pathways. To extend these observations, the influe
Externí odkaz:
https://doaj.org/article/3a08a21fed74408484e1a9dfaf2536d5
Autor:
Sunil K. Joshi, Fu Sang Luk, Isabella Imhof, Daniel Ching, Roy Y Kim, Robert L. Raffai, Holly Hoover, Bo-Qing Zhu, Joel S. Karliner, Kang Li, David K. Wong, David H. Lovett, Norman Honbo
Publikováno v:
Journal of cardiovascular pharmacology, vol 67, iss 1
AIMS:We recently reported that immunosuppression with FTY720 improves cardiac function and extends longevity in Hypomorphic ApoE mice deficient in scavenger receptor Type-BI expression, also known as the HypoE/SR-BI(–/–) mouse model of diet-induc
Autor:
Joel S. Karliner
Publikováno v:
Biochimica et biophysica acta, vol 1831, iss 1
Activation of sphingosine kinase/sphingosine 1-phosphate (SK/S1P)-mediated signaling has emerged as a critical cardioprotective pathway in response to acute ischemia/reperfusion injury. S1P is released in both ischemic pre- and post-conditioning. App
Publikováno v:
Medical Science Monitor Basic Research
BACKGROUND We investigated the hypothesis that postconditioning by FTY720 (FTY) in isolated perfused mouse hearts is independent of the sphingosine 1-phosphate (S1P) pathway. MATERIAL AND METHODS Ex vivo hearts were exposed to postconditioning (POST)
Platelet-derived exosomes mediate platelet atherogenic interactions with endothelial cells and monocytes. A new method for isolation of plasma platelet-derived exosomes is described and used to examine effects of aging and aspirin on exosome cargo pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65fc08261d347b5cae6282a5b2b40a23
https://europepmc.org/articles/PMC4836374/
https://europepmc.org/articles/PMC4836374/
Autor:
Norman Honbo, Padmavathi Bandhuvula, Julie D. Saba, Guanying Wang, Henrik Fyrst, Alexander D. Borowsky, Meng Zhang, Zhu-Qiu Jin, Joel S. Karliner, Lisa M. Dillard
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 300:H1753-H1761
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that promotes cardiomyocyte survival and contributes to ischemic preconditioning. S1P lyase (SPL) is a stress-activated enzyme responsible for irreversible S1P catabolism. We hypothesized that
Autor:
Joel S. Karliner
Publikováno v:
Circulation. 129:2368-2370
A major pharmaceutical success story of the late 20th century was the introduction of statins into clinical medicine. This class of drugs (the firefighters) has contributed to reduced morbidity and mortality from atherosclerotic cardiovascular diseas
Publikováno v:
International Journal of Experimental Pathology. 92:50-56
Coronary artery ectasia (CAE) is generally diagnosed in patients undergoing arteriography for presumptive atherosclerotic coronary artery disease. CAE is commonly considered as a variant of atherosclerotic disease; however, recent studies suggest tha