Zobrazeno 1 - 10
of 393
pro vyhledávání: '"Joel S. Brown"'
Autor:
Darcy L. Welch, Brooke L. Fridley, Ling Cen, Jamie K. Teer, Sean J. Yoder, Fredrik Pettersson, Liping Xu, Chia-Ho Cheng, Yonghong Zhang, Mark G. Alexandrow, Shengyan Xiang, Mark Robertson-Tessi, Joel S. Brown, Jonathan Metts, Andrew S. Brohl, Damon R. Reed
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Osteosarcoma is the most common bone sarcoma in children and young adults. While universally delivered, chemotherapy only benefits roughly half of patients with localized disease. Increasingly, intratumoral heterogeneity is recognized as a s
Externí odkaz:
https://doaj.org/article/f7513fb0926f4a94b84dd06a5b81bbee
Autor:
Anuraag Bukkuri, Kenneth J. Pienta, Robert H. Austin, Emma U. Hammarlund, Sarah R. Amend, Joel S. Brown
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract The polyaneuploid cancer cell (PACC) state promotes cancer lethality by contributing to survival in extreme conditions and metastasis. Recent experimental evidence suggests that post-therapy PACC-derived recurrent populations display cross-r
Externí odkaz:
https://doaj.org/article/bcbd6c09da064051a756848a4f23f88c
Autor:
Jean‐Pascal Capp, Frédéric Thomas, Andriy Marusyk, Antoine M. Dujon, Sophie Tissot, Robert Gatenby, Benjamin Roche, Beata Ujvari, James DeGregori, Joel S. Brown, Aurora M. Nedelcu
Publikováno v:
Evolutionary Applications, Vol 16, Iss 7, Pp 1239-1256 (2023)
Abstract It is traditionally assumed that during cancer development, tumor cells abort their initially cooperative behavior (i.e., cheat) in favor of evolutionary strategies designed solely to enhance their own fitness (i.e., a “selfish” life sty
Externí odkaz:
https://doaj.org/article/40f663a816d647f3bbcfcd57342f99de
Autor:
Anuraag Bukkuri, Joel S. Brown
Publikováno v:
Methods in Ecology and Evolution, Vol 14, Iss 6, Pp 1475-1488 (2023)
Abstract State‐structured populations are ubiquitous in biology, from the age‐structure of animal societies to the life cycles of parasitic species. Understanding how this structure contributes to eco‐evolutionary dynamics is critical not only
Externí odkaz:
https://doaj.org/article/f5185b2413cf47558820f86f7965ec5a
Autor:
Anuraag Bukkuri, Kenneth J. Pienta, Sarah R. Amend, Robert H. Austin, Emma U. Hammarlund, Joel S. Brown
Publikováno v:
Ecology and Evolution, Vol 13, Iss 10, Pp n/a-n/a (2023)
Abstract Evolvability is the capacity of a population to generate heritable variation that can be acted upon by natural selection. This ability influences the adaptations and fitness of individual organisms. By viewing this capacity as a trait, evolv
Externí odkaz:
https://doaj.org/article/7e4d9299408e4b9199e84cb6dae86b05
Autor:
Anuraag Bukkuri, Kenneth J. Pienta, Robert H. Austin, Emma U. Hammarlund, Sarah R. Amend, Joel S. Brown
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Therapeutic resistance is one of the main reasons for treatment failure in cancer patients. The polyaneuploid cancer cell (PACC) state has been shown to promote resistance by providing a refuge for cancer cells from the effects of therapy an
Externí odkaz:
https://doaj.org/article/5e255d74321e44159eab4104663af1f8
Autor:
Anuraag Bukkuri, Kenneth J. Pienta, Robert H. Austin, Emma U. Hammarlund, Sarah R. Amend, Joel S. Brown
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Recent evidence suggests that a polyaneuploid cancer cell (PACC) state may play a key role in the adaptation of cancer cells to stressful environments and in promoting therapeutic resistance. The PACC state allows cancer cells to pause cell
Externí odkaz:
https://doaj.org/article/f9e258e630024871bac773c4cd734baa
Publikováno v:
npj Systems Biology and Applications, Vol 8, Iss 1, Pp 1-13 (2022)
Abstract The tragedy of the commons occurs when competition among individual members of a group leads to overexploitation of a shared resource to the detriment of the overall population. We hypothesize that cancer cells may engage in a tragedy of the
Externí odkaz:
https://doaj.org/article/350476ca1f5b4d3a9f3e5a1f82bc87fb
Autor:
Stephanie Chancellor, Bret Grasse, Taylor Sakmar, David Scheel, Joel S. Brown, Rachel M. Santymire
Publikováno v:
Animals, Vol 13, Iss 19, p 3115 (2023)
Our goal was to validate the use of dermal swabs to evaluate both reproductive and stress physiology in the California two-spot octopus, Octopus bimaculoides. Our objectives were to (1) use dermal swabs to evaluate glucocorticoids and reproductive ho
Externí odkaz:
https://doaj.org/article/d6ff34be3faa45eda3a07bd7c73f1580
Autor:
Dominique Abrahams, Arig Ibrahim-Hashim, Robert S. Ackerman, Joel S. Brown, Christopher J. Whelan, Megan B. Garfinkel, Robert A. Gatenby, Aaron R. Muncey
Publikováno v:
PLoS ONE, Vol 18, Iss 10 (2023)
Externí odkaz:
https://doaj.org/article/5b129c4e2b514cb7935c8765635f9de3