Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Joel S Freundlich"'
Autor:
Richard C Lavin, Calvin Johnson, Yong-Mo Ahn, Kyle M Kremiller, Matthew Sherwood, Jimmy S Patel, Yan Pan, Riccardo Russo, Nathan J MacGilvary, David Giacalone, Yuzo L Kevorkian, Matthew D Zimmerman, J Fraser Glickman, Joel S Freundlich, Shumin Tan
Publikováno v:
PLoS Biology, Vol 19, Iss 7, p e3001355 (2021)
Sensing and response to environmental cues, such as pH and chloride (Cl-), is critical in enabling Mycobacterium tuberculosis (Mtb) colonization of its host. Utilizing a fluorescent reporter Mtb strain in a chemical screen, we have identified compoun
Externí odkaz:
https://doaj.org/article/e8e92b4c6c2a4557821d17bd95672572
Autor:
Ravindra Jadhav, Ricardo Gallardo-Macias, Gaurav Kumar, Samer S Daher, Amit Kaushik, Kristina M Bigelow, Eric L Nuermberger, Gyanu Lamichhane, Joel S Freundlich
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0249841 (2021)
We present further study of a subset of carbapenems, arising from a previously reported machine learning approach, with regard to their mouse pharmacokinetic profiling and subsequent study in a mouse model of sub-acute Mycobacterium tuberculosis infe
Externí odkaz:
https://doaj.org/article/69535c1c1e5b45e6b864c3a87b820f15
Autor:
Thomas R Lane, Christopher Massey, Jason E Comer, Manu Anantpadma, Joel S Freundlich, Robert A Davey, Peter B Madrid, Sean Ekins
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 13, Iss 11, p e0007890 (2019)
Recent outbreaks of the Ebola virus (EBOV) have focused attention on the dire need for antivirals to treat these patients. We identified pyronaridine tetraphosphate as a potential candidate as it is an approved drug in the European Union which is cur
Externí odkaz:
https://doaj.org/article/848b3e0787cd4db1b567389b6f045122
Autor:
Evan J Waldron, Daniel Snyder, Nicolas L Fernandez, Emily Sileo, Daigo Inoyama, Joel S Freundlich, Christopher M Waters, Vaughn S Cooper, Matthew B Neiditch
Publikováno v:
PLoS Biology, Vol 17, Iss 2, p e3000123 (2019)
The diffusible signal factors (DSFs) are a family of quorum-sensing autoinducers (AIs) produced and detected by numerous gram-negative bacteria. The DSF family AIs are fatty acids, differing in their acyl chain length, branching, and substitution but
Externí odkaz:
https://doaj.org/article/06ce77593e49429aa54d968eea42d331
Autor:
Xueyi Chen, Bhavatharini Arun, Oscar J. Nino-Meza, Mona O. Sarhan, Medha Singh, Byeonghoon Jeon, Kishor Mane, Maunank Shah, Elizabeth W. Tucker, Laurence S. Carroll, Joel S. Freundlich, Charles A. Peloquin, Vijay D. Ivaturi, Sanjay K. Jain
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Tuberculosis (TB) remains a leading cause of death, but antibiotic treatments for tuberculous meningitis, the deadliest form of TB, are based on those developed for pulmonary TB and not optimized for brain penetration. Here, we perform first
Externí odkaz:
https://doaj.org/article/12b747e27b024b34afbe5771b810380b
Autor:
Sean Ekins, Daniel Mietchen, Megan Coffee, Thomas P Stratton, Joel S Freundlich, Lucio Freitas-Junior, Eugene Muratov, Jair Siqueira-Neto, Antony J Williams, Carolina Andrade
Publikováno v:
F1000Research, Vol 5 (2016)
The Zika virus (ZIKV) outbreak in the Americas has caused global concern that we may be on the brink of a healthcare crisis. The lack of research on ZIKV in the over 60 years that we have known about it has left us with little in the way of starting
Externí odkaz:
https://doaj.org/article/a25d8021d75548d2a69e93f71fdc0e14
Autor:
Lauren Forbes, Katherine Ebsworth-Mojica, Louis DiDone, Shao-Gang Li, Joel S Freundlich, Nancy Connell, Paul M Dunman, Damian J Krysan
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129234 (2015)
Mycobacterium tuberculosis (Mtb) is well-established to be one of the most important bacterial pathogens for which new antimicrobial therapies are needed. Herein, we describe the development of a high throughput screening assay for the identification
Externí odkaz:
https://doaj.org/article/060bff0cd9594b89817399735d136871
Autor:
Sean Ekins, Peter B Madrid, Malabika Sarker, Shao-Gang Li, Nisha Mittal, Pradeep Kumar, Xin Wang, Thomas P Stratton, Matthew Zimmerman, Carolyn Talcott, Pauline Bourbon, Mike Travers, Maneesh Yadav, Joel S Freundlich
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0141076 (2015)
Integrated computational approaches for Mycobacterium tuberculosis (Mtb) are useful to identify new molecules that could lead to future tuberculosis (TB) drugs. Our approach uses information derived from the TBCyc pathway and genome database, the Col
Externí odkaz:
https://doaj.org/article/ba8bcfee67d346ddae5ce987ea3cb3cf
Autor:
Reem R Al Olaby, Laurence Cocquerel, Adam Zemla, Laure Saas, Jean Dubuisson, Jost Vielmetter, Joseph Marcotrigiano, Abdul Ghafoor Khan, Felipe Vences Catalan, Alexander L Perryman, Joel S Freundlich, Stefano Forli, Shoshana Levy, Rod Balhorn, Hassan M Azzazy
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e111333 (2014)
Hepatitis C Virus (HCV) infects 200 million individuals worldwide. Although several FDA approved drugs targeting the HCV serine protease and polymerase have shown promising results, there is a need for better drugs that are effective in treating a br
Externí odkaz:
https://doaj.org/article/8b68f68916394776b203292170c32fca
Autor:
Sean Ekins, Robert C Reynolds, Scott G Franzblau, Baojie Wan, Joel S Freundlich, Barry A Bunin
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63240 (2013)
High-throughput screening (HTS) in whole cells is widely pursued to find compounds active against Mycobacterium tuberculosis (Mtb) for further development towards new tuberculosis (TB) drugs. Hit rates from these screens, usually conducted at 10 to 2
Externí odkaz:
https://doaj.org/article/efd55384d95a4a5ab5862d98b6bb7323