Zobrazeno 1 - 10
of 372
pro vyhledávání: '"Joel S Brown"'
Immunomodulatory and pro-oncologic effects of ketamine and isoflurane anesthetics in a murine model.
Autor:
Dominique Abrahams, Arig Ibrahim-Hashim, Robert S Ackerman, Joel S Brown, Christopher J Whelan, Megan B Garfinkel, Robert A Gatenby, Aaron R Muncey
Publikováno v:
PLoS ONE, Vol 18, Iss 10, p e0292492 (2023)
IntroductionVolatile and intravenous anesthetics may worsen oncologic outcomes in basic science animal models. These effects may be related to suppressed innate and adaptive immunity, decreased immunosurveillance, and disrupted cellular signaling. We
Externí odkaz:
https://doaj.org/article/89ccfa288f7a45ea995a2eb332830cff
Autor:
Péter Bayer, Robert A Gatenby, Patricia H McDonald, Derek R Duckett, Kateřina Staňková, Joel S Brown
Publikováno v:
PLoS ONE, Vol 17, Iss 1, p e0261578 (2022)
We propose a model of cancer initiation and progression where tumor growth is modulated by an evolutionary coordination game. Evolutionary games of cancer are widely used to model frequency-dependent cell interactions with the most studied games bein
Externí odkaz:
https://doaj.org/article/7b6a2c89ad884d0d987be3628de097f3
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0245255 (2021)
Fish populations subject to heavy exploitation are expected to evolve over time smaller average body sizes. We introduce Stackelberg evolutionary game theory to show how fisheries management should be adjusted to mitigate the potential negative effec
Externí odkaz:
https://doaj.org/article/7bc82f72e1cf4973b529d5297ac161d3
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0200672 (2018)
Desert communities world-wide are used as natural laboratories for the study of convergent evolution, yet inferences drawn from such studies are necessarily indirect. Here, we brought desert organisms together (rodents and vipers) from two deserts (M
Externí odkaz:
https://doaj.org/article/d4e4c88c37a44790a5dddd3323669e36
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0185085 (2017)
To maintain optimal fitness, a cell must balance the risk of inadequate energy reserve for response to a potentially fatal perturbation against the long-term cost of maintaining high concentrations of ATP to meet occasional spikes in demand. Here we
Externí odkaz:
https://doaj.org/article/2006b1f2bb4540e08987d3056d8a55b2
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0163220 (2016)
We assessed the effects of red imported fire ants (Solenopsis invicta; hereafter fire ant) on the foraging of hispid cotton rats (Sigmodon hispidus). We used a manipulative experiment, placing resource patches with a known amount of millet seed withi
Externí odkaz:
https://doaj.org/article/4355dffac82e4fc98748db0a4419347c
Autor:
Anna M Czupryna, Joel S Brown, Machunde A Bigambo, Christopher J Whelan, Supriya D Mehta, Rachel M Santymire, Felix J Lankester, Lisa J Faust
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0167092 (2016)
Free-roaming dogs (Canis lupus familiaris) are of public health and conservation concern because of their potential to transmit diseases, such as rabies, to both people and wildlife. Understanding domestic dog population dynamics and how they could p
Externí odkaz:
https://doaj.org/article/f4c953ed7623437ba6b66c65f3a1e3e5
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88773 (2014)
We develop a decision tree based game-theoretical approach for constructing functional responses in multi-prey/multi-patch environments and for finding the corresponding optimal foraging strategies. Decision trees provide a way to describe details of
Externí odkaz:
https://doaj.org/article/e54d5cdb525e46c2aaf3a96dc0ec0caf
Publikováno v:
Frontiers in Oncology, Vol 3 (2013)
We apply competition colonization tradeoff models to tumor growth and invasion dynamics to explore the hypothesis that varying selection forces will result in predictable phenotypic differences in cells at the tumor invasive front compared to those i
Externí odkaz:
https://doaj.org/article/58ad2f02e3574e30a0a8b24aaf8e11e1
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63761 (2013)
Darwinian selection should preclude cooperation from evolving; yet cooperation is widespread among organisms. We show how kin selection and reciprocal altruism can promote cooperation in diverse 2×2 matrix games (prisoner's dilemma, snowdrift, and h
Externí odkaz:
https://doaj.org/article/345fdbd5341f49da937edd433e1588f7