Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Joel Rubin"'
Autor:
Sari Nusseibeh, Joel Rubin, Richard J. Schmierer, Dan Arbell, Bassima Alghussein, Omar Rahman
Publikováno v:
Middle East Policy. 28:3-21
Autor:
Joel Rubin
Publikováno v:
Reporting the Post-Communist Revolution ISBN: 9781351307369
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72c03b6c4a520bb6d9227363bd632d50
https://doi.org/10.4324/9781351307369-10
https://doi.org/10.4324/9781351307369-10
Autor:
Richard Frenette, Jocelyne Guay, Christine Brideau, Evelyn Martins, Marc Gagnon, Denis Riendeau, Joseph A. Mancini, Andre Giroux, Bernard Cote, Louise Boulet, David Claveau, Diane Ethier, Frédéric Massé, Richard Friesen, Daigen Xu, Anh Chau, Nathalie Méthot, Joel Rubin, Yves Ducharme, Hongping Yu, Sébastien Guiral
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5837-5841
Phenanthrene imidazoles 26 and 44 have been identified as novel potent, selective and orally active mPGES-1 inhibitors. These inhibitors are significantly more potent than the previously reported chlorophenanthrene imidazole 1 (MF63) with a human who
Autor:
Daniel, Guay, Christian, Beaulieu, Jean-Francois, Truchon, T, Jagadeeswar Reddy, Robert, Zamboni, Christopher I, Bayly, Nathalie, Methot, Joel, Rubin, Diane, Ethier, M, David Percival
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5392-5396
A series of dipeptide nitriles with a thienyl alanine in P2 were identified as potent and selective cathepsin C inhibitors. Incorporation of a substituted cyclopropyl moiety in P1 effectively protects these derivatives against hydrolase activity in w
Autor:
M. David Percival, Denis Normandin, Karen Ortega, Joel Rubin, Nathalie Méthot, Diane Ethier, T. Jagadeeswar Reddy, Denis Riendeau, Simon Wong, Daniel Guay, Christian Beaulieu
Publikováno v:
Molecular Pharmacology. 73:1857-1865
Inhibition of cathepsin C, a dipeptidyl peptidase that activates many serine proteases, represents an attractive therapeutic strategy for inflammatory diseases with a high neutrophil burden. We recently showed the feasibility of blocking the activati
Autor:
Joel Rubin, Erich L. Grimm, Joseph A. Mancini, Richard Friesen, Diane Ethier, Denis Riendeau, Nathalie Méthot, Renee Aspiotis, Jocelyne Guay, Helene Juteau, Sébastien Guiral, Yves Gareau
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:3352-3355
A series of potent and selective inhibitors of the inducible microsomal PGE2 synthase (mPGES-1) has been developed based on the indole FLAP inhibitor MK-886. Compounds 23 and 30 inhibit mPGES-1 with potencies in the low nanomolar range and with selec
Autor:
Diane Ethier, Denis Riendeau, Daigen Xu, Christine Brideau, Louise Boulet, Hongping Yu, Sébastien Guiral, Andre Giroux, David Claveau, Frédéric Massé, Richard Friesen, Jean-François Chiasson, Joseph A. Mancini, Anh Chau, Nathalie Méthot, Joel Rubin, Yves Ducharme, Patrick Roy, Bernard Cote, Jocelyne Guay
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(5)
A novel series of trisubstituted ureas has been identified as potent and selective mPGES-1 inhibitors. These compounds are selective over other prostanoid enzymes such as PGF synthase and TX synthase. This series of inhibitors was developed by lead o
Autor:
David Claveau, Nathalie Méthot, Jocelyne Guay, Joel Rubin, Yves Ducharme, Denis Riendeau, Hongping Yu, Sébastien Guiral, Andre Giroux, Joseph A. Mancini, Diane Ethier, Richard Frenette, Evelyn Martins, Louise Boulet, Christine Brideau, Daigen Xu, Frédéric Massé, Richard Friesen, Marc Gagnon, Bernard Cote
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(24)
Phenanthrene imidazole 3 (MF63) has been identified as a novel potent, selective, and orally active mPGES-1 inhibitor. This new series was developed by lead optimization of a hit from an internal HTS campaign. Compound 3 is significantly more potent
Autor:
Daniel Guay, Christian Beaulieu, Jean-Francois Truchon, T. Jagadeeswar Reddy, Christopher I. Bayly, Robert Zamboni, Nathalie Methot, Joel Rubin, Diane Ethier, M. David Percival
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:1463