Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Joel R. Walker"'
Autor:
Christoph Grohmann, Charlene M. Magtoto, Joel R. Walker, Ngee Kiat Chua, Anna Gabrielyan, Mary Hall, Simon A. Cobbold, Stephen Mieruszynski, Martin Brzozowski, Daniel S. Simpson, Hao Dong, Bridget Dorizzi, Annette V. Jacobsen, Emma Morrish, Natasha Silke, James M. Murphy, Joan K. Heath, Andrea Testa, Chiara Maniaci, Alessio Ciulli, Guillaume Lessene, John Silke, Rebecca Feltham
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
tag-Targeted Protein Degrader (tTPD) systems are powerful tools for preclinical target validation. Here the authors extend the tTPD platform by developing NanoTACs that degrade NanoLuc tagged substrates and benchmark each tTPD system using an interch
Externí odkaz:
https://doaj.org/article/cbe3c5d3eff94f2bbdf917175c5d3791
Autor:
Gloria I. Perez, David Broadbent, Ahmed A. Zarea, Benedikt Dolgikh, Matthew P. Bernard, Alicia Withrow, Amelia McGill, Victoria Toomajian, Lukose K. Thampy, Jack Harkema, Joel R. Walker, Thomas A. Kirkland, Michael H. Bachmann, Jens Schmidt, Masamitsu Kanada
Publikováno v:
Advanced Genetics, Vol 3, Iss 1, Pp n/a-n/a (2022)
Abstract Cancer cells produce heterogeneous extracellular vesicles (EVs) as mediators of intercellular communication. This study focuses on a novel method to image EV subtypes and their biodistribution in vivo. A red‐shifted bioluminescence resonan
Externí odkaz:
https://doaj.org/article/815d5e51afbb41bdac0ccb970b00d3f4
Autor:
Lian He, Zixian Huang, Kai Huang, Rui Chen, Nhung T. Nguyen, Rui Wang, Xiaoli Cai, Zhiquan Huang, Stefan Siwko, Joel R. Walker, Gang Han, Yubin Zhou, Ji Jing
Publikováno v:
Advanced Science, Vol 8, Iss 13, Pp n/a-n/a (2021)
Abstract Herein, a set of optogenetic tools (designated LiPOP) that enable photoswitchable necroptosis and pyroptosis in live cells with varying kinetics, is introduced. The LiPOP tools allow reconstruction of the key molecular steps involved in thes
Externí odkaz:
https://doaj.org/article/fda298d73bd24b9eb493f4f19064baa0
Autor:
Mariano Carossino, Devin Kenney, Aoife K. O’Connell, Paige Montanaro, Anna E. Tseng, Hans P. Gertje, Kyle A. Grosz, Maria Ericsson, Bertrand R. Huber, Susanna A. Kurnick, Saravanan Subramaniam, Thomas A. Kirkland, Joel R. Walker, Kevin P. Francis, Alexander D. Klose, Neal Paragas, Markus Bosmann, Mohsan Saeed, Udeni B. R. Balasuriya, Florian Douam, Nicholas A. Crossland
Publikováno v:
Viruses, Vol 14, Iss 3, p 535 (2022)
Animal models recapitulating COVID-19 are critical to enhance our understanding of SARS-CoV-2 pathogenesis. Intranasally inoculated transgenic mice expressing human angiotensin-converting enzyme 2 under the cytokeratin 18 promoter (K18-hACE2) represe
Externí odkaz:
https://doaj.org/article/f6b43f0802ad4855911f2d783877a9ee
Autor:
Natasa Gaspar, Giorgia Zambito, Iris J. C. Dautzenberg, Steve J. Cramer, Rob C. Hoeben, Clemens Lowik, Joel R. Walker, Thomas A. Kirkland, Thomas P. Smith, Wytske M. van Weerden, Jeroen de Vrij, Laura Mezzanotte
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 16, p 5863 (2020)
Reporter genes are used to visualize intracellular biological phenomena, including viral infection. Here we demonstrate bioluminescent imaging of viral infection using the NanoBiT system in combination with intraperitoneal injection of a furimazine a
Externí odkaz:
https://doaj.org/article/a094f2f1af234f1b938fbba57308621f
Autor:
Yichi Su, Joel R. Walker, Mary P. Hall, Mark A. Klein, Xiang Wu, Lance P. Encell, Kerriann M. Casey, Lan Xiang Liu, Guosong Hong, Michael Z. Lin, Thomas A. Kirkland
Publikováno v:
Nature Chemical Biology.
Bioluminescence imaging (BLI) allows non-invasive visualization of cells and biochemical events in vivo and thus has become an indispensable technique in biomedical research. However, BLI in the central nervous system remains challenging because luci
Autor:
Yan Wu, Joel R. Walker, Michael Westberg, Lin Ning, Michelle Monje, Thomas A. Kirkland, Michael Z. Lin, Yichi Su
Aberrant kinase activity contributes to the pathogenesis of brain cancers, neurodegeneration, and neuropsychiatric diseases, but identifying kinase inhibitors that function in the brain is challenging. Drug levels in blood do not predict efficacy in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dd566f99bf85c4eb7a188fdb202ff45
https://doi.org/10.1101/2022.12.30.522361
https://doi.org/10.1101/2022.12.30.522361
Autor:
Gloria I. Perez, David Broadbent, Ahmed A. Zarea, Benedikt Dolgikh, Matthew P. Bernard, Alicia Withrow, Amelia McGill, Victoria Toomajian, Lukose K. Thampy, Jack Harkema, Joel R. Walker, Thomas A. Kirkland, Michael H. Bachmann, Jens Schmidt, Masamitsu Kanada
Publikováno v:
Advanced genetics (Hoboken, N.J.). 3(1)
Cancer cells produce heterogeneous extracellular vesicles (EVs) as mediators of intercellular communication. This study focuses on a novel method to image EV subtypes and their biodistribution in vivo. A red-shifted bioluminescence resonance energy t
Autor:
Mary P. Hall, Mark A. Kay, Yunhee Park, Joel R. Walker, Lan Xiang Liu, Louai Labanieh, Robbie G. Majzner, Namdoo Kim, Michael Z. Lin, Lance P. Encell, Jennifer R. Cochran, Kerriann M. Casey, David C. Wang, Robin Hurst, Yichi Su, Thomas A. Kirkland, Feijie Zhang, Crystal L. Mackall, Thomas P. Smith
Publikováno v:
Nature Methods. 17:852-860
Sensitive detection of two biological events in vivo has long been a goal in bioluminescence imaging. Antares, a fusion of the luciferase NanoLuc to the orange fluorescent protein CyOFP, has emerged as a bright bioluminescent reporter with orthogonal
Autor:
Jens C. Schmidt, Alicia Withrow, Joel R. Walker, Michael Bachmann, Benedikt Dolgikh, Victoria Toomajian, Gloria I. Perez, Lukose K. Thampy, Thormas A. Kirkland, Jack R. Harkema, Amelia McGill, Masamitsu Kanada, Ahmed A. Zarea, Matthew P. Bernard, David Broadbent
Cancer cells produce heterogeneous extracellular vesicles (EVs) as mediators of intercellular communication. Our study focused on a novel method to image EV subtypes and their biodistribution in vivo. Regardless of injection routes, we established th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94f1f6c5bfdca11291085faa3ed69813
https://doi.org/10.1101/2021.07.23.453512
https://doi.org/10.1101/2021.07.23.453512