Výsledky vyhledávání - "Joel R. Morgan"

Reversible Metal-Dependent Destabilization and Stabilization of a Stem-Chelate-Loop Probe Binding to an Unmodified DNA Target

Autor: David V. X. Nguyen, John A. Zebala, Sara R. Rybka, Angela R. Frohman, Joel R. Morgan

Publikováno v: Bioconjugate Chemistry. 23:2020-2024

Herein, we report the discovery of a novel DNA probe with a stem-chelate-loop structure, wherein the stability of the probe-target duplex can be modulated lower or higher using a narrow concentration range of dilute transition metal ions (0.1-10 μM)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b6ff61423cc0845dd6906efc5b7f247
https://doi.org/10.1021/bc3003293

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Intestinal Transport of Aminopterin Enantiomers in Dogs and Humans with Psoriasis Is Stereoselective: Evidence for a Mechanism Involving the Proton-Coupled Folate Transporter

Autor: Joel R. Morgan, Lei Wang, Aleem Gangjee, Stuart J. Kahn, Aaron D. Schuler, Breck Thrash, Dean Y. Maeda, Larry H. Matherly, Alan Menter, Christina Cherian, John A. Zebala

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 342:696-708

N-[4-[[(2,4-diamino-6-pterdinyl)methyl]amino]benzoyl]-l/d-glutamic acid (l/d-AMT) is an investigational drug in phase 1 clinical development that consists of the l-and d-enantiomers of aminopterin (AMT). l/d-AMT is obtained from a novel process for m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e631960def7924fbacc3f7353fb09d9b
https://doi.org/10.1124/jpet.112.195479

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Synthesis of carbohydrate-linked poly(polyoxometalate) poly(amido)amine dendrimers

Autor: Joel R. Morgan, Mary J. Cloninger

Publikováno v: Journal of Polymer Science Part A: Polymer Chemistry. 43:3059-3066

Mannose-functionalized and ethoxyethanol-functionalized poly(amido)amine dendrimers bound multiple vanadate-substituted polyoxotungstate Wells–Dawson-type polyoxometalates (POMs). Dendrimers incorporating 10–30 POMs were characterized with NMR, t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f16f66cf21d17025f70ea457dae58d5b
https://doi.org/10.1002/pola.20799

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Clusters of ligands on dendrimer surfaces

Autor: Kristian H. Schlick, Julianna J Weiel, Joel R. Morgan, Mary J. Cloninger, Melissa S. Kelsey

The development of methodology that is designed to allow a significant increase in the patterning and in the functionalization of the dendrimer is the ultimate goal of the research described here. Glycoside clusters based on TRIS were formed using cl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5c7327c1d102945648e9aaf9dd9ff9a
https://europepmc.org/articles/PMC3156387/

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Synthesis and Evaluation of Phosphopeptides Containing Iminodiacetate Groups as Binding Ligands of the Src SH2 Domain

Autor: Kezhen Huang, Aaron D. Schuler, Absar Faruqui, Yousef Ahmadibeni, Joel R. Morgan, Gongqin Sun, Guofeng Ye, Keykavous Parang, John A. Zebala

Phosphopeptide pTyr-Glu-Glu-Ile (pYEEI) has been introduced as an optimal Src SH2 domain ligand. Peptides, Ac-K(IDA)pYEEIEK(IDA) (1), Ac-KpYEEIEK (2), Ac-K(IDA)pYEEIEK (3), and Ac-KpYEEIEK(IDA) (4), containing 0-2 iminodiacetate (IDA) groups at the N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d6a027cb680b89f5317562c6bf735d5
https://europepmc.org/articles/PMC2754053/

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Snap-to-it probes: chelate-constrained nucleobase oligomers with enhanced binding specificity

Autor: Robert P. Lyon, Joel R. Morgan, John A. Zebala, Dean Y. Maeda

Publikováno v: Nucleic Acids Research

We describe snap-to-it probes, a novel probe technology to enhance the hybridization specificity of natural and unnatural nucleic acid oligomers using a simple and readily introduced structural motif. Snap-to-it probes were prepared from peptide nucl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72c661691d012f6106ea1d9bfb4772f7
https://pubmed.ncbi.nlm.nih.gov/18448470

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Altering the strength of lectin binding interactions and controlling the amount of lectin clustering using mannose/hydroxyl-functionalized dendrimers

Autor: Eric K. Woller, Eric D. Walter, Mary J. Cloninger, David J. Singel, Joel R. Morgan

Publikováno v: Journal of the American Chemical Society. 125(29)

Protein-carbohydrate interactions play a critical role in many biological recognition events. Multivalent therapeutic agents that utilize protein-carbohydrate interactions have proven difficult to design, primarily because the fundamental requirement

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::987f29a1a11cfde29bdad302e95d4406
https://pubmed.ncbi.nlm.nih.gov/12862477

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Heterogeneously functionalized dendrimers

Autor: Joel R, Morgan, Mary J, Cloninger

Publikováno v: Current opinion in drug discoverydevelopment. 5(6)

Significant timely advances have been made in the synthesis of heterogeneously functionalized dendrimers. Convergent, divergent and other functionalization techniques have been used to create a variety of complex dendrimer motifs with more than one t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::469cb66253752cbbda678b0af501bf4c
https://pubmed.ncbi.nlm.nih.gov/12478727

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