Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Joel R. Meyerson"'
Autor:
Purushotham Selvakumar, Ana I. Fernández-Mariño, Nandish Khanra, Changhao He, Alice J. Paquette, Bing Wang, Ruiqi Huang, Vaughn V. Smider, William J. Rice, Kenton J. Swartz, Joel R. Meyerson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
The Kv1.3 potassium channel is expressed abundantly on activated T cells and mediates the cellular immune responses. Here, the authors report structures of the Kv1.3 potassium channel with and without immunoglobulin modulators, shedding light on the
Externí odkaz:
https://doaj.org/article/d07ce3fe1deb42c097bcb4bfddf1e075
Autor:
Changhao He, Jorge Mansilla-Soto, Nandish Khanra, Mohamad Hamieh, Victor Bustos, Alice J. Paquette, Andreina Garcia Angus, Derek M. Shore, William J. Rice, George Khelashvili, Michel Sadelain, Joel R. Meyerson
Publikováno v:
Sci Immunol
Chimeric antigen receptor (CAR) T cell therapy relies on T cells that are guided by synthetic receptors to target and lyse cancer cells. CARs bind to cell surface antigens through an scFv (binder), the affinity of which is central to determining CAR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9aef7f4096276919b5ed5d64647e300
https://europepmc.org/articles/PMC10228544/
https://europepmc.org/articles/PMC10228544/
Autor:
Joel R. Meyerson, Richard K Hite, Edward T. Eng, Jian-Shu Lou, Jianyun Huang, Kelsey D. Jordan, Xin-Yun Huang, Minfei Su, Kamela O. Alegre, Navid Paknejad
Publikováno v:
Nat Struct Mol Biol
The β1-adrenergic receptor (β1-AR) can activate two families of G proteins. When coupled to Gs, β1-AR increases cardiac output, and coupling to Gi leads to decreased responsiveness in myocardial infarction. By comparative structural analysis of tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbbaffe1f5d6ad2bd526fed3095666b2
https://doi.org/10.1038/s41594-021-00679-2
https://doi.org/10.1038/s41594-021-00679-2
Autor:
Purushotham Selvakumar, Ana I. Fernández-Mariño, Bing Wang, William J. Rice, Joel R. Meyerson, Kenton J. Swartz
Publikováno v:
Biophysical Journal. 122:13a-14a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::653a77f47367b34d122e5ab739344687
https://doi.org/10.1016/j.bpj.2022.11.301
https://doi.org/10.1016/j.bpj.2022.11.301
Therapeutic antibody activation of the glucocorticoid-induced TNF receptor by a clustering mechanism
Autor:
Changhao He, Rachana R. Maniyar, Yahel Avraham, Roberta Zappasodi, Radda Rusinova, Walter Newman, Heidi Heath, Jedd D. Wolchok, Rony Dahan, Taha Merghoub, Joel R. Meyerson
Publikováno v:
Science advances. 8(8)
GITR is a TNF receptor, and its activation promotes immune responses and drives antitumor activity. The receptor is activated by the GITR ligand (GITRL), which is believed to cluster receptors into a high-order array. Immunotherapeutic agonist antibo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f17065f4fa228d5379e28910ccb5cb4
https://pubmed.ncbi.nlm.nih.gov/35213218
https://pubmed.ncbi.nlm.nih.gov/35213218
Publikováno v:
The Journal of general physiology. 154(10)
The epithelial Na+ channel (ENaC) is a heterotrimeric protein whose assembly, trafficking, and function are highly regulated. To better understand the biogenesis and activation of the channel, we quantified the expression of individual subunits of EN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adbdf2e1945099c854a1617237763c6d
https://pubmed.ncbi.nlm.nih.gov/35939271
https://pubmed.ncbi.nlm.nih.gov/35939271
Publikováno v:
Molecular Systems Biology, Vol 5, Iss 1, Pp 1-8 (2009)
Abstract This report provides a global view of how gene expression is affected by DNA replication. We analyzed synchronized cultures of Saccharomyces cerevisiae under conditions that prevent DNA replication initiation without delaying cell cycle prog
Externí odkaz:
https://doaj.org/article/d2cd4856c7454d93aa455a9e115e43f7
Graphene Oxide-Supported Microwell Grids for Preparing Cryo-EM Samples with Controlled Ice Thickness
Autor:
Ji Yeon Shim, Sung Mi Lee, Won Chul Lee, Jungwon Park, Minyoung Lee, Ohkyung Kwon, Min Kyung Ahn, Min Ho Kang, Byung Hyo Kim, S. K. Kang, Joel R. Meyerson, Min Jae Lee, Sungho Jeon, Junsun Park, Jee Young Lee, Kwang Il Lim, Tae Jin Jeon, Soung Hun Roh
Publikováno v:
Advanced materials (Deerfield Beach, Fla.). 33(43)
Cryogenic-electron microscopy (cryo-EM) is the preferred method to determine 3D structures of proteins and to study diverse material systems that intrinsically have radiation or air sensitivity. Current cryo-EM sample preparation methods provide limi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa429e9f51fe162e90ad39b99bc4f074
https://pubmed.ncbi.nlm.nih.gov/34510585
https://pubmed.ncbi.nlm.nih.gov/34510585
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
Kainate receptors (KARs) are L-glutamate-gated ion channels that regulate synaptic transmission and modulate neuronal circuits. KARs have strict assembly rules and primarily function as heteromeric receptors in the brain. A longstanding question is h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f5fd81dc883276ed8e6bad7f5f1c15a
https://doi.org/10.7554/elife.66097
https://doi.org/10.7554/elife.66097