Výsledky vyhledávání - "Joel R. Calvin"

Akademický článek

The History of Flow Chemistry at Eli Lilly and Company

Autor: Martin D. Johnson, Timothy Braden, Joel R. Calvin, Alison Campbell Brewer, Kevin P. Cole, Scott Frank, Mark Kerr, Doug Kjell, Michael E. Kopach, Joseph R. Martinelli, Scott. A. May, Juan Rincon, Timothy D. White, Matthew H. Yates

Publikováno v: CHIMIA, Vol 77, Iss 5 (2023)

Flow chemistry was initially used for speed to early phase material delivery in the development laboratories, scaling up chemical transformations that we would not or could not scale up batch for safety reasons. Some early examples included a Newman

Externí odkaz: https://doaj.org/article/b4057d6508d9480596cdbdfe9135202f

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Scalable Synthesis of Enantiopure Bis-3,4-diazaphospholane Ligands for Asymmetric Catalysis

Autor: Clark R. Landis, Joel R. Calvin, Alison N. Campbell, Scott A. May, Joseph R. Martinelli, M. Leigh Abrams, Bradley Jones

Publikováno v: The Journal of Organic Chemistry. 81:11965-11970

An optimized route to enantiopure tetra-carboxylic acid and tetra-carboxamide bis(diazaphospholane) ligands that obviates chromatographic purification is presented. This synthesis, which is demonstrated on 15 and 100 g scales, features a scalable cla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39fb477853d571a8d8ea39822739f1e9
https://doi.org/10.1021/acs.joc.6b01915

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Continuous Liquid Vapor Reactions Part 2: Asymmetric Hydroformylation with Rhodium-Bisdiazaphos Catalysts in a Vertical Pipes-in-Series Reactor

Autor: Gordon R. Lambertus, Adam D. McFarland, Joel R. Calvin, M. Leigh Abrams, Joseph R. Martinelli, James R. Stout, Martin D. Johnson, Jonas Y. Buser, Clark R. Landis, Bradley Jones, Scott A. May

Publikováno v: Organic Process Research & Development. 20:901-910

Asymmetric hydroformylation (AHF) of 2-vinyl-6-methoxynaphthalene demonstrates important design characteristics of a vertical pipes-in-series plug flow reactor (PFR). The regio- and enantioselectivity of the AHF reaction provide a chemical probe of g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9adde49948e5a01c8b0b2453ff731d40
https://doi.org/10.1021/acs.oprd.5b00406

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Continuous Liquid Vapor Reactions Part 1: Design and Characterization of a Reactor for Asymmetric Hydroformylation

Autor: Clark R. Landis, Martin D. Johnson, M. Leigh Abrams, Scott A. May, James R. Stout, Joel R. Calvin, Bradley Jones, Prashant B. Kokitkar, Gordon R. Lambertus

Publikováno v: Organic Process Research & Development. 20:888-900

A research scale continuous reactor system was designed and developed for high pressure asymmetric hydroformylation (AHF) reactions with an 8 h reaction time. The continuous reactor achieved high kLa, low axial dispersion, and an 8 mL liquid holdup v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0cd39c223a5f6ee47f7694703e32dbe6
https://doi.org/10.1021/acs.oprd.5b00407

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Development of an NH4Cl-Catalyzed Ethoxy Ethyl Deprotection in Flow for the Synthesis of Merestinib

Autor: Michael O. Frederick, Kurt T. Lorenz, Michael E. LeTourneau, Martin D. Johnson, Richard D. Miller, Lauren E. Cziesla, Todd D. Maloney, Richard F. Cope, Joel R. Calvin, Yangwei John Pu

Publikováno v: Organic Process Research & Development. 19:1411-1417

An NH4Cl-catalyzed ethoxy ethyl deprotection was developed for the synthesis of merestinib, a MET inhibitor. Alternative reactor technologies using temperatures above the solvent boiling point are combined with this mild catalyst to promote the depro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac1dc935d59b7fb2aaa26b52859fce73
https://doi.org/10.1021/acs.oprd.5b00240

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Development and Scale-Up of a Continuous, High-Pressure, Asymmetric Hydrogenation Reaction, Workup, and Isolation

Autor: Wei-Ming Sun, Joel R. Calvin, Jacob R. Remacle, Brian D. Haeberle, Scott A. May, Nikolay Zaborenko, Martin D. Johnson, John Brennan, William D. Diseroad, Michael Miller, James R. Stout

Publikováno v: Organic Process Research & Development. 16:1017-1038

A fully continuous process including an asymmetric hydrogenation reaction operating at 70 bar hydrogen, aqueous extraction, and crystallization was designed, developed, and demonstrated at pilot scale. This paper highlights safety, quality, and throu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::305c007f32a2f6b59f0689bd127961a1
https://doi.org/10.1021/op200362h

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Rapid Development and Scale-Up of a 1H-4-Substituted Imidazole Intermediate Enabled by Chemistry in Continuous Plug Flow Reactors

Autor: Hannah Yu, Rachel N. Richey, Brian D. Haeberle, Edward Francis Plocharczyk, Schmid Christopher Randall, Amy Rebecca Jines, Scott A. May, Joel R. Calvin, Gregory A. Rener, Martin D. Johnson, Radhe K. Vaid, Richard D. Miller, Timothy M. Braden

Publikováno v: Organic Process Research & Development. 16:982-1002

The development of reactions in a continuous fashion in plug flow tube reactors (PFR) offers unique advantages to the drug development and scale-up process and can also enable chemistry that would be difficult to perform via batch processing. Herein,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9660768bfe748ef94c04edb7defc73f2
https://doi.org/10.1021/op200351g

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