Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Joel R, Gever"'
Autor:
Rachel A. Matt, Frederick G. Westhorpe, Rosemary F. Romuar, Payal Rana, Joel R. Gever, Anthony P. Ford
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Noradrenergic projections from the brainstem locus coeruleus drive arousal, attentiveness, mood, and memory, but specific adrenoceptor (AR) function across the varied brain cell types has not been extensively characterized, especially with agonists.
Externí odkaz:
https://doaj.org/article/34a4c0f376f345a38da1a4da5f3b6f14
Publikováno v:
Autonomic neuroscience : basicclinical. 235
Gefapixant is the approved generic name for a compound also known as MK-7264, and prior to that AF-219 and RO-4926219. It is the first-in-class clinically developed antagonist for the P2X3 subtype of trimeric ionotropic purinergic receptors, a family
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1e9408547f2851f3147246f17f06a78
https://pubmed.ncbi.nlm.nih.gov/34403981
https://pubmed.ncbi.nlm.nih.gov/34403981
Autor:
Julian F. R. Paton, Helio Cesar Salgado, Anthony P.D.W. Ford, Pedro Lourenço Katayama, Joel R Gever, Ana Paula Abdala, Ian Charles, Wioletta Pijacka
Publikováno v:
Respir Physiol Neurobiol
Hyperreflexia of the peripheral chemoreceptors is a potential contributor of apnoeas of prematurity (AoP). Recently, it was shown that elevated P2X3 receptor expression was associated with elevated carotid body afferent sensitivity. Therefore, we tes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e714d2df7c4da29248334afa5618824
https://pubmed.ncbi.nlm.nih.gov/32259688
https://pubmed.ncbi.nlm.nih.gov/32259688
Publikováno v:
Br J Pharmacol
Background & Purpose The P2X3 receptor is an ATP‐gated ion channel expressed by sensory afferent neurons, and is as a target to treat chronic sensitisation conditions. The first‐in‐class, selective P2X3 and P2X2/3 receptor antagonist, the diami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6a7c5826fa0308e02438d2bc283b8e8
https://doi.org/10.1111/bph.14677
https://doi.org/10.1111/bph.14677
Autor:
Joel R. Gever, Matthew P. Jacobson, Kartika Widjaja, Satish Rao, Adam R. Renslo, Sina Ghaemmaghami, Stanley B. Prusiner, John J. Irwin, B. Michael Silber, Zhe Li, Alejandra Gallardo-Godoy
Publikováno v:
Bioorganic & Medicinal Chemistry. 21:7999-8012
During prion diseases, a normally benign, host protein, denoted PrPC, undergoes alternative folding into the aberrant isoform, PrPSc. We used ELISA assays to identify and confirm hits in order to develop leads that reduce PrPSc in prion-infected divi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6353c6d30fcbf676bd07b8d3f4d9c35d
https://doi.org/10.1016/j.bmc.2013.09.022
https://doi.org/10.1016/j.bmc.2013.09.022
Autor:
Joel R. Gever, Steven Ferrara, Henry Roehl, Edward J. Cochrane, Jennifer C. Louth, Matthew P. Jackson, B. Michael Silber, Sarah Baxendale, Beining Chen, Fiona J. Sorrell, Mark J. Thompson
Publikováno v:
European Journal of Medicinal Chemistry. 46:4125-4132
A series of highly potent indole-3-glyoxylamide based antiprion agents was previously characterized, focusing on optimization of structure-activity relationship (SAR) at positions 1-3 of the indole system. New libraries interrogating the SAR at indol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbdca545244382b2e5d887e2155bdf2f
https://doi.org/10.1016/j.ejmech.2011.06.013
https://doi.org/10.1016/j.ejmech.2011.06.013
Autor:
David H Hackos, Anthony P.D.W. Ford, Werner Rubas, Rothschild Soto, Marcos E. Milla, Robert Henningsen, Geoffrey Burnstock, Joel R Gever, Michael Patrick Dillon, Renee Sharon Martin, Sandip Panicker, Ian B Oglesby
Publikováno v:
British Journal of Pharmacology. 160:1387-1398
Background and purpose: Purinoceptors containing the P2X3 subunit (P2X3 homotrimeric and P2X2/3 heterotrimeric) are members of the P2X family of ion channels gated by ATP and may participate in primary afferent sensitization in a variety of pain-rela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::345ce3dda68cb13c3421e6ad219ac75b
https://doi.org/10.1111/j.1476-5381.2010.00796.x
https://doi.org/10.1111/j.1476-5381.2010.00796.x
Autor:
Anthony P.D.W. Ford, Joel R Gever, Muzaffar Alam, Alam Jahangir, Jeff Zira, David S. Carter, Clara Jeou Jen Lin, Daisy Joe Du Bois, Paul J. Wagner, Michael Patrick Dillon, Yansheng Zhai
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:1632-1635
The purinoceptor subtypes P2X(3) and P2X(2/3) have been shown to play a pivotal role in models of various pain conditions. Identification of a potent and selective dual P2X(3)/P2X(2/3) diaminopyrimidine antagonist RO-4 prompted subsequent optimizatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cf811936e1f98876523ee9b5ab12638
https://doi.org/10.1016/j.bmcl.2009.01.097
https://doi.org/10.1016/j.bmcl.2009.01.097
Autor:
Bikramjit Chopra, Jonathan M. Beckel, Ann T. Hanna-Mitchell, Stacey Barrick, Joel R Gever, Lori A. Birder, Anthony P.D.W. Ford
Publikováno v:
American Journal of Physiology-Renal Physiology. 294:F821-F829
The control and regulation of the lower urinary tract are partly mediated by purinergic signaling. This study investigated the distribution and function of P2Y receptors in the rat urinary bladder. Application of P2Y agonists to rat urothelial cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86293bdadb46d179316392bfa0a3abf1
https://doi.org/10.1152/ajprenal.00321.2006
https://doi.org/10.1152/ajprenal.00321.2006
Autor:
Joel R Gever, Michael Patrick Dillon, Geoffrey Burnstock, Anthony P.D.W. Ford, Debra A. Cockayne
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 452:513-537
Significant progress in understanding the pharmacological characteristics and physiological importance of homomeric and heteromeric P2X channels has been achieved in recent years. P2X channels, gated by ATP and most likely trimerically assembled from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a06d2017e4da9b77609bc4215d79921
https://doi.org/10.1007/s00424-006-0070-9
https://doi.org/10.1007/s00424-006-0070-9