Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Joel O. Melby"'
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
The ability to quickly and easily assess the activity of large collections of enzymes for a desired substrate holds great promise in the field of biocatalysis. Cell-free synthesis, although not practically amenable for large-scale enzyme production,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf39bc903c5562be68512e1d80488088
https://doi.org/10.1038/s41598-020-67307-9
https://doi.org/10.1038/s41598-020-67307-9
Autor:
James R. Doroghazi, Joel O. Melby, Courtney L. Cox, Jonathan I. Tietz, Karol Sokolowski, Douglas A. Mitchell
Publikováno v:
ACS Chemical Biology
Natural products remain an important source of drug candidates, but the difficulties inherent to traditional isolation, coupled with unacceptably high rates of compound rediscovery, limit the pace of natural product detection. Here we describe a reac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbccf07124549a6bcd85f1084582b3ed
http://europepmc.org/articles/PMC4168802
http://europepmc.org/articles/PMC4168802
Publikováno v:
Biochemistry. 53:413-422
Thiazole/oxazole-modified microcins (TOMMs) comprise a structurally diverse family of natural products with varied bioactivities linked by the presence of posttranslationally installed thiazol(in)e and oxazol(in)e heterocycles. The detailed investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::093917b1898ba7487d0a807daf9d6e47
https://doi.org/10.1021/bi401529y
https://doi.org/10.1021/bi401529y
Autor:
Yue Hao, Brandon J. Burkhart, Douglas A. Mitchell, Joel O. Melby, Patricia M. Blair, Vinayak Agarwal, Satish K. Nair, Jaeheon Lee
Publikováno v:
Proceedings of the National Academy of Sciences. 110:12954-12959
Plantazolicin (PZN), a polyheterocyclic, N α ,N α -dimethylarginine–containing antibiotic, harbors remarkably specific bactericidal activity toward strains of Bacillus anthracis , the causative agent of anthrax. Previous studies demonstrated that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44a5ff4a372e521632589217325f718b
https://doi.org/10.1073/pnas.1306101110
https://doi.org/10.1073/pnas.1306101110
Publikováno v:
Nature chemical biology
Thiazole/oxazole-modified microcins (TOMMs) encompass a recently defined class of ribosomally synthesized natural products with a diverse set of biological activities. Although TOMM biosynthesis has been investigated for over a decade, the mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed7e146632839d3c8644f680dff7ed95
https://doi.org/10.1038/nchembio.944
https://doi.org/10.1038/nchembio.944
Autor:
Stefanie B. Bumpus, Katie J. Molohon, Bradley S. Evans, Jaeheon Lee, Joel O. Melby, Douglas A. Mitchell, Neil L. Kelleher, Kyle L. Dunbar
Publikováno v:
ACS Chemical Biology. 6:1307-1313
The soil-dwelling, plant growth-promoting bacterium Bacillus amyloliquefaciens FZB42 is a prolific producer of complex natural products. Recently, a new FZB42 metabolite, plantazolicin (PZN), has been described as a member of the growing thiazole/oxa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37c891d434e99e388a8d95dbbf7bfee3
https://doi.org/10.1021/cb200339d
https://doi.org/10.1021/cb200339d
Publikováno v:
Current Opinion in Chemical Biology. 15:369-378
With billions of years of evolution under its belt, Nature has been expanding and optimizing its biosynthetic capabilities. Chemically complex secondary metabolites continue to challenge and inspire today’s most talented synthetic chemists. A brief
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b45075433ecb8a39aa4a7dcd61afa7d5
https://doi.org/10.1016/j.cbpa.2011.02.027
https://doi.org/10.1016/j.cbpa.2011.02.027
Publikováno v:
ACS chemical biology. 8(9)
Plantazolicin (PZN) is a polyheterocyclic natural product derived from a ribosomal peptide that harbors remarkable antibiotic selectivity for the causative agent of anthrax, Bacillus anthracis. To simultaneously establish the structure-activity relat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e574678ba1ff096942a300ca97fc1948
https://pubmed.ncbi.nlm.nih.gov/23823732
https://pubmed.ncbi.nlm.nih.gov/23823732
Autor:
Stefanie B. Bumpus, Jaeheon Lee, Neil L. Kelleher, Joel O Melby, Kyle L Dunbar, Douglas A. Mitchell, Katie J. Molohon, Bradley S Evans
Publikováno v:
The FASEB Journal. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5188ed2fba185e823aee36e6bfdc2370
https://doi.org/10.1096/fasebj.26.1_supplement.552.1
https://doi.org/10.1096/fasebj.26.1_supplement.552.1
Publikováno v:
Journal of the American Chemical Society. 134(11)
The thiazole/oxazole-modified microcins (TOMMs) represent a burgeoning class of ribosomal natural products decorated with thiazoles and (methyl)oxazoles originating from cysteines, serines and threonines. The ribosomal nature of TOMMs allows for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::953254d0e4eedd42e60d65d0be90cec5
https://pubmed.ncbi.nlm.nih.gov/22401305
https://pubmed.ncbi.nlm.nih.gov/22401305