Zobrazeno 1 - 10
of 327
pro vyhledávání: '"Joel M. Reid"'
Autor:
Shefali Chauhan, Emily Lian, Iman Habib, Qianqian Liu, Nicole M. Anders, Megan M. Bugg, Noah C. Federman, Joel M. Reid, Clinton F. Stewart, Tristan Cates, Joel E. Michalek, Charles Keller
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Rhabdomyosarcoma (RMS) is the most common childhood soft tissue sarcoma. For the alveolar subtype (ARMS), the presence of the PAX3::FOXO1 fusion gene and/or metastases are strong predictors of poor outcome. Metastatic PAX3::FOXO1 + ARMS ofte
Externí odkaz:
https://doaj.org/article/f0d777b3277b40b58dcedcf300719a97
Autor:
Andrea Stojakovic, Sergey Trushin, Anthony Sheu, Layla Khalili, Su-Youne Chang, Xing Li, Trace Christensen, Jeffrey L. Salisbury, Rachel E. Geroux, Benjamin Gateno, Padraig J. Flannery, Mrunal Dehankar, Cory C. Funk, Jordan Wilkins, Anna Stepanova, Tara O’Hagan, Alexander Galkin, Jarred Nesbitt, Xiujuan Zhu, Utkarsh Tripathi, Slobodan Macura, Tamar Tchkonia, Tamar Pirtskhalava, James L. Kirkland, Rachel A. Kudgus, Renee A. Schoon, Joel M. Reid, Yu Yamazaki, Takahisa Kanekiyo, Song Zhang, Emirhan Nemutlu, Petras Dzeja, Adam Jaspersen, Ye In Christopher Kwon, Michael K. Lee, Eugenia Trushina
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-9 (2024)
Externí odkaz:
https://doaj.org/article/67f438cf2e6642df8392e5f12d364395
Autor:
Erin M. Guest, John A. Kairalla, Meenakshi Devidas, Emily Hibbitts, Andrew J. Carroll, Nyla A. Heerema, Holly R. Kubaney, Margaret A. August, Sidharth Ramesh, Byunggil Yoo, Midhat S. Farooqi, Melinda G. Pauly, Daniel S. Wechsler, Rodney R. Miles, Joel M. Reid, Cynthia D. Kihei, Lia Gore, Elizabeth A. Raetz, Stephen P. Hunger, Mignon L. Loh, Patrick A. Brown
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
Infants less than 1 year old diagnosed with KMT2A-rearranged (KMT2A-r) acute lymphoblastic leukemia (ALL) are at high risk of remission failure, relapse, and death due to leukemia, despite intensive therapies. Infant KMT2A-r ALL blasts are characteri
Externí odkaz:
https://doaj.org/article/b91198f427bc4dd39ad94aff06c2ddf3
Autor:
Swaathi Jayaraman, Xinyan Wu, Krishna R. Kalari, Xiaojia Tang, Mary J. Kuffel, Elizabeth S. Bruinsma, Shahrzad Jalali, Kevin L. Peterson, Cristina Correia, Rachel A. Kudgus, Scott H. Kaufmann, Santosh Renuse, James N. Ingle, Joel M. Reid, Matthew M. Ames, Alan P. Fields, Matthew J. Schellenberg, John R. Hawse, Akhilesh Pandey, Matthew P. Goetz
Publikováno v:
npj Breast Cancer, Vol 9, Iss 1, Pp 1-16 (2023)
Abstract Endoxifen, a secondary tamoxifen metabolite, is a potent antiestrogen exhibiting estrogen receptor alpha (ERα) binding at nanomolar concentrations. Phase I/II clinical trials identified clinical activity of Z-endoxifen (ENDX), in endocrine-
Externí odkaz:
https://doaj.org/article/809fda6ff0ea4cad83dc611d55814884
Autor:
Aref Al‐Kali, Ibrahim Aldoss, Pamela J. Atherton, Carrie A. Strand, Bijal Shah, Jonathan Webster, Bhavana Bhatnagar, Karen S. Flatten, Kevin L. Peterson, Paula A. Schneider, Sarah A. Buhrow, Jianping Kong, Joel M. Reid, Alex A. Adjei, Scott H. Kaufmann
Publikováno v:
Cancer Medicine, Vol 12, Iss 23, Pp 21229-21239 (2023)
Abstract Background Despite recent approval of several new agents, relapsed acute lymphoblastic leukemia (ALL) remains challenging to treat. Sapanisertib (MLN0128/TAK‐228) is an oral TORC1/2 inhibitor that exhibited preclinical activity against ALL
Externí odkaz:
https://doaj.org/article/55ca42b54be149f0b8acb389ece68dc9
Autor:
Jin-Ah Kim, Kenneth A. Crawford, Piero A. Spada, Leah R. Martin, Jiaqi Zhang, Rain Wong, Joel M. Reid, Clinton F. Stewart, Timothy M. Frank, Qianqian Liu, Joel E. Michalek, Charles Keller
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Ewing sarcoma (EWS) is a malignant tumor arising in bone or soft tissue that occurs in adolescent and young adult patients as well as adults later in life. Although non-metastatic EWS is typically responsive to treatment when newly diagnosed
Externí odkaz:
https://doaj.org/article/e3bdb641aa15428894c65e7b7a142c51
Autor:
Peter N. Morcos, Jan Schlender, Rolf Burghaus, Jonathan Moss, Adam Lloyd, Barrett H. Childs, Margaret E. Macy, Joel M. Reid, John Chung, Dirk Garmann
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 7, Pp 1197-1209 (2023)
Abstract Copanlisib is an intravenously administered phosphatidylinositol 3‐kinase (PI3K) inhibitor which was investigated in pediatric patients with relapsed/refractory solid tumors. A model‐informed approach was undertaken to support and confir
Externí odkaz:
https://doaj.org/article/8b78db85f6ae49dda69722b29cc9fdde
Autor:
Filip Janku, Grace M. Choong, Mateusz Opyrchal, Afshin Dowlati, Cinta Hierro, Jordi Rodon, Andreas Wicki, Martin D. Forster, Sarah P. Blagden, Jun Yin, Joel M. Reid, Helene Muller, Natasa Cmiljanovic, Vladimir Cmiljanovic, Alex A. Adjei
Publikováno v:
Cancers, Vol 16, Iss 6, p 1137 (2024)
Background: Bimiralisib is a pan-PI3K/mTOR inhibitor demonstrating antitumor efficacy in preclinical models. The objectives of this study were to identify a maximum tolerated dose (MTD), pharmacokinetics (PK), a dosing schedule, and adverse events (A
Externí odkaz:
https://doaj.org/article/dc11e6bb219149eea8c74e000a1fc021
Autor:
Faizal Z. Asumda, Nellie A. Campbell, Mohamed A. Hassan, Reza Fathi, Daniella F. Vasquez Rico, Melanie Kiem, Ethan V. Vang, Yo Han Kim, Xin Luo, Daniel R. O’Brien, Sarah A. Buhrow, Joel M. Reid, Michael J. Moore, Vered Katz Ben-Yair, Mark L. Levitt, Jennifer L. Leiting, Amro M. Abdelrahman, Xinli Zhu, Fabrice Lucien, Mark J. Truty, Lewis R. Roberts
Publikováno v:
Cancers, Vol 16, Iss 5, p 1050 (2024)
Upamostat is an orally available small-molecule serine protease inhibitor that is a highly potent inhibitor of trypsin 1, trypsin 2, trypsin 3 (PRSS1/2/3), and the urokinase-type plasminogen activator (uPA). These enzymes are expressed in many cancer
Externí odkaz:
https://doaj.org/article/b28f6e53a90c47cf8ff9a1d3118f22b6
Autor:
Jason N. Barreto, Joel M. Reid, Carrie A. Thompson, Kristin C. Mara, Andrew D. Rule, Kianoush B. Kashani, Nelson Leung, Thomas R. Larson, Renee M. McGovern, Thomas E. Witzig, Erin F. Barreto
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 1, Pp 105-117 (2022)
Abstract High‐dose methotrexate (HDMTX) pharmacokinetics (PKs), including the best estimated glomerular filtration rate (eGFR) equation that reflects methotrexate (MTX) clearance, requires investigation. This prospective, observational, single‐ce
Externí odkaz:
https://doaj.org/article/fd48e7349bac405b95e18b046ac1b12d