A molecular method for the delivery of small molecules and proteins across the cell wall of algae using molecular transporters

Autor: Joel M. Hyman, Paul A. Wender, Brian M. Trantow, Erika I. Geihe, Bahram Parvin

Publikováno v: Proceedings of the National Academy of Sciences. 109:13225-13230

Interest in algae has significantly accelerated with the increasing recognition of their potentially unique role in medical, materials, energy, bioremediation, and synthetic biological research. However, the introduction of tools to study, control, o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0fa68da54f41e478ccfc5f182463055
https://doi.org/10.1073/pnas.1202509109

Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade

Autor: Vivi M. Heine, Ari J. Firestone, Kyuho Han, Yun Zhao, Joel M. Hyman, David H. Rowitch, Mark Sun, Cory A. Ocasio, David E. Solow-Cordero, Surajit Sinha, Jin Jiang, James K. Chen, Jason Wu, Paul G. Rack

Publikováno v: Hyman, J M, Firestone, A J, Heine, V M, Zhao, Y, Ocasio, C A, Han, K, Sun, M, Rack, P G, Sinha, S, Wu, J J, Solow-Cordero, D E, Jiang, J, Rowitch, D H & Chen, J K 2009, ' Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade ', Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 33, pp. 14132-7 . https://doi.org/10.1073/pnas.0907134106
Proceedings of the National Academy of Sciences of the United States of America, 106(33), 14132-7. National Academy of Sciences

Inappropriate activation of the Hedgehog (Hh) signaling pathway has been implicated in a diverse spectrum of cancers, and its pharmacological blockade has emerged as an anti-tumor strategy. While nearly all known Hh pathway antagonists target the tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c63e9aed28fa2e01e73922269bb19e29
https://doi.org/10.1073/pnas.0907134106

The Imidazopyridine Derivative JK184 Reveals Dual Roles for Microtubules in Hedgehog Signaling

Autor: Surajit Sinha, Joel M. Hyman, Ari J. Firestone, James K. Chen, Kyuho Han, Cory A. Ocasio, Paul G. Rack, Tommaso Cupido

Publikováno v: Angewandte Chemie International Edition. 48:2321-2324

Eradicating hedgehogs: The title molecule has been previously identified as a potent inhibitor of the Hedgehog signaling pathway, which gives embryonic cells information needed to develop properly. This molecule is shown to modulate Hedgehog target g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74d0a60c440abee5171e22fb75e21f98
https://doi.org/10.1002/anie.200805666

Identification of fluorescent compounds with non-specific binding property via high throughput live cell microscopy

Autor: Joel M. Hyman, Ju Han, Hang Chang, Virginia A. Spencer, Young-Tae Chang, Gerald V. Fontenay, Bahram Parvin, Sangeeta Nath, Charles T. Anderson, Marit Nilsen-Hamilton, Kai Zhang

Publikováno v: PLoS ONE, Vol 7, Iss 1, p e28802 (2012)
PLoS ONE

Introduction Compounds exhibiting low non-specific intracellular binding or non-stickiness are concomitant with rapid clearing and in high demand for live-cell imaging assays because they allow for intracellular receptor localization with a high sign

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ef285038658c9d459b04641d6469c39
http://europepmc.org/articles/PMC3252290?pdf=render

The ENTH domain

Autor: Joel M. Hyman, Hong Chen, Pietro De Camilli, Ezequiel Panepucci, Axel T. Brunger, Alex Bateman

Publikováno v: FEBS Letters. (1):11-18

The epsin NH2-terminal homology (ENTH) domain is a membrane interacting module composed by a superhelix of α-helices. It is present at the NH2-terminus of proteins that often contain consensus sequences for binding to clathrin coat components and th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::024aa91c387438ddbe8bc5cc681b6263