Výsledky vyhledávání - "Joel M. Esken"

Conformational Studies of N3-Substituted [1,3,4]-Oxadiazinan-2-ones

Autor: Christopher D. Maroules, Jennifer R. Blackburn, Joel M. Esken, Gregory M. Ferrence, Tana Brady, Shawn R. Hitchcock, Jean M. Standard, David M. Casper

Publikováno v: The Journal of Organic Chemistry. 67:8871-8876

Pseudoephedrine-based [1,3,4]-oxadiazinan-2-ones acylated at the N(3)-position with either acetyl (2a), propionyl (2b), or phenylacetyl (2c) substituents are known to undergo conformational changes that are observable by (13)C NMR spectroscopy. The c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71494fd456b60e149c3e71bbc9a32bae
https://doi.org/10.1021/jo020322g

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Toward the Development of a Structurally Novel Class of Chiral Auxiliaries: Diastereoselective Aldol Reactions of a (1R,2S)-Ephedrine-Based 3,4,5,6-Tetrahydro-2H-1,3,4-oxadiazin-2-one

Autor: James R. Burgeson, Joel M. Esken, Shawn R. Hitchcock, David M. Casper, Gregory M. Ferrence

Publikováno v: Organic Letters. 4:3739-3742

[reaction: see text] Asymmetric aldol addition reactions have been conducted with (1R,2S)-ephedrine-derived 3,4,5,6-tetrahydro-2H-1,3,4-oxadiazin-2-one (2). Diastereoselectivities range from 75:25 to 99:1 for the formation of the crude non-Evans syn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::264d4c9eaab3fa20c1eee6942f6d7875
https://doi.org/10.1021/ol026721f

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A novel 2:1 cycloadduct of dimethyl acetylenedicarboxylate with 3,5-diphenyl-4-methoximino-4H-pyrazole 1,2-dioxide

Autor: Kalyan Nagulapalli, Gregory M. Ferrence, Joel M. Esken, Andre L. Kilpatrick, John F. Hansen

Publikováno v: Tetrahedron Letters. 44:3789-3791

Two equivalents of dimethyl acetylenedicarboxylate react with 3,5-diphenyl-4-methoximino-4H-pyrazole 1,2-dioxide in acetonitrile under reflux. The major product was shown by X-ray analysis to be a 5,8-epoxyisoxazolo[2,3-d]-[1,4]-diazepine derivative.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::51589ecde80551f226561f02178fe189
https://doi.org/10.1016/s0040-4039(03)00781-0

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(5S,6R)-4,5-Dimethyl-6-phenyl-3-trimethylacetyl-2H-1,3,4-oxadiazinan-2-one

Autor: Gregory M. Ferrence, Jennifer R. Blackburn, Joel M. Esken, Shawn R. Hitchcock

Publikováno v: Acta Crystallographica Section E Structure Reports Online. 59:o212-o214

The crystal structure of the title compound, C16H22N2O3, was undertaken in the course of a study on an acylated pseudoephedrine-derived 1,3,4-oxadiazinan-2-one. The conformation adopted by this heterocycle is a contorted half-chair, in which the im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7cda5e930744035408d1250f80b3569d
https://doi.org/10.1107/s1600536803001314

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Intramolecular chiral relay at stereogenic nitrogen. Synthesis and application of a new chiral auxiliary derived from (1R,2S)-norephedrine and acetone

Autor: Jeremy F. Vaughn, David M. Casper, Jennifer M. Finefield, Gregory M. Ferrence, Shawn R. Hitchcock, Joel M. Esken

Publikováno v: The Journal of organic chemistry. 69(3)

(1R,2S)-Norephedrine has been employed in the synthesis of a novel 3,4,5,6-tetrahydro-2H-1,3,4-oxadiazin-2-one via reductive alkylation with acetone, N-nitrosation, reduction, and cyclization. The oxadiazinone was treated with either propionyl chlori

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d50123163ef0a3b9add95ae22a6a799c
https://pubmed.ncbi.nlm.nih.gov/14750795

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