Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Joel M Kralj"'
Autor:
Giancarlo Noe Bruni, Joel M Kralj
Publikováno v:
eLife, Vol 9 (2020)
Aminoglycosides are broad-spectrum antibiotics whose mechanism of action is under debate. It is widely accepted that membrane voltage potentiates aminoglycoside activity, which is ascribed to voltage-dependent drug uptake. In this paper, we measured
Externí odkaz:
https://doaj.org/article/7a50f159ebcc44b2ae731255743bd766
Autor:
Christopher A Werley, Miao-Ping Chien, Jellert Gaublomme, Karthik Shekhar, Vincent Butty, B Alexander Yi, Joel M Kralj, William Bloxham, Laurie A Boyer, Aviv Regev, Adam E Cohen
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0172671 (2017)
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) are a promising platform for cardiac studies in vitro, and possibly for tissue repair in humans. However, hiPSC-CM cells tend to retain morphology, metabolism, patterns of gene exp
Externí odkaz:
https://doaj.org/article/23e59abed85b48d2860c1c438a159503
Publikováno v:
Frontiers in Physiology, Vol 5 (2014)
The cardiac action potential (AP) and the consequent cytosolic Ca2+ transient are key indicators of cardiac function. Natural developmental processes, as well as many drugs and pathologies change the waveform, propagation, or variability (between cel
Externí odkaz:
https://doaj.org/article/148ca242c81c42489afcf0c7f1e98c1f
Autor:
Jeehae Park, Christopher A Werley, Veena Venkatachalam, Joel M Kralj, Sulayman D Dib-Hajj, Stephen G Waxman, Adam E Cohen
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e85221 (2013)
Development of improved fluorescent voltage indicators is a key challenge in neuroscience, but progress has been hampered by the low throughput of patch-clamp characterization. We introduce a line of non-fluorescent HEK cells that stably express NaV
Externí odkaz:
https://doaj.org/article/b36bdf06c1f44ba09bf334ed1edcc186
Publikováno v:
Microorganisms, Vol 9, Iss 5, p 1000 (2021)
Changes in bacterial physiology necessarily precede cell death in response to antibiotics. Herein we investigate the early disruption of Ca2+ homeostasis as a marker for antibiotic response. Using a machine learning framework, we quantify the tempora
Externí odkaz:
https://doaj.org/article/32c04de1f79a4d6594a9443c9ecff866
Autor:
Christian T. Meyer, Grace K. Lynch, Dana F. Stamo, Eugene J. Miller, Anushree Chatterjee, Joel M. Kralj
Counting viable cells is a universal practice in microbiology. The colony forming unit (CFU) assay has remained the gold standard to measure viability across disciplines; however, it is time-intensive and resource-consuming. Herein, we describe the G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41051d7b1f452dd29dd704d85e43a579
https://doi.org/10.1101/2023.01.04.522767
https://doi.org/10.1101/2023.01.04.522767
Autor:
Joel M. Kralj
Publikováno v:
Bioelectricity
It began, as with many good things, at a happy hour. Adam Cohen, a young assistant professor asked whether rhodopsins could be used to optically sense voltage. In the heady days of 2009, channel rhodopsin had just been unveiled as a voltage actuator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::512b17154bc27eb5b42e49a9bdd44898
https://doi.org/10.1089/bioe.2021.0017
https://doi.org/10.1089/bioe.2021.0017
1.AbstractBacterial evolution of antibiotic resistance is facilitated by non-genetic resistance that increases drug tolerance, buying time for evolutionary innovation. Escherichia coli treated with aminoglycosides permanently lose the ability to divi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5d7ca833b354c7b2caaddd6474526a0
https://doi.org/10.1101/2021.10.04.463054
https://doi.org/10.1101/2021.10.04.463054
Publikováno v:
Microorganisms, Vol 9, Iss 1000, p 1000 (2021)
Microorganisms
Volume 9
Issue 5
Microorganisms
Volume 9
Issue 5
Changes in bacterial physiology necessarily precede cell death in response to antibiotics. Herein we investigate the early disruption of Ca2+ homeostasis as a marker for antibiotic response. Using a machine learning framework, we quantify the tempora
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfb195672902cebdceeb8a1b02395131
https://www.mdpi.com/2076-2607/9/5/1000
https://www.mdpi.com/2076-2607/9/5/1000
Autor:
Joel M. Kralj, Christian T. Meyer
During the SARS-COV2 pandemic, there has been a persistent call for universal testing to better inform policy decisions. However, a little considered aspect of this call is the relationship between a test's accuracy and the tested demographic. What a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4300081c1626c09849cae371cf11da2
https://doi.org/10.1101/2021.04.23.21255984
https://doi.org/10.1101/2021.04.23.21255984