Zobrazeno 1 - 10 of 108 pro vyhledávání: '"Joel M, Harp"'
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Akademický článek
Computational redesign of a fluorogen activating protein with Rosetta
Autor: Nina G. Bozhanova, Joel M. Harp, Brian J. Bender, Alexey S. Gavrikov, Dmitry A. Gorbachev, Mikhail S. Baranov, Christina B. Mercado, Xuan Zhang, Konstantin A. Lukyanov, Alexander S. Mishin, Jens Meiler
Publikováno v: PLoS Computational Biology, Vol 17, Iss 11 (2021)
The use of unnatural fluorogenic molecules widely expands the pallet of available genetically encoded fluorescent imaging tools through the design of fluorogen activating proteins (FAPs). While there is already a handful of such probes available, eac
Externí odkaz: https://doaj.org/article/826bc1b7f0f148b8ad96f37c2d2ca4db
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2
Base excision repair of the N-(2-deoxy-d-erythro-pentofuranosyl)-urea lesion by the hNEIL1 glycosylase
Autor: Rachana Tomar, Irina G Minko, Pankaj Sharma, Andrew H Kellum, Li Lei, Joel M Harp, T M Iverson, R Stephen Lloyd, Martin Egli, Michael P Stone
Publikováno v: Nucleic Acids Research. 51:3754-3769
The N-(2-deoxy-d-erythro-pentofuranosyl)-urea DNA lesion forms following hydrolytic fragmentation of cis-5R,6S- and trans-5R,6R-dihydroxy-5,6-dihydrothymidine (thymine glycol, Tg) or from oxidation of 7,8-dihydro-8-oxo-deoxyguanosine (8-oxodG) and su
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bdb5f1f87aea913de54b53daf99c3e04
https://doi.org/10.1093/nar/gkad164
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4
Water structure around a left-handed Z-DNA fragment analyzed by cryo neutron crystallography
Autor: Leighton Coates, Brendan Sullivan, Martin Egli, Joel M. Harp
Publikováno v: Nucleic Acids Research
Even in high-quality X-ray crystal structures of oligonucleotides determined at a resolution of 1 Å or higher, the orientations of first-shell water molecules remain unclear. We used cryo neutron crystallography to gain insight into the H-bonding pa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a927827d4e41f49ba867f7fc7df8629f
http://europepmc.org/articles/PMC8096259
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5
Cryo neutron crystallography demonstrates influence of RNA 2'-OH orientation on conformation, sugar pucker and water structure
Autor: Joel M Harp, Terry P Lybrand, Pradeep S Pallan, Leighton Coates, Brendan Sullivan, Martin Egli
Publikováno v: Nucleic acids research. 50(13)
The ribose 2′-hydroxyl is the key chemical difference between RNA and DNA and primary source of their divergent structural and functional characteristics. Macromolecular X-ray diffraction experiments typically do not reveal the positions of hydroge
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc8117926f4e294ab0402fd67e28ab8f
https://pubmed.ncbi.nlm.nih.gov/35819202
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6
First crystal structure of a non-canonical amino acid linked to a paramagnetic lanthanide tag facilitates protein structure determination using NMR-derived restraints
Autor: Elleansar Okwei, Soumya Ganguly, Heather L. Darling, Joel M. Harp, Alican Gulsevin, Irene Coin, Hassane Mchaourab, Kaitlyn Ledwitch, Georg Kuenze, Jens Meiler
SummarySite-directed spin labeling of proteins via non-canonical amino acids (ncAAs) is a non-traditional method for the measurement of pseudocontact shifts (PCSs) by nuclear magnetic resonance (NMR) spectroscopy. PCSs provide long-range distance and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f24646cb04b230ce4548251d5163b1ec
https://doi.org/10.1101/2022.04.10.487812
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8
RNAs Containing Carbocyclic Ribonucleotides
Autor: Masaaki Akabane-Nakata, Tyler Chickering, Joel M. Harp, Mark K. Schlegel, Shigeo Matsuda, Martin Egli, Muthiah Manoharan
Publikováno v: Organic letters. 24(2)
Toward the goal of evaluation of carbocyclic ribonucleoside-containing oligonucleotide therapeutics, we developed convenient, scalable syntheses of all four carbocyclic ribonucleotide phosphoramidites and the uridine solid-support building block. Cry
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7224b3cd2ffab7054edf980dcba25e88
https://pubmed.ncbi.nlm.nih.gov/34958225
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9
Computational redesign of a fluorogen activating protein with Rosetta
Autor: Jens Meiler, Konstantin A. Lukyanov, Mikhail S. Baranov, Nina G. Bozhanova, Christina B. Mercado, Brian J. Bender, Dmitry A. Gorbachev, Xuan Zhang, Alexey S. Gavrikov, Alexander S. Mishin, Joel M. Harp
Publikováno v: PLoS Computational Biology
PLoS Computational Biology, Vol 17, Iss 11, p e1009555 (2021)
PLoS Computational Biology, Vol 17, Iss 11 (2021)
The use of unnatural fluorogenic molecules widely expands the pallet of available genetically encoded fluorescent imaging tools through the design of fluorogen activating proteins (FAPs). While there is already a handful of such probes available, eac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b31c58ce78fbf10509c5d88969b32b3
http://europepmc.org/articles/PMC8601599
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10
Overcoming GNA/RNA base-pairing limitations using isonucleotides improves the pharmacodynamic activity of ESC+ GalNAc-siRNAs
Autor: John Szeto, Adam Castoreno, Muthiah Manoharan, Daniel Berman, Sally Schofield, Klaus Charisse, Christopher R. Brown, Shigeo Matsuda, Joel M. Harp, Mark K Schlegel, Joseph D. Barry, Martin Maier, Martin Egli
Publikováno v: Nucleic Acids Research
We recently reported that RNAi-mediated off-target effects are important drivers of the hepatotoxicity observed for a subset of GalNAc–siRNA conjugates in rodents, and that these findings could be mitigated by seed-pairing destabilization using a s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::885a1db2fe18159e67d5d52b2f7a9193
https://pubmed.ncbi.nlm.nih.gov/34648028
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