Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Joel Leong"'
Publikováno v:
Malaria Journal, Vol 17, Iss 1, Pp 1-11 (2018)
Abstract Background KAF156 is a novel imidazolopiperazine anti-malarial with activity against pre-erythrocytic liver stages, asexual and sexual blood stages. Based on in vitro data, a two-way pharmacokinetic interaction was hypothesized for KAF156 us
Externí odkaz:
https://doaj.org/article/85c32f821eb644bd81783a0789e93e01
Publikováno v:
ACS Infectious Diseases. 2:530-537
The apicomplexan parasite Cryptosporidium is the second most important diarrheal pathogen causing life-threatening diarrhea in children, which is also associated with long-term growth faltering and cognitive deficiency. Cryptosporidiosis is a parasit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb175edb63ef853a72fc377e15ba16f5
https://doi.org/10.1021/acsinfecdis.6b00094
https://doi.org/10.1021/acsinfecdis.6b00094
Autor:
Lan Chen, Jagannath Kota, Vishal Koradia, Gangadhar Sunkara, Marie-Christine Wolf, Sampath Kalluri, F. Joel Leong, Daniel S. Stein, Jay Prakash Jain
Publikováno v:
Antimicrobial Agents and Chemotherapy
The artemether-lumefantrine combination requires food intake for the optimal absorption of lumefantrine. In an attempt to enhance the bioavailability of lumefantrine, new solid dispersion formulations (SDF) were developed, and the pharmacokinetics of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0425d79536cf95188522f8943f10fca0
https://pubmed.ncbi.nlm.nih.gov/28630183
https://pubmed.ncbi.nlm.nih.gov/28630183
Autor:
Thierry T. Diagana, Suresh B. Lakshminarayana, Susan Noh, Francesca Blasco, Carrie F. Brooks, Jennifer A. Zambriski, Laura B. Goodman, Gu Feng, Sumiti Vinayak, Gillian T. Herbert, Peter Gedeck, Lijun Zhang, Jayesh Tandel, Siau H. Lim, Christian G. Noble, F. Joel Leong, Alex Chao, Juergen Wagner, Bin Zou, Boris Striepen, Tracy Sy, Ravinder Reddy Kondreddi, Christophe Bodenreider, Ujjini H. Manjunatha, Ghislain M. C. Bonamy, Adam Sateriale
Publikováno v:
Nature
Diarrhoeal disease is responsible for 8.6% of global child mortality. Recent epidemiological studies found the protozoan parasite Cryptosporidium to be a leading cause of paediatric diarrhoea, with particularly grave impact on infants and immunocompr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2401d87bda2ac82100ab6adc7648cf7
https://pubmed.ncbi.nlm.nih.gov/28757629
https://pubmed.ncbi.nlm.nih.gov/28757629
Autor:
Kittiphum Chuthasmit, Ming S. Cheung, François Nosten, Nicholas J. White, F. Joel Leong, Daniela Wieser, Baldur Magnusson, Peter Pertel, Tran T. Duong, Thierry T. Diagana, Aung Pyae Phyo, Rong Zhao, Marc Sultan, Chirapong Uthaisin, Yiyan Feng, Borimas Hanboonkunupakarn, Sasithon Pukrittayakamee, Podjanee Jittamala, Ruobing Li, Xiaolei Xun
KAF156 belongs to a new class of antimalarial agents (imidazolopiperazines), with activity against asexual and sexual blood stages and the preerythrocytic liver stages of malarial parasites.We conducted a phase 2, open-label, two-part study at five c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::530cf19aa6ba4d8c13d934418725a18f
https://doi.org/10.1056/nejmoa1602250
https://doi.org/10.1056/nejmoa1602250
Publikováno v:
A Color Atlas of Comparative Pathology of Pulmonary Tuberculosis
Drug Discovery for Neglected Diseases of the Developing World, P. Herrling Background The Drug Discovery Process Therapeutic Tools Drug Discovery Phases Phase I-Phase IIa Phase IIb-Phase III References Tuberculosis Biology and Drug Discovery, T. Dick
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72709334311ebd7fa82da4053d09e12c
https://doi.org/10.1201/ebk1439835272
https://doi.org/10.1201/ebk1439835272
Autor:
Gilbert Lefèvre, Thierry T. Diagana, Baldur Magnusson, Joel Leong, Ruobing Li, Jay Prakash Jain, Peter Pertel
Publikováno v:
Malaria Journal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::173742f36c7b1e3808a8d65a5322844c
https://doi.org/10.1186/1475-2875-13-s1-o37
https://doi.org/10.1186/1475-2875-13-s1-o37
Publikováno v:
Antimicrobial Agents and Chemotherapy
KAF156 belongs to a new class of antimalarial, the imidazolopiperazines, and is currently in clinical development for the treatment of uncomplicated malaria. This first-in-human, single- and multiple-ascending-dose study in 70 healthy male volunteers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1bf748a4a2fecfd1e571d7f82dcd1fc
https://pubmed.ncbi.nlm.nih.gov/25136017
https://pubmed.ncbi.nlm.nih.gov/25136017
An annual death toll of 2 million, coupled with rising drug resistance, highlights the need for the development of new drugs, better diagnostics, and a tuberculosis (TB) vaccine. Addressing these key issues, A Color Atlas of Comparative Pathology of
Publikováno v:
Antiparasitic and Antibacterial Drug Discovery: From Molecular Targets to Drug Candidates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3590003d97e92f5abcf5491786abcccc
https://doi.org/10.1002/9783527626816.ch21
https://doi.org/10.1002/9783527626816.ch21