Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Joel Kawakami"'
Autor:
Weitao Pan, Dan Sherman, Raphael Rios, Sang-phyo Hong, Farah Dhun, Matthew A. J. Duncton, Marc Labelle, Hai-Ying He, Mélissa Arbour, Yong-Jiang Xu, Hu Liu, Joel Kawakami
Publikováno v:
Tetrahedron Letters. 48:8943-8946
Differential reactivity of the amine functionality in a number of common 1,2-diamine starting materials is exploited to undertake an expedient synthesis of unsymmetrical 2,3,6-trisubstituted quinoxaline and unsymmetrical 2,3,7-trisubstituted pyridopy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d9005c303036bb3c81fdb5ed334ad98
https://doi.org/10.1016/j.tetlet.2007.10.117
https://doi.org/10.1016/j.tetlet.2007.10.117
Autor:
Alexander S. Kiselyov, Jason Gerlak, Robin L. Rosler, Margarita Camara, James Fleming, Sui Ping Lee, Stan Mitelman, Asra Malikzay, Vatee Pattaropong, Ying Wang, Avdhoot Velankar, Evgueni L. Piatnitski, Leon M. Smith, Julia Winslow Lohman, Xiaoling Chen, Xiaohu Ouyang, David Surguladze, Joel Kawakami, M. Carolina Tuma, Marc Labelle, Jacqueline Doody, Hai-Ying He, Kai Zhou
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:1191-1196
Oxadiazole derivatives were synthesized and evaluated for their ability to inhibit tubulin polymerization and to cause mitotic arrest in tumor cells. The most potent compounds inhibited tubulin polymerization at concentrations below 1 microM. Lead an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87d09b776083064c4c4f8ef3c541b433
https://doi.org/10.1016/j.bmcl.2005.11.094
https://doi.org/10.1016/j.bmcl.2005.11.094
Autor:
Chris Balagtas, Yaron R. Hadari, Matthew A. J. Duncton, Stan Mitelman, Alexander S. Kiselyov, Dan Sherman, Leon M. Smith, Daniel L. Milligan, Paul Kussie, Wai C. Wong, Robin L. Rolster, Reeti Katoch-Rouse, David Surguladze, James R. Tonra, Joel Kawakami, Peter Bohlen, Sheetal Patel, Jacqueline Doody, Eugene L. Piatnitski Chekler, Ying Wang
Publikováno v:
Bioorganicmedicinal chemistry. 17(2)
A series of arylphthalazine derivatives were synthesized and evaluated as antagonists of VEGF receptor II (VEGFR-2). IM-094482 57, which was prepared in two steps from commercially available starting materials, was found to be a potent inhibitor of V
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dda1f6a22124c16fa6d6a6398b7c2d5b
https://pubmed.ncbi.nlm.nih.gov/19101155
https://pubmed.ncbi.nlm.nih.gov/19101155
Autor:
Daniel L. Milligan, Evgueni L. Piatnitski, Leon M. Smith, Reeti Katoch-Rouse, Matthew A. J. Duncton, Joel Kawakami, Jacqueline Doody, Alexander S. Kiselyov, Wai C. Wong, Chris Balagtas
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(6)
A novel class of 1-(isoquinolin-5-yl)-4-arylamino-phthalazines is described as inhibitors of vascular endothelial growth factor receptor II (VEGFR-2). Many compounds display VEGFR-2 inhibitory activity with an IC(50) as low as 0.017 microM in an HTRF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e0914d5a78a8a02c2e8fe66a632807f
https://pubmed.ncbi.nlm.nih.gov/16386418
https://pubmed.ncbi.nlm.nih.gov/16386418
Autor:
Alexander S. Kiselyov, Reeti Katoch-Rouse, Joel Kawakami, Matthew A. J. Duncton, Chris Balagtas, Dan Sherman, Daniel L. Miligan, Jacqueline Doody, Evgueni L. Piatnitski, Wai C. Wong
Publikováno v:
Bioorganicmedicinal chemistry letters. 15(21)
A novel class of 4-arylamino-phthalazin-1-yl-benzamides is described as inhibitors of vascular endothelial growth factor receptor II (VEGFR-2). Several compounds display potent VEGFR-2 inhibitory activity with an IC50 as low as 0.078 microM in an HTR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f28f1483533c1211394f1f456b242c78
https://pubmed.ncbi.nlm.nih.gov/16143524
https://pubmed.ncbi.nlm.nih.gov/16143524