Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Joel K. Annor-Gyamfi"'
Autor:
Frances M. Potjewyd, Joel K. Annor‐Gyamfi, Jeffrey Aubé, Shaoyou Chu, Ivie L. Conlon, Kevin J. Frankowski, Shiva K. R. Guduru, Brian P. Hardy, Megan D. Hopkins, Chizuru Kinoshita, Dmitri B. Kireev, Emily R. Mason, Charles T. Moerk, Felix Nwogbo, Kenneth H. Pearce Jr., Timothy I. Richardson, David A. Rogers, Disha M. Soni, Michael Stashko, Xiaodong Wang, Carrow Wells, Timothy M. Willson, Stephen V. Frye, Jessica E. Young, Alison D. Axtman
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 8, Iss 1, Pp n/a-n/a (2022)
Abstract Introduction A chemogenomic set of small molecules with annotated activities and implicated roles in Alzheimer's disease (AD) called the AD Informer Set was recently developed and made available to the AD research community: https://treatad.
Externí odkaz:
https://doaj.org/article/b33c64d9d5fa4d89ad4554a76c6b0930
Autor:
Frances M. Potjewyd, Joel K. Annor‐Gyamfi, Jeffrey Aubé, Shaoyou Chu, Ivie L. Conlon, Kevin J. Frankowski, Shiva K. R. Guduru, Brian P. Hardy, Megan D. Hopkins, Chizuru Kinoshita, Dmitri B. Kireev, Emily R. Mason, Charles T. Moerk, Felix Nwogbo, Kenneth H. Pearce, Timothy I. Richardson, David A. Rogers, Disha M. Soni, Michael Stashko, Xiaodong Wang, Carrow Wells, Timothy M. Willson, Stephen V. Frye, Jessica E. Young, Alison D. Axtman
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 8, Iss 1, Pp n/a-n/a (2022)
Abstract Introduction The portfolio of novel targets to treat Alzheimer's disease (AD) has been enriched by the Accelerating Medicines Partnership Program for Alzheimer's Disease (AMP AD) program. Methods Publicly available resources, such as literat
Externí odkaz:
https://doaj.org/article/e2d6a7a95cd548b0ab470f7102528da7
Publikováno v:
Molecules, Vol 26, Iss 4, p 890 (2021)
An efficient synthetic route to highly substituted dihydroquinolines and dihydronaphthyridines has been developed using a domino reaction of Morita-Baylis-Hillman (MBH) acetates with primary aliphatic and aromatic amines in DMF at 50–90 °C. The MB
Externí odkaz:
https://doaj.org/article/709ff66734a24349acad2239861e379c
Publikováno v:
Molecules, Vol 25, Iss 21, p 5168 (2020)
An efficient synthetic route to highly functionalized naphthalenes and quinolines has been developed using domino reactions between Morita–Baylis–Hillman (MBH) acetates and active methylene compounds (AMCs) promoted by anhydrous K2CO3 in dry N,N-
Externí odkaz:
https://doaj.org/article/0651300fc8904819ab19dd16338ecd07
Autor:
Joel K. Annor-Gyamfi, John M. Jarrett, Joseph O. Osazee, Dobrusia Bialonska, Crystal Whitted, Victoria E. Palau, Abbas G. Shilabin
Publikováno v:
Heliyon, Vol 4, Iss 2 (2018)
Cancer remains the second major cause of death in the world. Thus, there is a pressing need to identify potential synthetic route for the development of novel anticancer agents which will serve as lead compounds to effectively combat this life-threat
Externí odkaz:
https://doaj.org/article/e06166388e24400d86403813841495c4
4H-Benzo[d][1,3]oxazin-4-ones and Dihydro Analogs from Substituted Anthranilic Acids and Orthoesters
Autor:
Joel K. Annor-Gyamfi, Richard A. Bunce
Publikováno v:
Molecules, Vol 24, Iss 19, p 3555 (2019)
A one-pot route to 2-alkyl and 2-aryl-4H-benzo[d][1,3]oxazin-4-ones (also known as 4H-3,1-benzoxazin-4-ones) has been developed and studied. The method involves the reaction of aryl-substituted anthranilic acids with orthoesters in ethanol catalyzed
Externí odkaz:
https://doaj.org/article/3202c153648a456488719df153b0db17
Publikováno v:
Molecules, Vol 23, Iss 11, p 2925 (2018)
Quinazolin-4(3H)-ones have been prepared in one step from 2-aminobenzamides and orthoesters in the presence of acetic acid. Simple 2-aminobenzamides were easily converted to the heterocycles by refluxing in absolute ethanol with 1.5 equivalents of th
Externí odkaz:
https://doaj.org/article/3cdee7f608af4488aa931d190d88eb53
Publikováno v:
Molecules, Vol 23, Iss 3, p 674 (2018)
An efficient route to substituted 1-aryl-1H-indazoles has been developed and optimized. The method involved the preparation of arylhydrazones from acetophenone or benzaldehyde substituted by fluorine at C2 and nitro at C5, followed by deprotonation a
Externí odkaz:
https://doaj.org/article/05a9b027bc574b07a807c081a2974766
Autor:
Alison D. Axtman, David H. Drewry, Julie E. Pickett, Sebastian Mathea, Franziska Preuss, Carrow I. Wells, Joel K. Annor-Gyamfi, Verena Dederer
Publikováno v:
Journal of Medicinal Chemistry
The pyrimidine core has been utilized extensively to construct kinase inhibitors, including eight FDA-approved drugs. Because the pyrimidine hinge-binding motif is accommodated by many human kinases, kinome-wide selectivity of resultant molecules can
Autor:
Achala N D Punchi Hewage, Joel K. Annor-Gyamfi, Huili Yao, Kevin P. Battaile, Richard A. Bunce, Scott Lovell, Kevin Meraz, Anabel Soldano, Mario Rivera
Publikováno v:
ACS Infectious Diseases. 7:123-140
Bacteria depend on a well-regulated iron homeostasis to survive adverse environments. A key component of the iron homeostasis machinery is the compartmentalization of Fe3+ in bacterioferritin and its subsequent mobilization as Fe2+ to satisfy metabol