Zobrazeno 1 - 10
of 260
pro vyhledávání: '"Joel K Elmquist"'
Autor:
Alexandre Caron, Heather M Dungan Lemko, Carlos M Castorena, Teppei Fujikawa, Syann Lee, Caleb C Lord, Newaz Ahmed, Charlotte E Lee, William L Holland, Chen Liu, Joel K Elmquist
Publikováno v:
eLife, Vol 7 (2018)
Leptin is critical for energy balance, glucose homeostasis, and for metabolic and neuroendocrine adaptations to starvation. A prevalent model predicts that leptin’s actions are mediated through pro-opiomelanocortin (POMC) neurons that express lepti
Externí odkaz:
https://doaj.org/article/24478469d7784efb8a6ac25e389c9bb8
Autor:
Teppei Fujikawa, Carlos M Castorena, Mackenzie Pearson, Christine M Kusminski, Newaz Ahmed, Pavan K Battiprolu, Ki Woo Kim, Syann Lee, Joseph A Hill, Philipp E Scherer, William L Holland, Joel K Elmquist
Publikováno v:
eLife, Vol 5 (2016)
Exercise has numerous beneficial metabolic effects. The central nervous system (CNS) is critical for regulating energy balance and coordinating whole body metabolism. However, a role for the CNS in the regulation of metabolism in the context of the e
Externí odkaz:
https://doaj.org/article/6d58bf1dd8944b4c95eeb7c5c29d4ec8
Autor:
Virginie Mansuy-Aubert, Laurent Gautron, Syann Lee, Angie L Bookout, Christine M Kusminski, Kai Sun, Yuan Zhang, Philipp E Scherer, David J Mangelsdorf, Joel K Elmquist
Publikováno v:
eLife, Vol 4 (2015)
Peripheral neural sensory mechanisms play a crucial role in metabolic regulation but less is known about the mechanisms underlying vagal sensing itself. Recently, we identified an enrichment of liver X receptor alpha and beta (LXRα/β) in the nodose
Externí odkaz:
https://doaj.org/article/eb47156db2604f869ab1e9ff969d86a6
Autor:
Michael M Scott, Mario Perello, Jen-Chieh Chuang, Ichiro Sakata, Laurent Gautron, Charlotte E Lee, Danielle Lauzon, Joel K Elmquist, Jeffrey M Zigman
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e44089 (2012)
The neuronal coordination of metabolic homeostasis requires the integration of hormonal signals with multiple interrelated central neuronal circuits to produce appropriate levels of food intake, energy expenditure and fuel availability. Ghrelin, a pe
Externí odkaz:
https://doaj.org/article/a66bdc3ca5d547ff81ea4b1407087e14
Autor:
Simeng Wang, Qingzhang Zhu, Guosheng Liang, Tania Franks, Magalie Boucher, Kendra K. Bence, Mingjian Lu, Carlos M. Castorena, Shangang Zhao, Joel K. Elmquist, Philipp E. Scherer, Jay D. Horton
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 1 (2022)
Externí odkaz:
https://doaj.org/article/1fc7f4c2eea94465b405660a8d64e00f
Autor:
John R, Speakman, Joel K, Elmquist
Publikováno v:
Life Metabolism. 1:10-24
People completely lacking body fat (lipodystrophy/lipoatrophy) and those with severe obesity both show profound metabolic and other health issues. Regulating levels of body fat somewhere between these limits would, therefore, appear to be adaptive. T
Autor:
Joel K. Elmquist, Amanda G. Arnold, Madison Granier, Charlotte E. Lee, Jiwon Lee, Teppei Fujikawa, Carlos M. Castorena, Natalie J. Michael, Arely Salazar Tinajero, Alexandre Caron, William L. Holland, Syann Lee, Chelsea Limboy, Newaz Ahmed, Chen Liu, Jay D. Horton, Simeng Wang
Publikováno v:
Am J Physiol Endocrinol Metab
Cannabinoid 1 receptor (CB1R) inverse agonists reduce body weight and improve several parameters of glucose homeostasis. However, these drugs have also been associated with deleterious side effects. CB1R expression is widespread in the brain and in p