Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Joel Isohookana"'
Autor:
Joni Leppänen, Olli Helminen, Heikki Huhta, Joonas H. Kauppila, Joel Isohookana, Kirsi-Maria Haapasaari, Seppo Parkkila, Juha Saarnio, Petri P. Lehenkari, Tuomo J. Karttunen
Publikováno v:
World Journal of Surgical Oncology, Vol 16, Iss 1, Pp 1-9 (2018)
Abstract Background HIF-1alpha and CAIX proteins are commonly expressed under hypoxic conditions, but other regulatory factors have been described as well. Pancreatic ductal adenocarcinoma (PDAC) is characterized by hypoxia and strong stromal reactio
Externí odkaz:
https://doaj.org/article/0dc376d4f4df491fa39525e7c811b4c6
Autor:
Peeter Karihtala, Heikki Huhta, Kirsi-Maria Haapasaari, Juha Saarnio, Petri Lehenkari, Ville Lindholm, Joonas H. Kauppila, Olli Helminen, Tuomo J. Karttunen, Joni Leppänen, Joel Isohookana
Publikováno v:
Pancreas
Supplemental digital content is available in the text.
Objectives Pancreatic ductal adenocarcinoma (PDAC) is characterized by abundant stroma with increased expression of tenascin C and fibronectin. Their role and tumor-stroma ratio in PDAC are
Objectives Pancreatic ductal adenocarcinoma (PDAC) is characterized by abundant stroma with increased expression of tenascin C and fibronectin. Their role and tumor-stroma ratio in PDAC are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d3a1f90310a63d00bb319083f7f5506
https://doi.org/10.1097/mpa.0000000000001195
https://doi.org/10.1097/mpa.0000000000001195
Autor:
Kirsi-Maria Haapasaari, Joel Isohookana, Heikki Huhta, Joni Leppänen, Joonas H. Kauppila, Seppo Parkkila, Tuomo J. Karttunen, Juha Saarnio, Petri Lehenkari, Olli Helminen
Publikováno v:
World Journal of Surgical Oncology, Vol 16, Iss 1, Pp 1-9 (2018)
World Journal of Surgical Oncology
World Journal of Surgical Oncology
Background HIF-1alpha and CAIX proteins are commonly expressed under hypoxic conditions, but other regulatory factors have been described as well. Pancreatic ductal adenocarcinoma (PDAC) is characterized by hypoxia and strong stromal reaction and has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::470111c33216a6aa4d77aecf2964c917
http://link.springer.com/article/10.1186/s12957-018-1432-4
http://link.springer.com/article/10.1186/s12957-018-1432-4
Autor:
Peeter Karihtala, Tuomo J. Karttunen, Olli Helminen, Joel Isohookana, Petri Lehenkari, Joonas H. Kauppila, Seppo Parkkila, Juha Saarnio, Joni Leppänen, Heikki Huhta, Kirsi-Maria Haapasaari
Publikováno v:
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. 126(11)
Pancreatic cancer arises from precursor lesions called pancreatic intraepithelial neoplasia (PanIN) characterized by inflammatory microenvironment. In pancreatic cancer, strong innate immunity and hypoxia responses are typical. Occurrence and relatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eaa4fb22704d23bd24c9086ead6ddf3
https://pubmed.ncbi.nlm.nih.gov/30357962
https://pubmed.ncbi.nlm.nih.gov/30357962
Publikováno v:
Anticancer Research. 38
Background/aim The role of histone demethylators, such as Jumonji domain 2 (JMJD2/KDM4) proteins, and histone deacetylases, such as sirtuins (SIRT) is poorly characterized in pancreatic carcinomas while they have a major role in the carcinogenesis of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5159dd629ebc1eb71c369f5b697024d6
https://doi.org/10.21873/anticanres.12474
https://doi.org/10.21873/anticanres.12474
Background We studied the expression of some major proteins involved in cell-cycle regulation and DNA repair, the roles of which are not well known in pancreatic ductal adenocarcinoma (PDAC), but which have a significant impact on carcinogenesis of m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6274934246fe4a3cfd7c780e1ec0d1d8
http://urn.fi/urn:nbn:fi-fe2018103039042
http://urn.fi/urn:nbn:fi-fe2018103039042
Autor:
Heikki Huhta, Kirsi-Maria Haapasaari, Joni Leppänen, Joonas H. Kauppila, Tuomo J. Karttunen, Olli Helminen, Joel Isohookana, Petri Lehenkari, Juha Saarnio
Publikováno v:
Virchows Archiv : an international journal of pathology. 470(4)
Pancreatic cancer remains one of the deadliest malignancies in the world. Inflammatory response and tumor environment are thought to play a major role in its pathogenesis. Knowledge on TLR expression and impact on patient survival in pancreatic cance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::410a92e35bde2e81d956a1a68dee886f
https://pubmed.ncbi.nlm.nih.gov/28191612
https://pubmed.ncbi.nlm.nih.gov/28191612
Publikováno v:
Anticancer research. 36(1)
The role of the redox-regulating peroxiredoxin (Prx) enzymes I-VI in pancreatic carcinoma is poorly characterized.The expression of Prxs I, II, III, V and VI was immunohistochemically evaluated in benign pancreas and in 69 pancreatic adenocarcinoma s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::38f6a45504170a2c2e53796297894bc9
https://pubmed.ncbi.nlm.nih.gov/26722077
https://pubmed.ncbi.nlm.nih.gov/26722077
Publikováno v:
Diagnostic Pathology
Background Oxidative stress and redox-regulating enzymes may potentially accelerate pancreatic carcinogenesis and also affect chemoresistance. Recently major antioxidant response regulator NF-E2-related factor 2 (Nrf2) has been linked to poor prognos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da17bc7316be4c2e1e3e57ad63428d3c
https://pubmed.ncbi.nlm.nih.gov/25879528
https://pubmed.ncbi.nlm.nih.gov/25879528