Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Joel I Perez-Perri"'
Autor:
Yang Zhou, Partho Sarothi Ray, Jianguo Zhu, Frank Stein, Mandy Rettel, Thileepan Sekaran, Sudeep Sahadevan, Joel I. Perez-Perri, Eva K. Roth, Ola Myklebost, Leonardo A. Meza-Zepeda, Andreas von Deimling, Chuli Fu, Annika N. Brosig, Kjetil Boye, Michaela Nathrath, Claudia Blattmann, Burkhard Lehner, Matthias W. Hentze, Andreas E. Kulozik
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Osteosarcoma is the most common primary malignant bone tumor with a strong tendency to metastasize, limiting the prognosis of affected patients. Genomic, epigenomic and transcriptomic analyses have demonstrated the exquisite molecular comple
Externí odkaz:
https://doaj.org/article/c8a044416b63443ebe99465720d460f3
Autor:
Andrés Dekanty, Nuria M Romero, Agustina P Bertolin, María G Thomas, Claudia C Leishman, Joel I Perez-Perri, Graciela L Boccaccio, Pablo Wappner
Publikováno v:
PLoS Genetics, Vol 6, Iss 6, p e1000994 (2010)
Hypoxia-inducible factors (HIFs) are a family of evolutionary conserved alpha-beta heterodimeric transcription factors that induce a wide range of genes in response to low oxygen tension. Molecular mechanisms that mediate oxygen-dependent HIF regulat
Externí odkaz:
https://doaj.org/article/77797d9c1feb40c79efdb23ea4dd140d
Autor:
Joel I. Perez-Perri, Dunja Ferring-Appel, Ina Huppertz, Thomas Schwarzl, Sudeep Sahadevan, Frank Stein, Mandy Rettel, Bruno Galy, Matthias W. Hentze
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract System-wide approaches have unveiled an unexpected breadth of the RNA-bound proteomes of cultured cells. Corresponding information regarding RNA-binding proteins (RBPs) of mammalian organs is still missing, largely due to technical challenge
Externí odkaz:
https://doaj.org/article/623024aa03ed4b4c9d0a084cb337b03c
Autor:
Joel I. Perez-Perri, Birgit Rogell, Thomas Schwarzl, Frank Stein, Yang Zhou, Mandy Rettel, Annika Brosig, Matthias W. Hentze
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
RNA interactome capture allows the detailed investigation of RNA-bound proteomes. Here the authors describe enhanced RNA-interactome capture using LNA-modified probes for increased sensitivity and specificity.
Externí odkaz:
https://doaj.org/article/76eaf12d527848aa9f4fbd5d49b9c9e2
Autor:
Maud Dupont, Tim Krischuns, Quentin Giai-Gianetto, Sylvain Paisant, Stefano Bonazza, Jean-Baptiste Brault, Thibaut Douché, Joel I Perez-Perri, Matthias W Hentze, Stephen Cusack, Mariette Matondo, Catherine Isel, David G Courtney, Nadia Naffakh
Recent technical advances have significantly improved our understanding of the RNA-binding protein (RBP) repertoire present within eukaryotic cells, with a particular focus on the RBPs that interact with cellular polyadenylated mRNAs. However, recent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27588ea7439c895daeb07877156ed5b9
https://hal-pasteur.archives-ouvertes.fr/pasteur-04093384
https://hal-pasteur.archives-ouvertes.fr/pasteur-04093384
Autor:
Joel I. Perez-Perri, Dunja Ferring-Appel, Ina Huppertz, Thomas Schwarzl, Frank Stein, Mandy Rettel, Bruno Galy, Matthias W. Hentze
SummarySystem-wide approaches have unveiled an unexpected breadth of the RNA-bound proteomes of cultured cells. Corresponding information regarding RNA-binding proteins (RBPs) of mammalian organs is still missing, largely due to technical challenges.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::180c762c2bd82464e8ae4879ff7d45cb
https://doi.org/10.1101/2022.02.10.479897
https://doi.org/10.1101/2022.02.10.479897
Autor:
Matthias W. Hentze, Mandy Rettel, Gabriele Neu-Yilik, Frank Stein, Yang Zhou, Thomas Schwarzl, Andreas E. Kulozik, Joel I. Perez-Perri, Michael Backlund, Annika Brosig
Publikováno v:
Nucleic Acids Research
Cellular stress causes multifaceted reactions to trigger adaptive responses to environmental cues at all levels of the gene expression pathway. RNA-binding proteins (RBP) are key contributors to stress-induced regulation of RNA fate and function. Her
Autor:
Ina Huppertz, Joel I. Perez-Perri, Panagiotis Mantas, Thileepan Sekaran, Thomas Schwarzl, Francesco Russo, Dunja Ferring-Appel, Zuzana Koskova, Lyudmila Dimitrova-Paternoga, Eleni Kafkia, Janosch Hennig, Pierre A. Neveu, Kiran Patil, Matthias W. Hentze
Publikováno v:
Mol Cell
Huppertz, I, Perez-Perri, J I, Mantas, P, Sekaran, T, Schwarzl, T, Russo, F, Ferring-Appel, D, Koskova, Z, Dimitrova-Paternoga, L, Kafkia, E, Hennig, J, Neveu, P A, Patil, K & Hentze, M W 2022, ' Riboregulation of Enolase 1 activity controls glycolysis and embryonic stem cell differentiation ', Molecular Cell, vol. 82, no. 14, pp. 2666-2680.e11 . https://doi.org/10.1016/j.molcel.2022.05.019
Huppertz, I, Perez-Perri, J I, Mantas, P, Sekaran, T, Schwarzl, T, Russo, F, Ferring-Appel, D, Koskova, Z, Dimitrova-Paternoga, L, Kafkia, E, Hennig, J, Neveu, P A, Patil, K & Hentze, M W 2022, ' Riboregulation of Enolase 1 activity controls glycolysis and embryonic stem cell differentiation ', Molecular Cell, vol. 82, no. 14, pp. 2666-2680.e11 . https://doi.org/10.1016/j.molcel.2022.05.019
Differentiating stem cells must coordinate their metabolism and fate trajectories. Here, we report that the cat-alytic activity of the glycolytic enzyme Enolase 1 (ENO1) is directly regulated by RNAs leading to metabolic rewiring in mouse embryonic s
Autor:
Panagiotis Mantas, Thomas Schwarzl, Joel I. Perez-Perri, Janosch Hennig, Matthias W. Hentze, Thileepan Sekaran, Ina Huppertz, Lyudmila Dimitrova-Paternoga, Pierre A. Neveu
Cells must coordinate their metabolism and fate trajectories (1, 2), but the underlying mechanisms are only beginning to be discovered. To understand why the glycolytic enzyme enolase 1 (ENO1) binds RNA (3–6), we studied this phenomenon in vitro, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd953506de72b6c611bc1dd07c44eb71
https://doi.org/10.1101/2020.10.14.337444
https://doi.org/10.1101/2020.10.14.337444
Autor:
Caroline E. Lenz, Matthias W. Hentze, Joel I. Perez-Perri, Marko Noerenberg, Shabaz Mohammed, Alfredo Castello, Wael Kamel
Publikováno v:
Nat Protoc
Interactions between RNA-binding proteins (RBPs) and RNAs are critical to cell biology. However, methods to comprehensively and quantitatively assess these interactions within cells were lacking. RNA interactome capture (RIC) uses in vivo UV crosslin