Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Joel H. Martin"'
Autor:
Christopher Daly, Gavin Thurston, John S. Rudge, Douglas MacDonald, Gang Chen, Joel H. Martin, Tammy Huang, Ergang Shi, Frank J. Delfino, Jing Shan, Terra B. Potocky, Ashique Rafique, Jeanette L. Fairhurst, Liangfen Fan, Katie Yang, Bo Luan, Carla Castanaro, Li Zhang
EGFR blocking antibodies are approved for the treatment of colorectal cancer and head and neck squamous cell carcinoma (HNSCC). Although ERBB3 signaling has been proposed to limit the effectiveness of EGFR inhibitors, the underlying molecular mechani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6b6648e17cc46bf07df9b26c704c96c
https://doi.org/10.1158/1535-7163.c.6536475
https://doi.org/10.1158/1535-7163.c.6536475
Autor:
Christopher Daly, Gavin Thurston, John S. Rudge, Douglas MacDonald, Gang Chen, Joel H. Martin, Tammy Huang, Ergang Shi, Frank J. Delfino, Jing Shan, Terra B. Potocky, Ashique Rafique, Jeanette L. Fairhurst, Liangfen Fan, Katie Yang, Bo Luan, Carla Castanaro, Li Zhang
PDF - 78K, Effect of REGN1400 and REGN955 on ligand-induced signaling by ERBB3 and EGFR, respectively.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71092c3804bd3679a5040c51a04f7d1a
https://doi.org/10.1158/1535-7163.22500492
https://doi.org/10.1158/1535-7163.22500492
Autor:
Christopher Daly, Gavin Thurston, John S. Rudge, Douglas MacDonald, Gang Chen, Joel H. Martin, Tammy Huang, Ergang Shi, Frank J. Delfino, Jing Shan, Terra B. Potocky, Ashique Rafique, Jeanette L. Fairhurst, Liangfen Fan, Katie Yang, Bo Luan, Carla Castanaro, Li Zhang
PDF - 56K, Measurement of REGN1400 and REGN955 binding affinities.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12c1a8712c837e8c8041bfee1e5887b7
https://doi.org/10.1158/1535-7163.22500489.v1
https://doi.org/10.1158/1535-7163.22500489.v1
Autor:
Seongwon Hong, Jie Dai, Aynur Hermann, William Poueymirou, Andrew J. Murphy, Erica Ullman, Matt Liu, Gavin Thurston, Elena Burova, Gabor Halasz, Omaira Allbritton, Jerry Pei, Amy Woodruff, William C. Olson, Douglas MacDonald, Terra Potocky, Markus Mohrs, Ella Ioffe, Joel H. Martin, Ashique Rafique
Publikováno v:
Molecular Cancer Therapeutics. 18:2051-2062
In the tumor microenvironment, multiple inhibitory checkpoint receptors can suppress T-cell function, thereby enabling tumor immune evasion. Blockade of one of these checkpoint receptors, PD-1, with therapeutic antibodies has produced positive clinic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dab7f97c3aa3eeaf1775cdb52374a36c
https://doi.org/10.1158/1535-7163.mct-18-1376
https://doi.org/10.1158/1535-7163.mct-18-1376
Autor:
Thomas DiCioccio, Nicholas J. Papadopoulos, Albert Torri, Thomas J. Daly, Giane Sumner, Camille Georgaros, Joel H. Martin, Ashique Rafique
Publikováno v:
Bioanalysis. 11:381-392
Aim: To evaluate the accuracy of the Quantikine Human VEGF Immunoassay (R&D Systems) in the presence of VEGF inhibitors. Materials & Methods: Quantikine VEGF ELISA (R&D), anti-VEGF165 mAb (R&D), VEGF165 and aflibercept (Regeneron), ranibizumab and be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::222f287dc262a8281e03fafa9f263179
https://doi.org/10.4155/bio-2018-0096
https://doi.org/10.4155/bio-2018-0096
Autor:
Drew Dudgeon, Xuan Ye, Jacqueline J. Warsaw, Evan Herlihy, Erica Ullman, Arpita Pawashe, William Poueymirou, Patrick Poon, Ilyssa Ramos, Dharani Ajithdoss, Bei Wang, Jacquelynn Golubov, Nicole Stokes Oristian, Eric Smith, Matthew A. Sleeman, George D. Yancopoulos, Rabih Slim, Alison Crawford, Priyanka Ram, William C. Olson, Chia-Jen Siao, Andrew J. Murphy, Hassan Ahmed, Terra Potocky, Janelle C. Waite, Danica Chiu, Gavin Thurston, Dimitris Skokos, Tammy T. Huang, Erin Oswald, Lauren Canova, Adelekan Oyejide, Stephen Godin, Lauren Havel, Kathleen Provoncha, Qi Wu, Douglas MacDonald, Miguel Lazo, Kevin Yu, Joel H. Martin, Ashique Rafique, Kristin Vazzana, John C. Lin, Lauric Haber, Jessica R. Kirshner, Aynur Hermann, Julie Kim
Publikováno v:
Science Translational Medicine. 12
T cell activation is initiated upon binding of the T cell receptor (TCR)/CD3 complex to peptide-major histocompatibility complexes ("signal 1"); activation is enhanced by engagement of a second "costimulatory" receptor, such as the CD28 receptor on T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fdeea24fdd9f144f77f6e92ee9ca0bb
https://doi.org/10.1126/scitranslmed.aaw7888
https://doi.org/10.1126/scitranslmed.aaw7888
Autor:
Andrew B. Ward, Christos A. Kyratsous, Ricardo Carrion, Gabriella Worwa, William D. Pratt, Gang Chen, William C. Olson, Terra Potocky, Joel H. Martin, Karl J. Erlandson, John C. Trefry, Ashique Rafique, Peter W. Mason, Hilary M. Staples, Tammy T. Huang, Hannah L. Turner, Robert Babb, Drew Dudgeon, Leah Lipsich, Joshua D. Shamblin, Ying Yan, Yasuteru Sakurai, Thomas M Dreier, Manu Anantpadma, Kevin Yu, Marcela Torres, Sandra L. Bixler, Suzanne E. Wollen, Charles D. Murin, Neil Stahl, Justine M. Zelko, Melissa S Willis, Robert A. Davey, Darya Burakov, Jeanette L. Fairhurst, Ashok Badithe, Margaret L. Pitt, Franco Rossi, Taylor B. Chance, Kimberly Armstrong, Kristen E. Pascal
Publikováno v:
The Journal of Infectious Diseases
Background For most classes of drugs, rapid development of therapeutics to treat emerging infections is challenged by the timelines needed to identify compounds with the desired efficacy, safety, and pharmacokinetic profiles. Fully human monoclonal a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48fdd30e7fa7a70f592379ed4387a859
Autor:
Amanda Dorvilliers, Venus Lai, Jon Popke, Joel H. Martin, Ashique Rafique, William C. Olson, Omaira Allbritton, William Poueymirou, Matt Liu, Amy Woodruff, Andrew J. Murphy, Terra Potocky, Janelle C. Waite, Gavin Thurston, Markus Mohrs, Ella Ioffe, Tammy T. Huang, Joel Kantrowitz, Israel Lowy, Seongwon Hong, Qi Wu, Douglas MacDonald, Dimitris Skokos, Aynur Hermann, Elena Burova, Elena Garnova
Publikováno v:
Molecular Cancer Therapeutics. 16:861-870
The Programmed Death-1 (PD-1) receptor delivers inhibitory checkpoint signals to activated T cells upon binding to its ligands PD-L1 and PD-L2 expressed on antigen-presenting cells and cancer cells, resulting in suppression of T-cell effector functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8aa8e74dc8c8263abc16819a959686aa
https://doi.org/10.1158/1535-7163.mct-16-0665
https://doi.org/10.1158/1535-7163.mct-16-0665
Autor:
William C. Olson, Thomas Nittoli, Andres E. Perez Bay, Douglas MacDonald, Frank Delfino, Nithya Thambi, Julian Andreev, Joel H. Martin, Ashique Rafique, Jessica R. Kirshner, Marcus Kelly, Gavin Thurston, Christopher Daly, Arthur Kunz
Publikováno v:
Molecular Cancer Therapeutics. 16:681-693
The properties of cell surface proteins targeted by antibody–drug conjugates (ADCs) have not been fully exploited; of particular importance are the rate of internalization and the route of intracellular trafficking. In this study, we compared the t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25c536a622a8abc4de38751e65fd163c
https://doi.org/10.1158/1535-7163.mct-16-0658
https://doi.org/10.1158/1535-7163.mct-16-0658
Autor:
Shao Ning Yang, Rabih Slim, Lauren Canova, Andrew J. Murphy, Macdonald Lynn, Jacqueline J. Warsaw, Cagan Gurer, Erica Ullman, Arpita Pawashe, Lauric Haber, Aynur Hermann, Ilyssa Ramos, Gang Chen, Jennifer Stella, Jacquelynn Golubov, Teresa Schulenburg, George D. Yancopoulos, Joel H. Martin, Jennifer Finney, Dimitris Skokos, Ashique Rafique, Elizabeth Navarro, Matthew A. Sleeman, Elena Garnova, Nicole Stokes Oristian, Robert Babb, Xuan Ye, Randi Foster, Julie Kim, William Poueymirou, Qi Wu, Douglas MacDonald, Hassan Ahmed, William C. Olson, Clarissa Lett, Erin Oswald, Janelle C. Waite, Israel Lowy, Stephen Godin, Eric Smith, Pamela Krueger, Devon Grote, Patrick Poon, John C. Lin, Drew Dudgeon, Evan Herlihy, Bei Wang, Amanda Dorvilliers, Dharani Ajithdoss, Jenny Xiao, Christopher Daly, Vishal Kamat, Gavin Thurston, Chia-Jen Siao
Publikováno v:
Science translational medicine. 12(549)
Monoclonal antibodies that block the programmed cell death 1 (PD-1) checkpoint have revolutionized cancer immunotherapy. However, many major tumor types remain unresponsive to anti-PD-1 therapy, and even among responsive tumor types, most of the pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc9e0670c5d21cb293213bc474b8c8f3
https://pubmed.ncbi.nlm.nih.gov/32581132
https://pubmed.ncbi.nlm.nih.gov/32581132