Výsledky vyhledávání - "Joel H Graber"

Akademický článek

Differential effects of RASA3 mutations on hematopoiesis are profoundly influenced by genetic background and molecular variant.

Autor: Raymond F Robledo, Steven L Ciciotte, Joel H Graber, Yue Zhao, Amy J Lambert, Babette Gwynn, Nathaniel J Maki, Elena C Brindley, Emily Hartman, Lionel Blanc, Luanne L Peters

Publikováno v: PLoS Genetics, Vol 16, Iss 12, p e1008857 (2020)

Studies of the severely pancytopenic scat mouse model first demonstrated the crucial role of RASA3, a dual RAS and RAP GTPase activating protein (GAP), in hematopoiesis. RASA3 is required for survival in utero; germline deletion is lethal at E12.5-13

Externí odkaz: https://doaj.org/article/6b568668580f496e80d868e40f22d85c

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Akademický článek

Patterns of recombination activity on mouse chromosome 11 revealed by high resolution mapping.

Autor: Timothy Billings, Evelyn E Sargent, Jin P Szatkiewicz, Nicole Leahy, Il-Youp Kwak, Nazira Bektassova, Michael Walker, Terry Hassold, Joel H Graber, Karl W Broman, Petko M Petkov

Publikováno v: PLoS ONE, Vol 5, Iss 12, p e15340 (2010)

The success of high resolution genetic mapping of disease predisposition and quantitative trait loci in humans and experimental animals depends on the positions of key crossover events around the gene of interest. In mammals, the majority of recombin

Externí odkaz: https://doaj.org/article/20ddfe8e16814514a2ecf91c494f4d48

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Akademický článek

Probe-level analysis of expression microarrays characterizes isoform-specific degradation during mouse oocyte maturation.

Autor: Jesse Salisbury, Keith W Hutchison, Karen Wigglesworth, John J Eppig, Joel H Graber

Publikováno v: PLoS ONE, Vol 4, Iss 10, p e7479 (2009)

Gene expression microarrays have provided many insights into changes in gene expression patterns between different tissue types, developmental stages, and disease states. Analyses of these data focused primarily measuring the relative abundance of tr

Externí odkaz: https://doaj.org/article/eff0193497d3460392f3a5441e0759e3

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Akademický článek

The recombinational anatomy of a mouse chromosome.

Autor: Kenneth Paigen, Jin P Szatkiewicz, Kathryn Sawyer, Nicole Leahy, Emil D Parvanov, Siemon H S Ng, Joel H Graber, Karl W Broman, Petko M Petkov

Publikováno v: PLoS Genetics, Vol 4, Iss 7, p e1000119 (2008)

Among mammals, genetic recombination occurs at highly delimited sites known as recombination hotspots. They are typically 1-2 kb long and vary as much as a 1,000-fold or more in recombination activity. Although much is known about the molecular detai

Externí odkaz: https://doaj.org/article/1d3f0431301c42e79c7acfd157d50424

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Akademický článek

Evidence of a large-scale functional organization of Mammalian chromosomes.

Autor: Petko M Petkov, Joel H Graber, Gary A Churchill, Keith DiPetrillo, Benjamin L King, Kenneth Paigen

Publikováno v: PLoS Biology, Vol 5, Iss 5, p e127; author reply e128 (2007)

Externí odkaz: https://doaj.org/article/83cfb9893a7240518f32b86328ab37bc

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Akademický článek

Evidence of a large-scale functional organization of mammalian chromosomes.

Autor: Petko M Petkov, Joel H Graber, Gary A Churchill, Keith DiPetrillo, Benjamin L King, Kenneth Paigen

Publikováno v: PLoS Genetics, Vol 1, Iss 3, p e33 (2005)

Evidence from inbred strains of mice indicates that a quarter or more of the mammalian genome consists of chromosome regions containing clusters of functionally related genes. The intense selection pressures during inbreeding favor the coinheritance

Externí odkaz: https://doaj.org/article/daeba5671dc94687973c61c659af502f

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