Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Joel Geoghegan"'
Autor:
Maarten J. IJzerman, Jasper de Boer, Arun Azad, Koen Degeling, Joel Geoghegan, Chelsee Hewitt, Frédéric Hollande, Belinda Lee, Yat Ho To, Richard W. Tothill, Gavin Wright, Jeanne Tie, Sarah-Jane Dawson
Publikováno v:
Diagnostics, Vol 11, Iss 1, p 103 (2021)
Blood-based liquid biopsies are considered a new and promising diagnostic and monitoring tool for cancer. As liquid biopsies only require a blood draw, they are non-invasive, potentially more rapid and assumed to be a less costly alternative to genom
Externí odkaz:
https://doaj.org/article/0cfa62b0fdea4a478afe42a86af7cbe7
Autor:
Shu Ly Lim, Zhi Peng Qu, R Daniel Kortschak, David M Lawrence, Joel Geoghegan, Anna-Lena Hempfling, Martin Bergmann, Christopher C Goodnow, Christopher J Ormandy, Lee Wong, Jeff Mann, Hamish S Scott, Duangporn Jamsai, David L Adelson, Moira K O'Bryan
Publikováno v:
PLoS Genetics, Vol 11, Iss 12, p e1005782 (2015)
Externí odkaz:
https://doaj.org/article/8d893ef0cd6a4757964e622bdb13063f
Autor:
Shu Ly Lim, Zhi Peng Qu, R Daniel Kortschak, David M Lawrence, Joel Geoghegan, Anna-Lena Hempfling, Martin Bergmann, Christopher C Goodnow, Christopher J Ormandy, Lee Wong, Jeff Mann, Hamish S Scott, Duangporn Jamsai, David L Adelson, Moira K O'Bryan
Publikováno v:
PLoS Genetics, Vol 11, Iss 10, p e1005620 (2015)
piRNAs are critical for transposable element (TE) repression and germ cell survival during the early phases of spermatogenesis, however, their role in adult germ cells and the relative importance of piRNA methylation is poorly defined in mammals. Usi
Externí odkaz:
https://doaj.org/article/696a274f282f4f478e57fd44243324b3
Autor:
Rachel Hall, Catherine Luxford, Andreas W. Schreiber, Lesley Rawlings, David J. Torpy, John Toubia, Sunita M C De Sousa, Talia Novos, Jinghua Feng, Nicola K. Poplawski, Tristan Hardy, Michael E. Buckland, Roderick J. Clifton-Bligh, Joel Geoghegan, Paul Wang, Hamish S. Scott
Publikováno v:
Journal of the Endocrine Society
Context Germline mutations in the succinate dehydrogenase genes (SDHA/B/C/D, SDHAF2—collectively, “SDHx”) have been implicated in paraganglioma (PGL), renal cell carcinoma (RCC), gastrointestinal stromal tumor (GIST), and pituitary adenoma (PA)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ac4203f8a922a40f95ed92774764e01
https://hdl.handle.net/11541.2/145422
https://hdl.handle.net/11541.2/145422
Autor:
Natasha Friend, Duncan R. Hewett, Peter I. Croucher, Joel Geoghegan, David M. Lawrence, Andrew C.W. Zannettino, Jacqueline E. Noll, Kate Vandyke
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 19, Iss 12, Pp 972-981 (2017)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
Multiple myeloma (MM) is a hematological malignancy resulting from the uncontrolled proliferation of antibody-producing plasma cells in the bone marrow. At diagnosis, independent plasma cell tumors are found throughout the skeleton. The recirculation
Autor:
Hamish S. Scott, Andreas W. Schreiber, Lesley Rawlings, Roderick J. Clifton-Bligh, Nicola K. Poplawski, Tristan Hardy, Grist Scott, John Toubia, Paul Wang, Jingua Feng, Catherine Luxford, Milena Babic, Rachel Hall, David J. Torpy, Joel Geoghegan, Sunita M C De Sousa
Publikováno v:
Journal of the Endocrine Society
Introduction: Germline mutations in the succinate dehydrogenase genes (SDHA/B/C/D, SDHAF2 - collectively, SDHx) have been implicated in paraganglioma (PGL), renal cell carcinoma (RCC), gastrointestinal stromal tumor (GIST) and pituitary adenoma (PA).
Autor:
Teodora Kuzmanovic, Wendy T Parker, Deepak Singhal, Susan Branford, Raghu Gowda, Peer Arts, Jinghua Feng, Rakchha Chhetri, Ian D. Lewis, Sarah Moore, Monika M Kutyna, Suzanne Edwards, Peter Bardy, Joel Geoghegan, Milena Babic, Jaroslaw P. Maciejewski, Richard J D'Andrea, Anna L. Brown, Andreas W. Schreiber, Devendra K Hiwase, Hamish S. Scott, Nimit Singhal, Li Yan A Wee, Luen B. To, Paul Wang, Christopher N. Hahn, Smita Hiwase
Therapy-related myeloid neoplasms (T-MN) are poorly characterized secondary hematological malignancies following chemotherapy/radiotherapy exposure. We compared the clinical and mutational characteristics of T-MN (n = 129) and primary myelodysplastic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5830d3ac3175d481ce991c11ff43983c
https://hdl.handle.net/11541.2/137455
https://hdl.handle.net/11541.2/137455
Autor:
Sarah E. Heron, Yeh Sze Ong, Paul Q. Thomas, Leanne M. Dibbens, Laura Licchetta, Michael G. Ricos, Samuel F. Berkovic, Ingrid E. Scheffer, Stefano Meletti, Bree L. Hodgson, Paolo Tinuper, Sara Baldassari, Francesca Bisulli, Margherita Santucci, Guido Rubboli, Akzam Saidin, James N. Hughes, Tommaso Pippucci, Joel Geoghegan, Marta A. Bayly, Flavia Palombo, Andreas W. Schreiber
Publikováno v:
Annals of Neurology. 79:120-131
Objective Focal epilepsies are the most common form observed and have not generally been considered to be genetic in origin. Recently, we identified mutations in DEPDC5 as a cause of familial focal epilepsy. In this study, we investigated whether mut
Autor:
Deepak, Singhal, Li Yan A, Wee, Monika M, Kutyna, Rakchha, Chhetri, Joel, Geoghegan, Andreas W, Schreiber, Jinghua, Feng, Paul P-S, Wang, Milena, Babic, Wendy T, Parker, Smita, Hiwase, Suzanne, Edwards, Sarah, Moore, Susan, Branford, Teodora, Kuzmanovic, Nimit, Singhal, Raghu, Gowda, Anna L, Brown, Peer, Arts, Luen B, To, Peter G, Bardy, Ian D, Lewis, Richard J, D'Andrea, Jaroslaw P, Maciejewski, Hamish S, Scott, Christopher N, Hahn, Devendra K, Hiwase
Publikováno v:
Leukemia. 33(12)
Therapy-related myeloid neoplasms (T-MN) are poorly characterized secondary hematological malignancies following chemotherapy/radiotherapy exposure. We compared the clinical and mutational characteristics of T-MN (n = 129) and primary myelodysplastic
Autor:
Ian D. Lewis, Raghu Gowda, Smita Hiwase, Li Yan A Wee, Rakchha Chhetri, Monika M Kutyna, Christopher N. Hahn, Joel Geoghegan, Jinghua Feng, Devendra K Hiwase, Hamish S. Scott, Wendy T Parker, Richard J D'Andrea, Anna L. Brown, Luke D Moma, Lucy A. Godley, Nimit Singhal, Andreas W. Schreiber, Peer Arts, Milena Babic, Deepak Singhal
Publikováno v:
Blood. 134:1704-1704
Approximately 8% of un-selected pediatric (Zhang et al, NEJM 2015) and adult (Huang et al, Cell 2018) cancer patients have a deleterious germline (GL) variant. However, the frequency in patients with >2 non-related cancers, a combination of different