NO Exchange for a Water Molecule Favorably Changes Iontophoretic Release of Ruthenium Complexes to the Skin

Autor: Danielle C. A. S. de Santana, Karina Dias, Joel G. Souza, Abayomi T. Ogunjimi, Marina C. Souza, Roberto S. Silva, Renata F. V. Lopez

Publikováno v: Molecules, Vol 22, Iss 1, p 104 (2017)

Ruthenium (Ru) complexes have been studied as promising anticancer agents. Ru nitrosyl complex (Ru-NO) is one which acts as a pro-drug for the release of nitric oxide (NO). The Ru-aqueous complex formed by the exchange of NO for a water molecule afte

Externí odkaz: https://doaj.org/article/af1fa8f4138d4dd58f2c1ed9886913ca

Iontophoresis improved growth reduction of invasive squamous cell carcinoma in topical photodynamic therapy

Autor: Renata Fonseca Vianna Lopez, Joel G. Souza, Patrícia Sper Simão, Camila Nunes Lemos

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
PLoS ONE, Vol 11, Iss 1, p e0145922 (2016)
PLoS ONE

This study examined the potential of iontophoresis in topical photodynamic therapy (PDT) of human invasive squamous cells carcinomas (SCC). SCC was induced in nude BALB/c mice by subcutaneous injection of A431 cells. Tumor penetration and distributio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bef165050b1981f4fc68370bfa0f4f1

Ethanolic Crude Extract and Flavonoids Isolated from Alternanthera maritima: Neutrophil Chemiluminescence Inhibition and Free Radical Scavenging Activity

Autor: Luciana M. Kabeya, Ana Elisa Caleiro Seixas Azzolini, Yara Maria Lucisano-Valim, Alexandre Kanashiro, Rafael R. Tomei, Diones Aparecida Dias, Marcos José Salvador, Joel G. Souza

Publikováno v: Zeitschrift für Naturforschung C. 62:339-347

Extracts from Alternanthera maritima are used in Brazilian folk medicine for the treatment of infectious and inflammatory diseases. Bioassay-guided fractionation of A. maritima aerial parts yielded an ethanolic crude extract, its butanolic fraction a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc507557612229ec35b1fa0c97dfc44b
https://doi.org/10.1515/znc-2007-5-604

Iontophoretic transport kinetics of ketorolac in vitro and in vivo: demonstrating local enhanced topical drug delivery to muscle

Autor: Guilherme M. Gelfuso, Yogeshvar N. Kalia, Tais Gratieri, Ester Pujol-Bello, Renata Fonseca Vianna Lopez, Joel G. Souza

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

The objective of the study was to investigate the iontophoretic delivery kinetics of ketorolac (KT), a highly potent NSAID and peripherally-acting analgesic that is currently indicated to treat moderate to severe acute pain. It was envisaged that, de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bd82ba3ea4575d322070663ef2256a2

Iontophoretic transport of zinc phthalocyanine tetrasulfonic acid as a tool to improve drug topical delivery

Autor: Patrícia Sper Simão, Joel G. Souza, Guilherme M. Gelfuso, Renata Fonseca Vianna Lopez, Antonio Carlos Borges

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Phthalocyanines have been used as systemic photosensitizers because of their high affinity towards tumour tissue, and the high rates of reactive oxygen species produced when they are irradiated during photodynamic therapy. However, the topical admini

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6621d73abfa14b45a73beeddf60ed48c