Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Joel G. Hardman"'
Autor:
Alfred Goodman Gilman, Joel G. Hardman
Publikováno v:
Annual Review of Physiology. 69
Autor:
Neal E. Miller, Adrian R Morrison, Susan E Paris, Gordon H Bower, William H Dantzler, Susan Mineka, David G. Johnson, Ronald E Fox, Joel G. Hardman, Larry R. Squire, Robert G Petersdorf
Publikováno v:
Nature. 369:9-9
Publikováno v:
Metabolism. 24:1139-1144
This study was designed to assess the response of cyclic AMP to “endogenous” hormonal stimulation resulting from insulin-induced hypoglycemia. Insulin was administered to four normal subjects and four adrenalectomized patients. Hypoglycemia resul
Publikováno v:
Biochemistry. 13:4166-4171
Publikováno v:
Journal of Biological Chemistry. 250:374-381
Rat lung homogenates contained significant amounts of guanylate cyclase activity in both 100,000 times g (60 min) particulate and supernatant fractions. In the presence of detergent, the particulate fraction contained 40% as much activity as did the
Publikováno v:
Archives of Biochemistry and Biophysics. 166:135-138
The guanylate cyclase reaction was studied to determine the identity of the product(s) formed other than guanosine-3′,5′-monophosphate (cyclic GMP). Partially purified guanylate cyclase preparations from rat lung catalyzed the formation of nearly
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Enzymology. 384:159-167
Cyclic nucleotide phosphodiesterase activity was measured in whole blood, plasma, and suspensions of platelets and erythrocytes from rats. In fresh whole blood, apparent phosphodiesterase activity was low, but it rose strikingly during the hour after
Publikováno v:
Journal of Clinical Investigation. 56:339-345
This study was designed to elucidate the mechanism of elevation of plasma cyclic AMP in uremic man. Plasma cyclic AMP was measured in 15 normal subjects and in 18 patients with severe renal failure. In some members from both groups the kinetic parame
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Enzymology. 377:174-185
Enzymes in particulate fractions from sea urchin sperm and in soluble fractions from rat lung were shown to catalyze the formation of inosine 3′,5′-monophosphate (cyclic IMP) and of 2′-deoxyguanosine 3′,5′-monophosphate (cyclic dGMP) from I
Publikováno v:
Metabolism. 24:429-437
The effect of 1-norepinephrine on cyclic nucleotide levels was studied in rat ductus deferens. Norepinephrine (0.01-0.3 mM) increased cyclic AMP and cyclic GMP levels in a concentration-dependent manner. Cyclic GMP was increased by about two-fold and