Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Joel G. Chaney"'
Autor:
Scott D. Dyer, Scott E. Belanger, Jessica L. Brill, Joel G. Chaney, Mace G. Barron, Sandy Raimondo, Charles A. Pittinger
Publikováno v:
Environmental Toxicology and Chemistry. 35:2368-2378
Web-based Interspecies Correlation Estimation (ICE) is an application developed to predict the acute toxicity of a chemical from 1 species to another taxon. Web-ICE models use the acute toxicity value for a surrogate species to predict effect values
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d206a91c83086692cab65be2402d9057
https://doi.org/10.1002/etc.3375
https://doi.org/10.1002/etc.3375
Autor:
Clarence Bohne, Keith Casey, Katherine Sarlo, Charles Fryer, Edwin D. Clark, Mike Kuhn, Karen Blackburn, Janine Anne Flood, Joel G. Chaney, Suzanne Neu, Jeff T. Grothaus, Dana Abbott
Publikováno v:
Toxicology. 263:117-126
Understanding tissue distribution and clearance of nanomaterials following different routes of exposure is needed for risk assessment. F344 female rats received single or multiple exposures to 20 nm, 100 nm or 1000 nm latex fluorospheres by intraveno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cbcdbe4ba3ed3b3399e6f3f894b1300
https://doi.org/10.1016/j.tox.2009.07.002
https://doi.org/10.1016/j.tox.2009.07.002
Autor:
Jessica L, Brill, Scott E, Belanger, Joel G, Chaney, Scott D, Dyer, Sandy, Raimondo, Mace G, Barron, Charles A, Pittinger
Publikováno v:
Environmental toxicology and chemistry. 35(9)
Web-based Interspecies Correlation Estimation (ICE) is an application developed to predict the acute toxicity of a chemical from 1 species to another taxon. Web-ICE models use the acute toxicity value for a surrogate species to predict effect values
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c828655ad34b5b33db0fd1810871777a
https://pubmed.ncbi.nlm.nih.gov/26792236
https://pubmed.ncbi.nlm.nih.gov/26792236
Publikováno v:
Environmental Science & Technology. 40:3102-3111
Environmental risk assessments often use multiple single species toxicity test results and species sensitivity distributions (SSDs) to derive a predicted no-effect concentration in the environment, typically the 5th percentile of the SSD, termed the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4d241ec329f12db37d72d0474513b54
https://doi.org/10.1021/es051738p
https://doi.org/10.1021/es051738p
Autor:
Joel G. Chaney, Morrall Stephen William, G. Frank Gerberick, Jean-Pierre Lepoittevin, Ruth E. Bailey, Jeffrey D. Vassallo
Publikováno v:
Toxicological Sciences. 81:332-343
Allergic contact dermatitis resulting from skin sensitization is a common occupational and environmental health problem. In recent years, the local lymph node assay (LLNA) has emerged as a practical option for assessing the skin sensitization potenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11bb36d4008eef9333fa3b1359161cdf
https://doi.org/10.1093/toxsci/kfh213
https://doi.org/10.1093/toxsci/kfh213
Autor:
Ian Kimber, Petra S. Kern, Grace Patlewicz, G. Frank Gerberick, Cindy A. Ryan, David A. Basketter, Joel G. Chaney, Rebecca J. Dearman, Catherine J. Betts
Publikováno v:
Journal of applied toxicology : JAT. 28(4)
The local lymph node assay (LLNA) is a skin sensitization test that provides animal welfare benefits. To reduce animal usage further, a modified version (rLLNA) was proposed. Conducting the rLLNA as a screening test with a single high dose group and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42b2ad93322a63487db308a61ee5fc77
https://pubmed.ncbi.nlm.nih.gov/17879259
https://pubmed.ncbi.nlm.nih.gov/17879259
Autor:
Ian Kimber, Rebecca J. Dearman, G. Frank Gerberick, David A. Basketter, Cindy A. Ryan, Joel G. Chaney, Petra S. Kern
Publikováno v:
Cutaneous and ocular toxicology. 26(2)
The assessment of the potency of a skin sensitizing chemical is a key starting point for its subsequent risk assessment/management. The Local Lymph Node Assay can provide information on the relative skin sensitizing potency of contact allergens by in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0abb5dd3ff09ed21f2201d6ab6484db
https://pubmed.ncbi.nlm.nih.gov/17612980
https://pubmed.ncbi.nlm.nih.gov/17612980
Autor:
Jeffrey D. Vassallo, Jean-Pierre Lepoittevin, Brad B. Price, Leslie M. Foertsch, G. Frank Gerberick, Joel G. Chaney
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 97(2)
In the interest of reducing animal use, in vitro alternatives for skin sensitization testing are under development. One unifying characteristic of chemical allergens is the requirement that they react with proteins for the effective induction of skin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cc01e1d2eeaf5a0ac533ccdf6a2da4f
https://pubmed.ncbi.nlm.nih.gov/17400584
https://pubmed.ncbi.nlm.nih.gov/17400584
Autor:
Jay P. Tiesman, Joel G. Chaney, David P. Gibson, Marilyn J. Aardema, Ting Hu, Suzanne M. Torontali, Gregory J. Carr
Publikováno v:
Mutation research. 549(1-2)
During the safety evaluation process of new drugs and chemicals, a battery of genotoxicity tests is conducted starting with in vitro genotoxicity assays. Obtaining positive results in in vitro genotoxicity tests is not uncommon. Follow-up studies to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a18af5b1462d321b36a4d6ba2f186ae
https://pubmed.ncbi.nlm.nih.gov/15120960
https://pubmed.ncbi.nlm.nih.gov/15120960
Autor:
Robert A. Skinner, Rebecca J. Dearman, Ian Kimber, Joel G. Chaney, L W Cruse, G. Frank Gerberick, Cindy A. Ryan, Ben C. Hulette
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 68(2)
It has been shown that exposure of mice to contact allergens induces B cell activation in the draining lymph nodes (DLN), as seen by an increase in the percentage of B220+ or IgG/IgM+ cells. We have now examined whether the measurement of the percent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b47bc39b7b78210f8c95a9c40168044
https://pubmed.ncbi.nlm.nih.gov/12151637
https://pubmed.ncbi.nlm.nih.gov/12151637