Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Joel G, Belasco"'
Autor:
Jamie Richards, Joel G. Belasco
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101190- (2022)
Summary: Generated by RNA deprotection or cleavage, 5′ monophosphates trigger RNA degradation in all organisms. Here we describe PABLO-QA (Phosphorylation Assay By Ligation of Oligonucleotides and Quantitative Amplification), a sensitive, low-cost
Externí odkaz:
https://doaj.org/article/0bfcb34c9f9447fa944e93f96428f8b2
Autor:
Monica P. Hui, Joel G. Belasco
Publikováno v:
Nucleic Acids Research
A key pathway for mRNA degradation in bacterial cells begins with conversion of the initial 5′-terminal triphosphate to a monophosphate, a modification that renders transcripts more vulnerable to attack by ribonucleases whose affinity for monophosp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5be3967826df5f2daf1475779d2f134a
http://europepmc.org/articles/PMC8565310
http://europepmc.org/articles/PMC8565310
Autor:
Jamie Richards, Joel G Belasco
Publikováno v:
Nucleic acids research.
In countless bacterial species, the lifetimes of most mRNAs are controlled by the regulatory endonuclease RNase E, which preferentially degrades RNAs bearing a 5′ monophosphate and locates cleavage sites within them by scanning linearly from the 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01df18475654ee2e2bcbd741e732771b
https://pubmed.ncbi.nlm.nih.gov/36620905
https://pubmed.ncbi.nlm.nih.gov/36620905
Autor:
Daniel J. Luciano, Joel G. Belasco
Publikováno v:
Proc Natl Acad Sci U S A
Stresses that increase the cellular concentration of dinucleoside tetraphosphates (Np(4)Ns) have recently been shown to impact RNA degradation by inducing nucleoside tetraphosphate (Np(4)) capping of bacterial transcripts. However, neither the mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a41c52768bc3615c89b52b563f0502cc
https://doi.org/10.1073/pnas.1914229117
https://doi.org/10.1073/pnas.1914229117
Autor:
Rose Levenson-Palmer, Daniel J. Luciano, Nikita Vasilyev, Ashok Nuthanakanti, Alexander Serganov, Joel G. Belasco
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Significance Dinucleoside tetraphosphate alarmones function in bacteria as precursors to 5′-terminal nucleoside tetraphosphate (Np 4 ) caps, becoming incorporated at high levels into RNA during stress and thereby influencing transcript lifetimes. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05c4749fa6eb36bc11ea9677b0a0ee68
https://doi.org/10.1073/pnas.2117318119
https://doi.org/10.1073/pnas.2117318119
Autor:
Rose, Levenson-Palmer, Daniel J, Luciano, Nikita, Vasilyev, Ashok, Nuthanakanti, Alexander, Serganov, Joel G, Belasco
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(6)
Dinucleoside tetraphosphates, often described as alarmones because their cellular concentration increases in response to stress, have recently been shown to function in bacteria as precursors to nucleoside tetraphosphate (Np
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::29972faebfaf809ee633cbe9ef7ab517
https://pubmed.ncbi.nlm.nih.gov/35131855
https://pubmed.ncbi.nlm.nih.gov/35131855
Autor:
Mericien Venzon, Ritika Das, Daniel J. Luciano, Julia Burnett, Hyun Shin Park, Joseph Cooper Devlin, Eric T. Kool, Joel G. Belasco, E. Jane Albert Hubbard, Ken Cadwell
Publikováno v:
Cell Host Microbe
SummaryA distinguishing feature of Trichuris nematodes is that these parasitic worms reproduce within the digestive tracts of humans and other mammalian hosts shedding thousands of eggs daily, facilitating their sustained presence in the environment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3404abc4d6c5deb64c9e8fb266b25bb4
https://doi.org/10.1101/2021.08.02.454806
https://doi.org/10.1101/2021.08.02.454806
Autor:
Jamie Richards, Joel G. Belasco
Publikováno v:
Molecular microbiologyREFERENCES. 116(2)
Although riboswitches have long been known to regulate translation initiation and transcription termination, a growing body of evidence indicates that they can also control bacterial RNA lifetimes by acting directly to hasten or impede RNA degradatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94e63d1f37ad5da8b15d8edea4185a32
https://pubmed.ncbi.nlm.nih.gov/33797153
https://pubmed.ncbi.nlm.nih.gov/33797153
Autor:
Jamie Richards, Joel G. Belasco
Publikováno v:
Mol Cell
Riboswitches are thought generally to function by modulating transcription elongation or translation initiation. In rare instances, ligand binding to a riboswitch has been found to alter the rate of RNA degradation by directly stimulating or inhibiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b092ae8b9b3215dedc020ee08b883744
https://pubmed.ncbi.nlm.nih.gov/33212019
https://pubmed.ncbi.nlm.nih.gov/33212019
Autor:
Joel G. Belasco, Nathaniel J. Traaseth, Alexander Serganov, Daniel J. Luciano, Rose Levenson-Palmer, Jamie Richards, Ang Gao, William M. Marsiglia, Nikita Vasilyev
Publikováno v:
Nucleic Acids Research
Vitally important for controlling gene expression in eukaryotes and prokaryotes, the deprotection of mRNA 5′ termini is governed by enzymes whose activity is modulated by interactions with ancillary factors. In Escherichia coli, 5′-end-dependent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa94c302c765b3ea49ddbcdfbadf02d3
https://doi.org/10.1093/nar/gky327
https://doi.org/10.1093/nar/gky327