Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Joel Fernandes Lima"'
Autor:
Joel Fernandes Lima
Publikováno v:
Biblioteca Digital de Teses e Dissertações da USPUniversidade de São PauloUSP.
A constante exposição dos diferentes organismos a agentes que danificam a estrutura da molécula do DNA fez com que a célula desenvolvesse mecanismos de reparo que se mostraram conservados durante a evolução. Em células de mamíferos, as vias d
Autor:
Marcia Regina von Zeska Kress Fagundes, Iran Malavazi, Gustavo H. Goldman, Maria Helena S. Goldman, Marcela Savoldi, Gerhard H. Braus, Elke U. Schwier, Joel Fernandes Lima
Publikováno v:
Genetics. 171:1003-1015
The signalosome (CSN) is a conserved multiprotein complex involved in regulation of eukaryotic development and is also required to activate ribonucleotide reductase for DNA synthesis. In Aspergillus nidulans, csnD/csnE are key regulators of sexual de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7717c29fb63257ac66076c7e1f10836
https://doi.org/10.1534/genetics.105.041376
https://doi.org/10.1534/genetics.105.041376
Autor:
Marcela Savoldi, Steven D. Harris, Marcia Regina von Zeska Kress Fagundes, Joel Fernandes Lima, Maria Helena S. Goldman, Camile P. Semighini, Gustavo H. Goldman, Iran Malavazi
Publikováno v:
Eukaryotic Cell. 4:1239-1252
The ATM/ATR kinases and the Mre11 (Mre11-Rad50-Nbs1) protein complex are central players in the cellular DNA damage response. Here we characterize possible interactions between Aspergillus nidulans uvsB ATR and the Mre11 complex ( scaA NBS1 ). We dem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4266a6f37c900c83ad336df7c121c9c
https://doi.org/10.1128/ec.4.7.1239-1252.2005
https://doi.org/10.1128/ec.4.7.1239-1252.2005
Autor:
Gustavo H. Goldman, Joel Fernandes Lima, Vladimir P. Efimov, Marcia Regina von Zeska Kress Fagundes, Iran Malavazi, Maria Helena S. Goldman
Publikováno v:
Molecular Microbiology. 57:222-237
The Mre11-Rad50-Nbs1 protein complex has emerged as a central component in the human cellular DNA damage response, and recent observations suggest that these proteins are at least partially responsible for the linking of DNA damage detection to DNA r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::937d0db5f16448db529e8d8763310e28
https://doi.org/10.1111/j.1365-2958.2005.04671.x
https://doi.org/10.1111/j.1365-2958.2005.04671.x
Autor:
Marcela Savoldi, Roy E. Larson, Gustavo H. Goldman, Maria Helena S. Goldman, Joel Fernandes Lima, Marcia Regina von Zeska Kress Fagundes, Iran Malavazi
Publikováno v:
Genetics. 167:1629-1641
The DNA damage response is a protective mechanism that ensures the maintenance of genomic integrity. We have used Aspergillus nidulans as a model system to characterize the DNA damage response caused by the antitopoisomerase I drug, camptothecin. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72bb0ae78bbbecc35dbdd7bcaca7643b
https://doi.org/10.1534/genetics.103.024166
https://doi.org/10.1534/genetics.103.024166
Autor:
Gustavo H. Goldman, Maria Helena S. Goldman, Patrícia Alves de Castro, Marcela Savoldi, Iran Malavazi, Joel Fernandes Lima
Publikováno v:
Genetics. 178(2)
Ataxia telangiectasia mutated (ATM) is a phosphatidyl-3-kinase-related protein kinase that functions as a central regulator of the DNA damage response in eukaryotic cells. In humans, mutations in ATM cause the devastating neurodegenerative disease at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df39a5940855bb47628c7871a6cfac6d
https://pubmed.ncbi.nlm.nih.gov/18245360
https://pubmed.ncbi.nlm.nih.gov/18245360
Autor:
Joel Fernandes Lima
Publikováno v:
Biblioteca Digital de Teses e Dissertações da USP
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
A constante exposição dos diferentes organismos a agentes que danificam a estrutura da molécula do DNA fez com que a célula desenvolvesse mecanismos de reparo que se mostraram conservados durante a evolução. Em células de mamíferos, as vias d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::720636a57fd9488f76023de97b666dad
Autor:
Marcela Savoldi, Márcia Eliana da Silva Ferreira, Joel Fernandes Lima, Maria Helena S. Goldman, Gustavo H. Goldman, Iran Malavazi, André Mota, José Luiz Capellaro
Publikováno v:
Molecular genetics and genomics : MGG. 279(3)
Nucleotide excision repair (NER) eliminates helix-distorting DNA base lesions. Seven XP-deficient genetic complementation groups (XPA to XPG) have already been identified in mammals, and their corresponding genes have been cloned. Hereditary defects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39434f9fe9ee2866af80ed732f49bcf3
https://pubmed.ncbi.nlm.nih.gov/18060432
https://pubmed.ncbi.nlm.nih.gov/18060432
Autor:
Iran, Malavazi, Joel Fernandes, Lima, Márcia Regina, von Zeska Kress Fagundes, Vladimir P, Efimov, Maria Helena, de Souza Goldman, Gustavo Henrique, Goldman
Publikováno v:
Molecular microbiology. 57(1)
The Mre11-Rad50-Nbs1 protein complex has emerged as a central component in the human cellular DNA damage response, and recent observations suggest that these proteins are at least partially responsible for the linking of DNA damage detection to DNA r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::082b11e650d8154eb288467e5b5f6363
https://pubmed.ncbi.nlm.nih.gov/15948962
https://pubmed.ncbi.nlm.nih.gov/15948962
Autor:
Marcia R V Z Kress, Fagundes, Joel Fernandes, Lima, Marcela, Savoldi, Iran, Malavazi, Roy E, Larson, Maria H S, Goldman, Gustavo H, Goldman
Publikováno v:
Genetics. 167(4)
The DNA damage response is a protective mechanism that ensures the maintenance of genomic integrity. We have used Aspergillus nidulans as a model system to characterize the DNA damage response caused by the antitopoisomerase I drug, camptothecin. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::456a4b694f5428f8bed0f0529361a322
https://pubmed.ncbi.nlm.nih.gov/15342504
https://pubmed.ncbi.nlm.nih.gov/15342504