Výsledky vyhledávání - "Joel F. Moake"

Measurement of von Willebrand factor cleaving protease (ADAMTS-13): results of an international collaborative study involving 11 methods testing the same set of coded plasmas

Autor: J. P. Girma, Armando Tripodi, M. E. Rick, Ulrich Budde, Kenneth D. Friedman, Martina Böhm, Veena Chantarangkul, Peter Turecek, Joel F. Moake, Miriam Galbusera, Jing-fei Dong, P. M. Mannucci, Jan-Dirk Studt

Publikováno v: Journal of thrombosis and haemostasis : JTH. 2(9)

Summary. Background: ADAMTS-13 is a von Willebrand factor (VFW)-cleaving protease. Its congenital or acquired deficiency is associated with thrombotic thrombocytopenic purpura (TTP) and more rarely with the hemolytic uremic syndrome. We report on a s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8abad181a3e0d65e029dfc4ab2806800
https://pubmed.ncbi.nlm.nih.gov/15333037

Zobrazit plný text záznamu

Effects of inflammatory cytokines on the release and cleavage of the endothelial cell-derived ultralarge von Willebrand factor multimers under flow

Autor: Leticia Nolasco, Jing-fei Dong, Joel F. Moake, Aubrey Bernardo, Chalmette Ball

Publikováno v: Blood. 104(1)

ADAMTS13 cleaves ultralarge and hyperreactive von Willebrand factor (ULVWF) freshly released from activated endothelial cells to smaller and less active forms. This process may be affected by the amount of ULVWF released and the processing capacity o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d732d234640829f750e3ca620624f09
https://pubmed.ncbi.nlm.nih.gov/15026315

Zobrazit plný text záznamu

ADAMTS-13 activity in plasma is rapidly measured by a new ELISA method that uses recombinant VWF-A2 domain as substrate

Autor: Joel F. Moake, Aubrey Bernardo, Leticia Nolasco, Jody L. Whitelock, Jing-fei Dong, Miguel A. Cruz

Publikováno v: Journal of thrombosis and haemostasis : JTH. 2(3)

The metalloprotease ADAMTS-13 cleaves von Willebrand factor (VWF) at the Y842/M843 peptide bond located in the A2 domain. Measurement of ADAMTS-13 activity is a clinical utility for thrombotic diseases, but the current assays used for diagnostic and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e27d92c0f7b419dc68f93ad0f424e1d5
https://pubmed.ncbi.nlm.nih.gov/15009467

Zobrazit plný text záznamu

N-Acetyl Cysteine Reduces von Willebrand Factor Multimer Size In Vitro and In Vivo

Autor: Leticia Nolasco, Joel F. Moake, Jose A. Lopez, Junmei Chen, Francisca C. Gushiken

Publikováno v: Blood. 108:420-420

von Willebrand factor (VWF) shares a similar domain structure with many polymeric mucins, including the presence of D domains and a C-terminal cysteine knot, which allows these molecules to form polymeric structures that can reach immense sizes. Prec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::880ce66224eb31c0adfc086bd9af361e
https://doi.org/10.1182/blood.v108.11.420.420

Zobrazit plný text záznamu

ADAMTS-13 Deficiency in Children with Septic Shock

Autor: Li Liu, Jing-fei Dong, Hiuwan Choi, Joel F. Moake, Trung C. Nguyen, Angela L. Bergeron, Leticia Nolasco, Anne Liu, Patricia Mapua

Publikováno v: Blood. 104:848-848

Von Willebrand factor (VWF) is synthesized and released from endothelial cells and megakaryocytes/platelets in a form that is ultra-large (UL) in size and hyper-reactive in functions, capable of spontaneously activating and aggregating platelets. Upo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::89e6049d87f63e3bb4d7eab9e70257ad
https://doi.org/10.1182/blood.v104.11.848.848

Zobrazit plný text záznamu

An In-Frame Deletion of Six Amino Acids and a Point Mutation in the Disintegrin Domain of ADAMTS-13 Associates with a Case of Congenital Thrombotic Thromocytopenic Purpura

Autor: Jing-fei Dong, Bernardo Aubrey, Lawrence Rice, Leticia Nolasco, Zhenyin Tao, Joel F. Moake

Publikováno v: Blood. 104:854-854

Thrombotic thrombocytopenic purpura (TTP) is characterized by severe thrombocytopenia, hemolytic anemia, and diffuse and non-focal neurological findings. Microthrombi found in these patients are predominantly composed of platelets and von Willebrand

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::56b0b8370b973c7b5eeed8ee01091cf5
https://doi.org/10.1182/blood.v104.11.854.854

Zobrazit plný text záznamu

Human Platelets Contain and Release an Active ADAMTS-13-Like Metalloprotease

Autor: Li Liu, Changgeng Ruan, Bernardo Aubrey, Joel F. Moake, Huiwan Choi, Jing-fei Dong, Angila Bergeron, Leticia Nolasco

Publikováno v: Blood. 104:3527-3527

The adhesion ligand von Willebrand factor (VWF) is synthesized and stored in vascular endothelial cells and megakaryocytes/platelets. These cells release VWF in response to similar stimulations. However, a longstanding observation stated that, unlike

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::23a406964f525d1117860d4c9047c3df
https://doi.org/10.1182/blood.v104.11.3527.3527

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání