Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Joel Ellis"'
Autor:
Ron Alfa, Timothy Considine, Shafique Virani, Matt Pfeiffer, Anthony Donato, Daniel Dickerson, Diana Shuster, Joel Ellis, Kristen Rushton, Helen Wei, Christopher Gibson
Publikováno v:
Pharmacology Research & Perspectives, Vol 12, Iss 3, Pp n/a-n/a (2024)
Abstract Cerebral cavernous malformation (CCM) has variable clinical symptoms, including potentially fatal hemorrhagic stroke. Treatment options are very limited, presenting a large unmet need. REC‐994 (also known as tempol), identified as a potent
Externí odkaz:
https://doaj.org/article/abbdde22d4974af7866afbac4ddf80e1
Autor:
Jenny Rudnick, Kiran Nadella, Chase Neumann, Shane Rowley, Ethan Gardner, Shadi Swaidani, Aimee Iberg, Lu Chen, Daria Beshnova, Aurora Blucher, Rebecca Sarto Basso, Malini Rajan, Kevin Fales, Ashraf Saeed, Christopher Bailey, Weston Judd, Chrissy Egbert, Joel Ellis, John Ansede, Pouya Hadipour, Kevin Jessing, Janet Paulsen, Paul Rearden, Vamshi Manda, Sashi Kasimsetty, Michael Hancock, Harish Shankaran, Bryan Ellis, Meenakshy Iyer, Carl Brooks, Ashish Bhandari, Chris Gibson, Irit Rappley, Laura Schaevitz, Imran Haque, Hayley Donnella, Michael Cuccarese, Marie Evangelista
Publikováno v:
Cancer Research. 83:LB071-LB071
The emergence of technological innovations has created the opportunity to envision new approaches to discover therapeutics at scale. We combined advances in high content microscopy with arrayed CRISPR genome editing techniques and machine learning (M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0e323c8afddcc42235da7ba5f49cab0
https://doi.org/10.1158/1538-7445.am2023-lb071
https://doi.org/10.1158/1538-7445.am2023-lb071
Autor:
Albiruni Ryan Abdul Razak, Stephanie Baker, Herbert H. Loong, Sharon Friedlander, Joel Ellis, Mrinal M. Gounder, William D. Tap, Robert O. Carlson, Joseph P. Erinjeri, Alona Zer, Michael Kauffman, Mercedes M. Condy, Mark A. Dickson, Sharon Shacham, Gary K. Schwartz, Francis H. Jasmine, Samer Salah, Tami Rashal, Lanier R. Tanner, Sandra P. D'Angelo, Kjirsten Nyquist-Schultz, Abha A. Gupta, Thaddeus J. Unger, Mary Louise Keohan, Jean-Richard Saint-Martin
Publikováno v:
Journal of Clinical Oncology. 34:3166-3174
Purpose We evaluated the pharmacokinetics (PKs), pharmacodynamics, safety, and efficacy of selinexor, an oral selective inhibitor of nuclear export compound, in patients with advanced soft tissue or bone sarcoma with progressive disease. Patients and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78d10dae3ea1fa1f76b1fecc4dcf97bd
https://doi.org/10.1200/jco.2016.67.6346
https://doi.org/10.1200/jco.2016.67.6346
Autor:
Megan E. Brown, Christian Argueta, Erkan Baloglu, Hua Chang, Elizabeth M. Schuh, Trinayan Kashyap, Sharon Shacham, Cheryl London, Emma E. Warry, William Senapedis, Joel Ellis
Publikováno v:
Cancer Research. 77:LB-308
Nicotinamide adenine dinucleotide (NAD), an essential metabolite and cofactor of several biological processes (e.g. genomic stability), undergoes significant alterations during malignant transformation. In cancer cells, the high metabolic demands of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81c02a4240511698918e1a05be8c1c65
https://doi.org/10.1158/1538-7445.am2017-lb-308
https://doi.org/10.1158/1538-7445.am2017-lb-308
Autor:
Joel Ellis
Publikováno v:
Otolaryngology–Head and Neck Surgery. 151
The speakers’ intention is to explore the medical climate today as it pertains to practicing medicine as a private otolaryngologist: specifically, the challenges a provider faces today and potentially downstream. During turbulent times, medical pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc654b73b1cd058e893d17b6bc5cb4c1
https://doi.org/10.1177/0194599814541629
https://doi.org/10.1177/0194599814541629
Autor:
Joel Ellis, Craig C. Hofmeister, Dan T. Vogl, William Senapedis, Rachid Baz, Sharon Friedlander, Christine Chen, Chaim Shustik, R. Frank Cornell, Daniel C. Sullivan, Joel G. Turner, Sharon Shacham, Cassandra Choe-Juliak, Erkan Baloglu, Michael Kauffman, Christopher L. Cubitt, Joshua R. Richter, Adriana C Rossi
Publikováno v:
Blood. 128:4509-4509
Introduction - Inhibition of Exportin 1 (XPO1) is a novel treatment approach for multiple myeloma (MM). XPO1 mediates the nuclear export of cell-cycle regulators and tumor suppressor proteins leading to their functional inactivation. In addition, XPO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba7d12b259fe2e1c2bbc06673f0331ff
https://doi.org/10.1182/blood.v128.22.4509.4509
https://doi.org/10.1182/blood.v128.22.4509.4509
Autor:
Greg Wright, Patrick Y. Wen, Morten Mau-Sørensen, Aleksander Chudnovsky, Sharon Friedlander, Andrew B. Lassman, Andrew L. Kung, Joel Ellis, Bert van Eijk, Sharon Shacham, Michael Kauffman, Scott R. Plotkin, Ulrik Lassen, Jean-Richard Saint-Martin
Publikováno v:
Journal of Clinical Oncology. 34:2077-2077
2044 Background: Patients (pts) with recurrent GBM have few treatment options and a poor prognosis. Selinexor is an oral inhibitor of XPO1 mediated nuclear export resulting in nuclear retention of ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::043a83c9a9cc47dc3af88a81ab2da1f2
https://doi.org/10.1200/jco.2016.34.15_suppl.2077
https://doi.org/10.1200/jco.2016.34.15_suppl.2077
Autor:
Alla Berezovskaya, Erkan Baloglu, Sharon Shacham, William Senapedis, Dilara McCauley, Julia Etchin, Jean C.Y. Wang, Weihsu Claire Chen, A. Thomas Look, Daniel J. DeAngelo, Michael Kauffman, Ilene Galinsky, Richard Stone, Joel Ellis, Yosef Landesman, Amy Saur Conway
Publikováno v:
Blood. 126:326-326
Currently available combination chemotherapy for AML induces complete remission in about 75% of younger and 45% of older patients, but often fails to induce long-term disease-free survival and is toxic to normal hematopoietic cells. The frequent dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16bd75bd9f619f80b40450647e821172
https://doi.org/10.1182/blood.v126.23.326.326
https://doi.org/10.1182/blood.v126.23.326.326
Autor:
Frank Becker, Marsha Crochiere, Yosef Landesman, Margaret S. Lee, Stefan Hannus, Joel Ellis, Kerrin Hansen
Publikováno v:
Blood. 126:2487-2487
Introduction: Selinexor, a Selective Inhibitor of Nuclear Export (SINE) compound, is an anti-cancer drug that is currently being evaluated in Phase I and II clinical trials for the treatment of solid and hematological malignancies (clinicaltrials.gov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b270e66a9d247e566b59f0f6ab30e9c9
https://doi.org/10.1182/blood.v126.23.2487.2487
https://doi.org/10.1182/blood.v126.23.2487.2487
Autor:
Tami Rashal, Sharon Shacham, Boris Klebanov, Yosef Landesman, Hagop Youssoufian, Jeffrey E. Rubnitz, Raul C. Ribeiro, Ronda Kaufman, Joel Ellis
Publikováno v:
Blood. 126:1345-1345
Background and Purpose: Although novel approaches to the treatment of acute myeloid leukemia (AML) are urgently needed, the heterogeneity of AML and the paucity of known actionable targets indicate that there is an important need for broadly active t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88eed5cdcc23bb5dee63654b706f61aa
https://doi.org/10.1182/blood.v126.23.1345.1345
https://doi.org/10.1182/blood.v126.23.1345.1345