Zobrazeno 1 - 10
of 181
pro vyhledávání: '"Joel E. Lavine"'
Publikováno v:
Metabolites, Vol 13, Iss 8, p 929 (2023)
Non-alcoholic fatty liver disease is a multifaceted disease that progresses through multiple phases; it involves metabolic as well as structural changes. These alterations can be measured directly or indirectly through blood, non-invasive imaging, an
Externí odkaz:
https://doaj.org/article/b639482599344c5cae50d7402f9b2b00
Autor:
Erin E. Elbel, Joel E. Lavine, Michael Downes, Mark Van Natta, Ruth Yu, Jeffrey B. Schwimmer, Cynthia Behling, Elizabeth M. Brunt, James Tonascia, Ronald Evans
Publikováno v:
Hepatology Communications, Vol 2, Iss 10, Pp 1213-1226 (2018)
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in children and adults. This study examined the relationship between hepatic nuclear receptor (NR) expression and histologic features of NAFLD. Drugs targeting
Externí odkaz:
https://doaj.org/article/20fc19426e1640138580ec86b1c18716
Autor:
Idil Arsik, Jennifer K. Frediani, Damon Frezza, Wen Chen, Turgay Ayer, Pinar Keskinocak, Ran Jin, Juna V. Konomi, Sarah E. Barlow, Stavra A. Xanthakos, Joel E. Lavine, Miriam B. Vos
Publikováno v:
Children, Vol 5, Iss 6, p 64 (2018)
Background: Validated noninvasive biomarkers to assess treatment response in pediatric nonalcoholic fatty liver disease (NAFLD) are lacking. We aimed to validate alanine aminotransferase (ALT), a monitoring biomarker for change in liver histology. Me
Externí odkaz:
https://doaj.org/article/7a31ae8b47844545be5d6155076dfee7
Autor:
Elizabeth A. Berg, Zixing Huang, Youya Wang, Jennifer Woo Baidal, Ilene Fennoy, Joel E. Lavine, Jeffrey Zitsman, Wei Shen
Publikováno v:
Journal of pediatric gastroenterology and nutrition. 75(6)
Metabolic and bariatric surgery is the most effective weight loss treatment for severe obesity. The number of adolescents undergoing sleeve gastrectomy is increasing. We investigated changes in body composition in adolescents undergoing sleeve gastre
Autor:
Arun J. Sanyal, Stephen A. Williams, Joel E. Lavine, Brent A. Neuschwander-Tetri, Leigh Alexander, Rachel Ostroff, Hannah Biegel, Kris V. Kowdley, Naga Chalasani, Srinivasan Dasarathy, Anna Mae Diehl, Rohit Loomba, Bilal Hameed, Cynthia Behling, David E. Kleiner, Saul J. Karpen, Jessica Williams, Yi Jia, Katherine P. Yates, James Tonascia
Publikováno v:
Journal of hepatology, vol 78, iss 4
J Hepatol
J Hepatol
There is an unmet need for development of non-invasive tests for the diagnostic assessment and monitoring of nonalcoholic fatty liver disease (NAFLD).Using modified-aptamer proteomics, we assayed 5220 proteins in each of 2852 single serum samples fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b98d930021ee18e344ed6b8fc32118b5
https://escholarship.org/uc/item/0d9809np
https://escholarship.org/uc/item/0d9809np
Autor:
Philip J. Rosenthal, Jean P. Molleston, Cynthia Behling, Tamir Miloh, Kimberly P. Newton, Mark Fishbein, Laura A. Wilson, Miriam B. Vos, Jeffrey B. Schwimmer, Ajay Jain, Joel E. Lavine, Karen F. Murray
Publikováno v:
Hepatology
BACKGROUND AND AIMS Predictive, noninvasive tools are needed to monitor key features of nonalcoholic fatty liver disease (NAFLD) in children that relate to improvement in liver histology. The purpose of this study was to evaluate the relationship bet
Autor:
Wei Shen, Michael S. Middleton, Guilherme M. Cunha, Timoteo I. Delgado, Tanya Wolfson, Anthony Gamst, Kathryn J. Fowler, Adina Alazraki, Andrew T. Trout, Michael A. Ohliger, Shetal N. Shah, Mustafa R. Bashir, David E. Kleiner, Rohit Loomba, Brent A. Neuschwander-Tetri, Arun J. Sanyal, Jane Zhou, Claude B. Sirlin, Joel E. Lavine
Publikováno v:
Journal of hepatology.
Non-alcoholic steatohepatitis (NASH) is prevalent in adults with obesity and can progress to cirrhosis. In a secondary analysis of prospectively acquired data from the multicenter, randomized, placebo-controlled FLINT trial, we investigated the relat
Autor:
Miriam B, Vos, Mark L, Van Natta, Niviann M, Blondet, Srinivasan, Dasarathy, Mark, Fishbein, Paula, Hertel, Ajay K, Jain, Saul J, Karpen, Joel E, Lavine, Saeed, Mohammad, Laura A, Miriel, Jean P, Molleston, Marialena, Mouzaki, Arun, Sanyal, Emily P, Sharkey, Jeffrey B, Schwimmer, James, Tonascia, Laura A, Wilson, Stavra A, Xanthakos
Publikováno v:
Hepatology (Baltimore, Md.). 76(2)
To date, no pharmacotherapy exists for pediatric NAFLD. Losartan, an angiotensin II receptor blocker, has been proposed as a treatment due to its antifibrotic effects.The Nonalcoholic Steatohepatitis Clinical Research Network conducted a multicenter,
Hepatocyte TLR4 triggers inter-hepatocyte Jagged1/Notch signaling to determine NASH-induced fibrosis
Autor:
Michele Carrer, Li Qiang, Xiaobo Wang, Kyeong Jin Kim, Changyu Zhu, Utpal B. Pajvani, Katherine P. Yates, Luca Valenti, Junjie Yu, Thorsten Sadowski, Ira Tabas, Joel E. Lavine, Paola Dongiovanni, Alberto Bartolomé
Publikováno v:
Sci Transl Med
Aberrant hepatocyte Notch activity is critical to the development of nonalcoholic steatohepatitis (NASH)–induced liver fibrosis, but mechanisms underlying Notch reactivation in developed liver are unclear. Here, we identified that increased express
Autor:
Michael S. Middleton, Kathryn J. Fowler, Kris V. Kowdley, James Tonascia, Mark L. Van Natta, Arun J. Sanyal, Cynthia Behling, Adrija Mamidipalli, Wei Shen, Joel E. Lavine, Michael A. Ohliger, Tanya Wolfson, Claude B. Sirlin, Andrew T. Trout, Daniela S. Allende, Rohit Loomba, Jonathan Hooker, Shetal N. Shah, Anthony Gamst, Adina Alazraki, Mustafa R. Bashir, Jeffrey B. Schwimmer
Publikováno v:
Journal of Magnetic Resonance Imaging. 49:1456-1466
Author(s): Bashir, Mustafa R; Wolfson, Tanya; Gamst, Anthony C; Fowler, Kathryn J; Ohliger, Michael; Shah, Shetal N; Alazraki, Adina; Trout, Andrew T; Behling, Cynthia; Allende, Daniela S; Loomba, Rohit; Sanyal, Arun; Schwimmer, Jeffrey; Lavine, Joel