Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Joel E. Beevers"'
Autor:
Joel E. Beevers, Mang Ching Lai, Emma Collins, Heather D.E. Booth, Federico Zambon, Laura Parkkinen, Jane Vowles, Sally A. Cowley, Richard Wade-Martins, Tara M. Caffrey
Publikováno v:
Stem Cell Reports, Vol 9, Iss 2, Pp 587-599 (2017)
Summary: The H1 haplotype of the microtubule-associated protein tau (MAPT) locus is genetically associated with neurodegenerative diseases, including Parkinson's disease (PD), and affects gene expression and splicing. However, the functional impact o
Externí odkaz:
https://doaj.org/article/65db6379c48347cf94044f99e7e5a7ed
Autor:
Richard Wade-Martins, Jane Vowles, Mang Ching Lai, Joel E. Beevers, Laura Parkkinen, Tara M. Caffrey, Sally A. Cowley
Publikováno v:
Alzheimer's & Dementia. 13
Autor:
Paul Davies, Matthew J. Farrer, Eugenia Trushina, Liang Zhang, Bahareh Behrouz, Heather L. Melrose, Sarah Lincoln, Pamela J. McLean, T.A. Christenson, Andreas S. Schroeder, Mei Yue, John D. Fryer, Kelly M. Hinkle, Erin E. Bowles, Joel E. Beevers, Fabienne C. Fiesel, Aishe Kurti, Dennis W. Dickson, Austen J. Milnerwood, Wolfdieter Springer
Publikováno v:
Neurobiology of Disease, Vol 78, Iss, Pp 172-195 (2015)
Mutations in the LRRK2 gene represent the most common genetic cause of late onset Parkinson's disease. The physiological and pathological roles of LRRK2 are yet to be fully determined but evidence points towards LRRK2 mutations causing a gain in kina
Publikováno v:
Biochemical Society transactions. 41(6)
iPSCs (induced pluripotent stem cells) are the newest tool used to model PD (Parkinson's disease). Fibroblasts from patients carrying pathogenic mutations that lead to PD have been reprogrammed into iPSCs, which can subsequently be differentiated int
Autor:
Justus C. Dachsel, Wen Lang Lin, Beate Winner, Matthew J. Farrer, Kenya Nishioka, Bahareh Behrouz, Sarah Lincoln, Joel E. Beevers, Brittany N. Dugger, Iryna Prots, Kelly M. Hinkle, Mei Yue, Erin E. Bowles, Dennis W. Dickson, Heather L. Melrose, Caroline Kent, Christopher Janus
Publikováno v:
Molecular Neurodegeneration
Hinkle, KM; Yue, M; Behrouz, B; Dächsel, JC; Lincoln, SJ; Bowles, EE; et al.(2012). LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors. Molecular Neurodegeneration, 7(1). doi: 10.1186/1750-1326-7-25. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/4974v1qs
Molecular neurodegeneration, vol 7, iss 1
Molecular Neurodegeneration, Vol 7, Iss 1, p 25 (2012)
Hinkle, KM; Yue, M; Behrouz, B; Dächsel, JC; Lincoln, SJ; Bowles, EE; et al.(2012). LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors. Molecular Neurodegeneration, 7(1). doi: 10.1186/1750-1326-7-25. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/4974v1qs
Molecular neurodegeneration, vol 7, iss 1
Molecular Neurodegeneration, Vol 7, Iss 1, p 25 (2012)
Mutations in the LRRK2 gene are the most common cause of genetic Parkinson’s disease. Although the mechanisms behind the pathogenic effects of LRRK2 mutations are still not clear, data emerging from in vitro and in vivo models suggests roles in reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6db6212b8688d146842ba88c0c531313
Autor:
Heather L. Melrose, Justus C. Dachsel, Matthew J. Farrer, Bahareh Behrouz, Mei Yue, Joel E. Beevers
Publikováno v:
Parkinsonism and related disorders. 16(10)
Objective To assess the contribution of wild-type, mutant and loss of leucine-rich repeat kinase-2 (LRRK2; Lrrk2) on dendritic neuronal arborization. Background LRRK2 mutations are recognized as the major genetic determinant of susceptibility to Park
Autor:
L. Witten, Joel E. Beevers, Gerard D. Schellenberg, John-Paul Taylor, G. Tyndall, Heather L. Melrose, Justus C. Dachsel, Kelly M. Hinkle, Bahareh Behrouz, Caroline Kent, Y. Q. Liang, Christopher Janus, V. A. Serna, Monica Castanedes-Casey, Dennis W. Dickson, Matthew J. Farrer, Mei Yue, Xin Yu, Elena Korvatska, Adam Braithwaite, Sarah Lincoln, Brittany N. Dugger, S. Ogholikhan, David I. Bass, Mona Boules, N. Yu, A. Gaukhman
Publikováno v:
Neurobiology of Disease, Vol 40, Iss 3, Pp 503-517 (2010)
Mutations in the Leucine Rich Repeat Kinase 2 (LRRK2) gene, first described in 2004 have now emerged as the most important genetic finding in both autosomal dominant and sporadic Parkinson’s Disease (PD). While a formidable research effort has ensu