Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Joel Desharnais"'
Autor:
Jacob M. Vasquez, Billyana Tsvetanova, Han-Mei Chen, Quyen Bui, Amber N. Murray, Gina L. Costa, Jerry Lu, Katya J. Reshatoff, Joel Desharnais
Publikováno v:
Cancer Research. 80:3110-3110
Liquid biopsy continues to gain traction as a minimally invasive method to monitor biomarkers associated with malignancy and metastasis such as cell-free DNA (cfDNA). However, cell-free DNAs are present in low quantities and are prone to rapid degrad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37dafb40956e7ca6df39c1be3e09fe82
https://doi.org/10.1158/1538-7445.am2020-3110
https://doi.org/10.1158/1538-7445.am2020-3110
Autor:
Jacob M. Vasquez, Joel Desharnais
Publikováno v:
Cancer Research. 80:2854-2854
Expanding the number of -omic (genomic, proteomic, etc.) analyte classes, a single blood draw will serve to increase the scientific value of that sample by affording additional multi-variant analyses. The detection and monitoring of many chronic dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fcee3d8a397d21da4b8e44be121a53c5
https://doi.org/10.1158/1538-7445.am2020-2854
https://doi.org/10.1158/1538-7445.am2020-2854
Autor:
Deborah Luxenberg, J. Christian Baber, Eric Sousa, Xiaotian Zhong, Joel Desharnais, Wood Lauren Diane, Elizabeth Kieras, Aaron M. D’Antona, Tao He, William S. Somers, Jill F. Wright, Mark Stahl, Ronald Kriz, Laura Lin, Lori Fitz
Publikováno v:
Journal of Biological Chemistry. 288:1409-1419
Protein biosynthesis and extracellular secretion are essential biological processes for therapeutic protein production in mammalian cells, which offer the capacity for correct folding and proper post-translational modifications. In this study, we hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3dbb774a021556be664e739e9b9a474
https://doi.org/10.1074/jbc.m112.417717
https://doi.org/10.1074/jbc.m112.417717
Autor:
Gary Woodnutt, Shenping Liu, Wei Li, Jane M. Withka, Xidong Feng, Boris A. Chrunyk, Wood Lauren Diane, Xiayang Qiu, Suman Shanker, Mary Ellen Banker, Parag Sahasrabudhe, Abhijit Bhat, Ping Jin, Curt Bradshaw, Bryan Oates, Rodney W. Lappe, Xi Song, David Tumelty, Matt Griffor, Gang Chen, Judith Jimenez, Atli Thorarensen, Joel Desharnais
Publikováno v:
Scientific Reports
IL-17A is a pro-inflammatory cytokine that has been implicated in autoimmune and inflammatory diseases. Monoclonal antibodies inhibiting IL-17A signaling have demonstrated remarkable efficacy, but an oral therapy is still lacking. A high affinity IL-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9796141dae1e283b99185a98fb649d86
https://doi.org/10.1038/srep26071
https://doi.org/10.1038/srep26071
Autor:
Joselyn Del Rosario, Michelle Parish, Bin Liu, Jie Huang, Ping Jin, Dingguo Liu, Marla J. Matin, Gary Woodnutt, Bryan Oates, Jing-Yu Lai, Nancy Levin, Rodney W. Lappe, Curt W. Bradshaw, Richard A. Lerner, Crystal Hagen, Abhijit Bhat, Robert E. Murphy, Zemeda W Ainekulu, Michael J. Shields, Venkata Doppalapudi, Lingna Li, Joel Desharnais
Publikováno v:
Proceedings of the National Academy of Sciences. 107:22611-22616
Bispecific antibodies (BsAbs) are regarded as promising therapeutic agents due to their ability to simultaneously bind two different antigens. Several bispecific modalities have been developed, but their utility is limited due to problems with stabil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3aab9d8b9d6a1442038b30b585337d7
https://doi.org/10.1073/pnas.1016478108
https://doi.org/10.1073/pnas.1016478108
Autor:
Angelo J. Castellino, Michael James Newman, Chengzao Sun, Zijian Guo, David L. Nelson, Trisha Eustaquio, Simon Eric Aspland, Carlo Ballatore, Qing Li, Philip Goelet, Rosario Silvestre Castillo, Joel Desharnais
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:5194-5198
In the present work, we explore the possibility of introducing selectivity to existing chemotherapeutics via the design of non-pro-drug, bi-functional molecules comprising a microtubule-binding agent and a substrate for a disease-associated kinase. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::627b7c2e9915c550d219d50194a32755
https://doi.org/10.1016/j.bmcl.2006.07.003
https://doi.org/10.1016/j.bmcl.2006.07.003
Autor:
Carlo Ballatore, Simon Eric Aspland, Chengzao Sun, Angelo J. Castellino, Amos B. Smith, Joel Desharnais, Trisha Eustaquio, Rosario Silvestre Castillo
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:2477-2480
A general protocol for the synthesis of paclitaxel C-10 carbamates is described. The method entails MeI-mediated activation of 2′- O -TBS-7- O -TES-10- O -deacetyl-paclitaxel-10- O -carbonylimidazole prior to reaction with amines. This method is ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fec226dd8bfff9f4be5d63a44c5de45e
https://doi.org/10.1016/j.bmcl.2005.03.072
https://doi.org/10.1016/j.bmcl.2005.03.072
Autor:
Justin Baboval, Inkyu Hwang, Dale L. Boger, Joel Desharnais, Ian A. Wilson, Stephen J. Benkovic, Yan Zhang, Ali Tavassoli
Publikováno v:
Bioorganic & Medicinal Chemistry. 11:4511-4521
The synthesis and evaluation of analogues and key derivatives of 10-CF 3 CO-DDACTHF as inhibitors of glycinamide ribonucleotide transformylase (GAR Tfase) and aminoimidazole carboxamide transformylase (AICAR Tfase) are reported. Polyglutamate analogu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b9fed467b4cf7b4ab05df1985b94513
https://doi.org/10.1016/s0968-0896(03)00458-9
https://doi.org/10.1016/s0968-0896(03)00458-9
Autor:
Yan Zhang, Ali Tavassoli, Thomas H. Marsilje, Michael P. Hedrick, Ian A. Wilson, Stephen J. Benkovic, Joel Desharnais, Dale L. Boger
Publikováno v:
Bioorganic & Medicinal Chemistry. 11:4487-4501
A series of simplified alpha-keto heterocycle, trifluoromethyl ketone, and formyl substituted folate analogues lacking the benzoylglutamate subunit were prepared and examined as potential inhibitors of glycinamide ribonucleotide transformylase (GAR T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1e631196a9af7128711f15b006dbacf
https://doi.org/10.1016/s0968-0896(03)00456-5
https://doi.org/10.1016/s0968-0896(03)00456-5
Publikováno v:
Angewandte Chemie International Edition. 42:4138-4176
The high-throughput synthesis and screening of compound libraries hold tremendous promise for drug discovery and powerful methods for both solid-phase and solution-phase library preparation have been introduced. The question of which approach (soluti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a2db3ffacb5f779ab36243c728ed72d
https://doi.org/10.1002/anie.200300574
https://doi.org/10.1002/anie.200300574