Zobrazeno 1 - 10
of 168
pro vyhledávání: '"Joel D. Richter"'
Publikováno v:
Molecular Autism, Vol 11, Iss 1, Pp 1-18 (2020)
Abstract Background Mutations in TSC2 are the most common cause of tuberous sclerosis (TSC), a disorder with a high incidence of autism and intellectual disability. TSC2 regulates mRNA translation required for group 1 metabotropic glutamate receptor-
Externí odkaz:
https://doaj.org/article/fe0a21c738634175b57fa343cd984d09
Autor:
Sneha Shah, Joel D. Richter
Publikováno v:
Frontiers in Psychiatry, Vol 12 (2021)
Fragile X Syndrome is a neuro-developmental disorder caused by the silencing of the FMR1 gene, resulting in the loss of its protein product, FMRP. FMRP binds mRNA and represses general translation in the brain. Transcriptome analysis of the Fmr1-defi
Externí odkaz:
https://doaj.org/article/e9fb5bce14f540c48a393ea8e3381764
Publikováno v:
Cell Reports, Vol 20, Iss 3, Pp 683-696 (2017)
Translation of mRNAs in dendrites mediates synaptic plasticity, the probable cellular basis of learning and memory. Coordination of translational inhibitory and stimulatory mechanisms, as well as dendritic transport of mRNA, is necessary to ensure pr
Externí odkaz:
https://doaj.org/article/efd04666775544589a18c005d5e90d7a
Publikováno v:
Cell Reports, Vol 2, Iss 6, Pp 1537-1545 (2012)
MicroRNAs (miRNAs) are small, noncoding RNAs that inhibit translation and promote mRNA decay. The levels of mature miRNAs are the result of different rates of transcription, processing, and turnover. The noncanonical polymerase Gld2 has been implicat
Externí odkaz:
https://doaj.org/article/251e0636e4a04a03945d34f07eef3dbc
Publikováno v:
PLoS Biology, Vol 21, Iss 12, p e3002417 (2023)
Fragile X syndrome (FXS) is a neurodevelopmental disorder that is often modeled in Fmr1 knockout mice where the RNA-binding protein FMRP is absent. Here, we show that in Fmr1-deficient mice, RNA mis-splicing occurs in several brain regions and periph
Externí odkaz:
https://doaj.org/article/d559a06034654e76a7ae189825f49e1a
Publikováno v:
Molecular Psychiatry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7db58a9a293fb5f51ddbd7ac11c9825
https://doi.org/10.1038/s41380-023-02088-x
https://doi.org/10.1038/s41380-023-02088-x
Autor:
Maria P. Ivshina, Heleen M. van 't Spijker, Suna Jung, Sithara Raju Ponny, Dorothy P. Schafer, Joel D. Richter
Publikováno v:
Glia. 70:1850-1863
Microglia are myeloid cells of the central nervous system that perform tasks essential for brain development, neural circuit homeostasis, and neural disease. Microglia react to inflammatory stimuli by upregulating inflammatory signaling through sever
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfb5b211d57037d1e4f8a407d64f68a3
https://doi.org/10.1002/glia.24222
https://doi.org/10.1002/glia.24222
Autor:
Jihae Shin, Ki Young Paek, Lies Chikhaoui, Suna Jung, SitharaRaju Ponny, Yutaka Suzuki, Kiran Padmanabhan, Joel D. Richter
Publikováno v:
RNA. 28:756-765
Poly(A) tail length is regulated in both the nucleus and cytoplasm. One factor that controls polyadenylation in the cytoplasm is CPEB1, an RNA binding protein that associates with specific mRNA 3′UTR sequences to tether enzymes that add and remove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc8eb49ec9b680d304db9af8262c413d
https://doi.org/10.1261/rna.079050.121
https://doi.org/10.1261/rna.079050.121
Autor:
Olga Katsara, Emily E. Stackpole, Heleen M van 't Spijker, Fen-Biao Gao, Botao Liu, Joel D. Richter, Sandra Almeida, Robert J. Schneider, Kuang Shen
Publikováno v:
RNA. 28:123-138
GGGGCC (G4C2) repeat expansion in the first intron of C9ORF72 causes amyotrophic lateral sclerosis and frontotemporal dementia. Repeat-containing RNA is translated into dipeptide repeat (DPR) proteins, some of which are neurotoxic. Using dynamic ribo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3558885bf64cda9fbe0c9e6b07f9197
https://doi.org/10.1261/rna.078963.121
https://doi.org/10.1261/rna.078963.121
The neurodevelopmental disorder Fragile X Syndrome (FXS) is often modeled in Fmr1 knockout mice, which results in the loss of the RNA binding protein FMRP. In the brain, FMRP stalls ribosomes on specific mRNAs including Setd2, whose encoded protein c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e47a218f486c8edc946302a8d8d7616
https://doi.org/10.1101/2022.08.02.502495
https://doi.org/10.1101/2022.08.02.502495
