Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Joel D. A. Tyndall"'
Autor:
Kiel Hards, Chen-Yi Cheung, Natalie Waller, Cara Adolph, Laura Keighley, Zhi Shean Tee, Liam K. Harold, Ayana Menorca, Richard S. Bujaroski, Benjamin J. Buckley, Joel D. A. Tyndall, Matthew B. McNeil, Kyu Y. Rhee, Helen K. Opel-Reading, Kurt Krause, Laura Preiss, Julian D. Langer, Thomas Meier, Erik J. Hasenoehrl, Michael Berney, Michael J. Kelso, Gregory M. Cook
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
Derivatives of the FDA-approved drug, amiloride, can eliminate drug-resistant Mycobacterium tuberculosis in vitro by interfering with bacterial energy conservation.
Externí odkaz:
https://doaj.org/article/dae3bf53428948ca8c7fbb2eb80c8d45
Autor:
Lorissa McDougall, Jui Thiang Brian Kueh, Jake Ward, Joel D. A. Tyndall, Adele G. Woolley, Sunali Mehta, Cherie Stayner, David S. Larsen, Michael R. Eccles
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Colorectal cancer is primarily a disease of the developed world. The incidence rate has continued to increase over time, reflecting both demographic and lifestyle changes, which have resulted in genomic and epigenomic modifications. Many of the epige
Externí odkaz:
https://doaj.org/article/7c0470994dd64154b474f501a830dc33
Autor:
Yongjian Wen, Wenhao Cai, Jingyu Yang, Xianghui Fu, Lohitha Putha, Qing Xia, John A. Windsor, Anthony R. Phillips, Joel D. A. Tyndall, Dan Du, Tingting Liu, Wei Huang
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine implicated in the pathogenesis of inflammation and cancer. It is produced by various cells and circulating MIF has been identified as a biomarker for a range of diseases. Extracel
Externí odkaz:
https://doaj.org/article/fccf828dca294a1fae4c27d6a57991b2
Publikováno v:
Pharmaceutics, Vol 14, Iss 2, p 348 (2022)
Nanoparticle drug delivery systems have emerged as a promising strategy for overcoming limitations of antimicrobial drugs such as stability, bioavailability, and insufficient exposure to the hard-to-reach bacterial drug targets. Although size is a vi
Externí odkaz:
https://doaj.org/article/5e76a73fb76b4977bd07aad7aba67289
Publikováno v:
Journal of Fungi, Vol 8, Iss 1, p 69 (2022)
The fungal cytochrome P450 lanosterol 14α-demethylase (CYP51) is required for the biosynthesis of fungal-specific ergosterol and is the target of azole antifungal drugs. Despite proven success as a clinical target for azole antifungals, there is an
Externí odkaz:
https://doaj.org/article/8861ba2508d547b8953aff0aa4a211c1
Autor:
Danyon O. Graham, Rajni K. Wilson, Yasmeen N. Ruma, Mikhail V. Keniya, Joel D. A. Tyndall, Brian C. Monk
Publikováno v:
Journal of Fungi, Vol 7, Iss 11, p 897 (2021)
Target-based azole resistance in Candida albicans involves overexpression of the ERG11 gene encoding lanosterol 14α-demethylase (LDM), and/or the presence of single or multiple mutations in this enzyme. Overexpression of Candida albicans LDM (CaLDM)
Externí odkaz:
https://doaj.org/article/2fb14a794e4d4733aafc6a6df72d6c0b
Publikováno v:
Pharmaceuticals, Vol 14, Iss 2, p 103 (2021)
Androgen receptor (AR)-null prostate tumors have been observed in 11–24% of patients. Histone deacetylases (HDACs) are overexpressed in prostate tumors. Therefore, HDAC inhibitors (Jazz90 and Jazz167) were examined in AR-null prostate cancer cell l
Externí odkaz:
https://doaj.org/article/551f0a6073ae4aec8deed1164883d3a7
Autor:
James D. Crowley, Christopher M. Fitchett, Lyall R. Hanton, Brian C. Monk, Alia Sagatova, Joel D. A. Tyndall, Madhu Shankar, James E. M. Lewis, Sreedhar K. Vellas
Publikováno v:
Molecules, Vol 18, Iss 6, Pp 6383-6407 (2013)
A series of metallosupramolecular [Fe2L3](BF4)4 “click” cylinders have been synthesized in excellent yields (90%–95%) from [Fe(H2O)6](BF4)2 and bis(bidentate) pyridyl-1,2,3-triazole ligands. All complexes were characterized by elemental analysi
Externí odkaz:
https://doaj.org/article/41a265ce929c4888a94475e580927c95
Publikováno v:
RSC Med Chem
X-ray crystallography and cryogenic electronic microscopy have provided significant advancement in the knowledge of GPCR structure and have allowed the rational design of GPCR ligands. The class A GPCRs cannabinoid receptor type 1 and type 2 are impl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80050f3a39e4b4196cb62e56bc9284e6
https://doi.org/10.1039/d2md00006g
https://doi.org/10.1039/d2md00006g
Publikováno v:
ChemPhotoChem. 7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a815b85221e5549f32d83ff2f480e934
https://doi.org/10.1002/cptc.202200291
https://doi.org/10.1002/cptc.202200291