Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Joel D Allen"'
Autor:
Rajesh P Ringe, Philippe Colin, Gabriel Ozorowski, Joel D Allen, Anila Yasmeen, Gemma E Seabright, Jeong Hyun Lee, Aleksandar Antanasijevic, Kimmo Rantalainen, Thomas Ketas, John P Moore, Andrew B Ward, Max Crispin, P J Klasse
Publikováno v:
PLoS Pathogens, Vol 19, Iss 10, p e1011601 (2023)
Neutralizing antibodies (NAbs) to multiple epitopes on the HIV-1-envelope glycoprotein (Env) have been isolated from infected persons. The potency of NAbs is measured more often than the size of the persistent fraction of infectivity at maximum neutr
Externí odkaz:
https://doaj.org/article/7568988b535a466f9fbb76d93f1b2ea9
Autor:
Saly Al-Taei, Sian E Faustini, Marisol Perez-Toledo, Sian Jossi, Joel D Allen, Claire Backhouse, Daniel Ebanks, Beena Emmanuel, Mark Garvey, Golaleh McGinnell, Yasunori Watanabe, Max Crispin, David C Wraith, Adam F Cunningham, Mark T Drayson, Alex G Richter, Adrian M Shields, Lynsey A Dunbar, Aduragbemi A Faniyi, Annabel Grinbergs, Joanne O'Neill
Publikováno v:
BMJ Open Respiratory Research, Vol 8, Iss 1 (2021)
Externí odkaz:
https://doaj.org/article/e0200576b9bb42ee8e2962a819f96364
Autor:
Emma T Crooks, Francisco Almanza, Alessio D'Addabbo, Erika Duggan, Jinsong Zhang, Kshitij Wagh, Huihui Mou, Joel D Allen, Alyssa Thomas, Keiko Osawa, Bette T Korber, Yaroslav Tsybovsky, Evan Cale, John Nolan, Max Crispin, Laurent K Verkoczy, James M Binley
Publikováno v:
PLoS Pathogens, Vol 17, Iss 10, p e1009807 (2021)
HIV-1 vaccine immunofocusing strategies may be able to induce broadly-reactive neutralizing antibodies (NAbs). Here, we engineered a panel of diverse, membrane-resident native HIV-1 trimers vulnerable to two broad targets-the V2 apex and fusion pepti
Externí odkaz:
https://doaj.org/article/1fe018ddda00476f8ca88d447d3fcea2
Autor:
Chang-Chun D Lee, Yasunori Watanabe, Nicholas C Wu, Julianna Han, Sonu Kumar, Tossapol Pholcharee, Gemma E Seabright, Joel D Allen, Chih-Wei Lin, Ji-Rong Yang, Ming-Tsan Liu, Chung-Yi Wu, Andrew B Ward, Max Crispin, Ian A Wilson
Publikováno v:
PLoS Pathogens, Vol 17, Iss 3, p e1009407 (2021)
Incessant antigenic evolution enables the persistence and spread of influenza virus in the human population. As the principal target of the immune response, the hemagglutinin (HA) surface antigen on influenza viruses continuously acquires and replace
Externí odkaz:
https://doaj.org/article/33e774135c4b47ed9aea851ca8a7a514
Autor:
Aleksandar Antanasijevic, George Ueda, Philip J M Brouwer, Jeffrey Copps, Deli Huang, Joel D Allen, Christopher A Cottrell, Anila Yasmeen, Leigh M Sewall, Ilja Bontjer, Thomas J Ketas, Hannah L Turner, Zachary T Berndsen, David C Montefiori, Per Johan Klasse, Max Crispin, David Nemazee, John P Moore, Rogier W Sanders, Neil P King, David Baker, Andrew B Ward
Publikováno v:
PLoS Pathogens, Vol 16, Iss 8, p e1008665 (2020)
Two-component, self-assembling nanoparticles represent a versatile platform for multivalent presentation of viral antigens. Computational design of protein nanoparticles with differing sizes and geometries enables combination with antigens of choice
Externí odkaz:
https://doaj.org/article/bef6f6ca42a24283ba89afa6be5d0385
Autor:
Alba Torrents de la Peña, Kimmo Rantalainen, Christopher A Cottrell, Joel D Allen, Marit J van Gils, Jonathan L Torres, Max Crispin, Rogier W Sanders, Andrew B Ward
Publikováno v:
PLoS Pathogens, Vol 15, Iss 7, p e1007920 (2019)
The HIV-1 envelope glycoprotein (Env) trimer is located on the surface of the virus and is the target of broadly neutralizing antibodies (bNAbs). Recombinant native-like soluble Env trimer mimetics, such as SOSIP trimers, have taken a central role in
Externí odkaz:
https://doaj.org/article/657d2b89dfa946ecb5eb39f97b3be3f5
Autor:
Gabriella L. Morley, Stephen Taylor, Sian Jossi, Marisol Perez-Toledo, Sian E. Faustini, Edith Marcial-Juarez, Adrian M. Shields, Margaret Goodall, Joel D. Allen, Yasunori Watanabe, Maddy L. Newby, Max Crispin, Mark T. Drayson, Adam F. Cunningham, Alex G. Richter, Matthew K. O’Shea
Publikováno v:
Emerging Infectious Diseases, Vol 26, Iss 12, Pp 2970-2973 (2020)
Dried blood spot (DBS) samples can be used for the detection of severe acute respiratory syndrome coronavirus 2 spike antibodies. DBS sampling is comparable to matched serum samples with a relative 98.1% sensitivity and 100% specificity. Thus, DBS sa
Externí odkaz:
https://doaj.org/article/365684546bd3483a88bc7cf4c95209a9
Autor:
Alba Torrents de la Peña, Kwinten Sliepen, Lisa Eshun-Wilson, Maddy Newby, Joel D. Allen, Sylvie Koekkoek, Ian Zon, Ana Chumbe, Max Crispin, Janke Schinkel, Gabriel C. Lander, Rogier W. Sanders, Andrew B. Ward
Publikováno v:
Science, 378(6617), 263-269. American Association for the Advancement of Science
Hepatitis C virus (HCV) infection is a leading cause of chronic liver disease, cirrhosis, and hepatocellular carcinoma in humans, and afflicts more than 58 million people worldwide. The HCV envelope E1 and E2 glycoproteins are essential for viral ent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02bf3261588b7d6e8cfb6a8c55b97543
https://doi.org/10.1126/science.abn9884
https://doi.org/10.1126/science.abn9884
Autor:
Raiees Andrabi, Jesper Pallesen, Joel D. Allen, Ge Song, Jinsong Zhang, Natalia de Val, Gavin Gegg, Katelyn Porter, Ching-Yao Su, Matthias Pauthner, Amanda Newman, Hilary Bouton-Verville, Fernando Garces, Ian A. Wilson, Max Crispin, Beatrice H. Hahn, Barton F. Haynes, Laurent Verkoczy, Andrew B. Ward, Dennis R. Burton
Publikováno v:
Cell Reports, Vol 27, Iss 8, Pp 2426-2441.e6 (2019)
Summary: Epitope-targeted HIV vaccine design seeks to focus antibody responses to broadly neutralizing antibody (bnAb) sites by sequential immunization. A chimpanzee simian immunodeficiency virus (SIV) envelope (Env) shares a single bnAb site, the va
Externí odkaz:
https://doaj.org/article/b97d5aec55ed48d4964fabc5c88bcd5d
Autor:
Tom G. Caniels, Max Medina-Ramírez, Jinsong Zhang, Anita Sarkar, Sonu Kumar, Alex LaBranche, Ronald Derking, Joel D. Allen, Jonne L. Snitselaar, Joan Capella-Pujol, Iván del Moral Sánchez, Anila Yasmeen, Marilyn Diaz, Yoann Aldon, Tom P.L. Bijl, Sravani Venkatayogi, Joshua S. Martin Beem, Amanda Newman, Chuancang Jiang, Wen-Hsin Lee, Maarten Pater, Judith A. Burger, Mariëlle J. van Breemen, Steven W. de Taeye, Kimmo Rantalainen, Celia LaBranche, Kevin O. Saunders, David Montefiori, Gabriel Ozorowski, Andrew B. Ward, Max Crispin, John P. Moore, Per Johan Klasse, Barton F. Haynes, Ian A. Wilson, Kevin Wiehe, Laurent Verkoczy, Rogier W. Sanders
Publikováno v:
Cell Reports Medicine, 4(4):101003. Cell Press
Targeting germline (gl-) precursors of broadly neutralizing antibodies (bNAbs) is acknowledged as an important strategy for HIV-1 vaccines. The VRC01-class of bNAbs is attractive because of its distinct genetic signature. However, VRC01-class bNAbs o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0abe01ee8ed5d55e0d1a359126af9aa
https://pure.amc.nl/en/publications/germlinetargeting-hiv1-env-vaccination-induces-vrc01class-antibodies-with-rare-insertions(4a3cf33f-bbcf-4f4c-ad44-92262e9dbc5d).html
https://pure.amc.nl/en/publications/germlinetargeting-hiv1-env-vaccination-induces-vrc01class-antibodies-with-rare-insertions(4a3cf33f-bbcf-4f4c-ad44-92262e9dbc5d).html
