Zobrazeno 1 - 10
of 158
pro vyhledávání: '"Joel D, Ernst"'
Autor:
Weihao Zheng, I-Chang Chang, Jason Limberis, Jonathan M Budzik, Beth Shoshana Zha, Zachary Howard, Lucas Chen, Joel D Ernst
Publikováno v:
PLoS Pathogens, Vol 20, Iss 5, p e1012205 (2024)
Mycobacterium tuberculosis (Mtb) infects lung myeloid cells, but the specific Mtb-permissive cells and host mechanisms supporting Mtb persistence during chronic infection are incompletely characterized. We report that after the development of T cell
Externí odkaz:
https://doaj.org/article/4dce6a47034b4f2db7cf2ce38e6f5d2a
Autor:
Paul Ogongo, Anthony Tran, Florence Marzan, David Gingrich, Melissa Krone, Francesca Aweeka, Cecilia S. Lindestam Arlehamn, Jeffrey N. Martin, Steven G. Deeks, Peter W. Hunt, Joel D. Ernst
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundInterleukin-17–producing CD4 T cells contribute to the control of Mycobacterium tuberculosis (Mtb) infection in humans; whether infection with human immunodeficiency virus (HIV) disproportionately affects distinct Th17-cell subsets that r
Externí odkaz:
https://doaj.org/article/af207d4c66734e13b49fa7ac8b2e1337
Autor:
Michaela Zwyer, Liliana K Rutaihwa, Etthel Windels, Jerry Hella, Fabrizio Menardo, Mohamed Sasamalo, Gregor Sommer, Lena Schmülling, Sonia Borrell, Miriam Reinhard, Anna Dötsch, Hellen Hiza, Christoph Stritt, George Sikalengo, Lukas Fenner, Bouke C De Jong, Midori Kato-Maeda, Levan Jugheli, Joel D Ernst, Stefan Niemann, Leila Jeljeli, Marie Ballif, Matthias Egger, Niaina Rakotosamimanana, Dorothy Yeboah-Manu, Prince Asare, Bijaya Malla, Horng Yunn Dou, Nicolas Zetola, Robert J Wilkinson, Helen Cox, E Jane Carter, Joachim Gnokoro, Marcel Yotebieng, Eduardo Gotuzzo, Alash'le Abimiku, Anchalee Avihingsanon, Zhi Ming Xu, Jacques Fellay, Damien Portevin, Klaus Reither, Tanja Stadler, Sebastien Gagneux, Daniela Brites
Publikováno v:
PLoS Pathogens, Vol 19, Iss 4, p e1010893 (2023)
In settings with high tuberculosis (TB) endemicity, distinct genotypes of the Mycobacterium tuberculosis complex (MTBC) often differ in prevalence. However, the factors leading to these differences remain poorly understood. Here we studied the MTBC p
Externí odkaz:
https://doaj.org/article/ba4d547f4bca4dfbb5d867e96b99308e
Publikováno v:
PLoS ONE, Vol 18, Iss 11, p e0289442 (2023)
Non-polyadenylated RNA includes a large subset of crucial regulators of RNA expression and constitutes a substantial portion of the transcriptome, playing essential roles in gene regulation. For example, enhancer RNAs are long non-coding RNAs that pe
Externí odkaz:
https://doaj.org/article/f56ffaac10e1489b830d881f08480ce0
Publikováno v:
PLoS ONE, Vol 18, Iss 9, p e0288687 (2023)
Targeted amplicon sequencing to identify pathogens, resistance-conferring mutations, and strain types is an important tool in diagnosing and treating infections. However, due to the short read limitations of Illumina sequencing, many applications req
Externí odkaz:
https://doaj.org/article/7f7c3e72b95d4d5bb1ed0e3fb9f902a6
Autor:
B. Shoshana Zha, Ludovic Desvignes, Tawania J. Fergus, Amber Cornelius, Tan-Yun Cheng, D. Branch Moody, Joel D. Ernst
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
ABSTRACT In the initial stage of respiratory infection, Mycobacterium tuberculosis traverses from alveolar macrophages to phenotypically diverse monocyte-derived phagocytes and neutrophils in the lung parenchyma. Here, we compare the in vivo kinetics
Externí odkaz:
https://doaj.org/article/9716fe0702914c99abc5fa7e500838e1
Autor:
Valentina Ceglia, Erin J. Kelley, Annalee S. Boyle, Sandra Zurawski, Heather L. Mead, Caroline E. Harms, Jean-Philippe Blanck, Anne-Laure Flamar, Jung Hwa Kirschman, Paul Ogongo, Joel D. Ernst, Yves Levy, Gerard Zurawski, John A. Altin
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Common approaches for monitoring T cell responses are limited in their multiplexity and sensitivity. In contrast, deep sequencing of the T Cell Receptor (TCR) repertoire provides a global view that is limited only in terms of theoretical sensitivity
Externí odkaz:
https://doaj.org/article/f93445a02b2b471c835e0f59d1527059
Autor:
Juan Rivera-Correa, Isadora Cristina de Siqueira, Sabrina Mota, Mateus Santana do Rosário, Pedro Antônio Pereira de Jesus, Luiz Carlos Junior Alcantara, Joel D Ernst, Ana Rodriguez
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 13, Iss 9, p e0007695 (2019)
Zika virus infection is associated with the development of Guillain-Barré syndrome (GBS), a neurological autoimmune disorder caused by immune recognition of gangliosides and other components at nerve membranes. Using a high-throughput ELISA, we have
Externí odkaz:
https://doaj.org/article/19da0409e4bd4d6cb43c938041597bfc
Publikováno v:
mBio, Vol 10, Iss 2 (2019)
ABSTRACT Secretion of specific proteins contributes to pathogenesis and immune responses in tuberculosis and other bacterial infections, yet the kinetics of protein secretion and fate of secreted proteins in vivo are poorly understood. We generated n
Externí odkaz:
https://doaj.org/article/173c39e1cc6e4be997263edbf09e92f2
Autor:
Andrew J. Sawyer, Ellis Patrick, Jarem Edwards, James S. Wilmott, Timothy Fielder, Qianting Yang, Daniel L. Barber, Joel D. Ernst, Warwick J. Britton, Umaimainthan Palendira, Xinchun Chen, Carl G. Feng
Publikováno v:
Journal of Experimental Medicine. 220
The hallmark of tuberculosis (TB) is the formation of immune cell-enriched aggregates called granulomas. While granulomas are pathologically diverse, their tissue-wide heterogeneity has not been spatially resolved at the single-cell level in human ti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dacbe53ab4fc27480f436e0b6d71721a
https://doi.org/10.1084/jem.20221392
https://doi.org/10.1084/jem.20221392